Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Tan-Yun Cheng"'
Autor:
Claire E. Kitzmiller, Tan-Yun Cheng, Jacques Prandi, Ian L. Sparks, D. Branch Moody, Yasu S. Morita
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100533- (2024)
Mycobacterial plasma membrane, together with the peptidoglycan-arabinogalactan cell wall and waxy outer membrane, creates a robust permeability barrier against xenobiotics. The fact that several antituberculosis drugs target plasma membrane-embedded
Externí odkaz:
https://doaj.org/article/c69e08bf9eef4c7a8b8a10a024369e04
Autor:
Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E. Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P. O’Sullivan, Seónadh O’Leary, Jacob A. Mayfield, Jeffrey Buter, Adriaan J. Minnaard, Sarah M. Fortune, Leon O. Murphy, Daniel S. Ory, Joseph Keane, Sho Yamasaki, Maximiliano G. Gutierrez, Nicole van der Wel, D. Branch Moody
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl
Externí odkaz:
https://doaj.org/article/66ad604010504fdab74173379c2c7ca6
Autor:
B. Shoshana Zha, Ludovic Desvignes, Tawania J. Fergus, Amber Cornelius, Tan-Yun Cheng, D. Branch Moody, Joel D. Ernst
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare the in vivo kinetics
Externí odkaz:
https://doaj.org/article/9716fe0702914c99abc5fa7e500838e1
Autor:
Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derive
Externí odkaz:
https://doaj.org/article/8b688ab776554395acd758b05b541c3e
Autor:
Jumei Zeng, John Platig, Tan-Yun Cheng, Saima Ahmed, Yara Skaf, Lakshmi-Prasad Potluri, Daniel Schwartz, Hanno Steen, D Branch Moody, Robert N Husson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008452 (2020)
The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a titratable conditional depletion system to investigate the functions of these kinases. Depletion
Externí odkaz:
https://doaj.org/article/f6cb6ba14db54df4a334994a81d456e5
Autor:
Joury S van 't Klooster, Tan-Yun Cheng, Hendrik R Sikkema, Aike Jeucken, Branch Moody, Bert Poolman
Publikováno v:
eLife, Vol 9 (2020)
Yeast tolerates a low pH and high solvent concentrations. The permeability of the plasma membrane (PM) for small molecules is low and lateral diffusion of proteins is slow. These findings suggest a high degree of lipid order, which raises the questio
Externí odkaz:
https://doaj.org/article/51119df5db0440f5a4a92bf00b7bc3e5
Autor:
Stephanie Gras, Ildiko Van Rhijn, Adam Shahine, Tan-Yun Cheng, Mugdha Bhati, Li Lynn Tan, Hanim Halim, Kathryn D. Tuttle, Laurent Gapin, Jérôme Le Nours, D. Branch Moody, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-r
Externí odkaz:
https://doaj.org/article/6334ebee5b454f54b0c32fa67fdc1261
Autor:
Amanda J Martinot, Mary Farrow, Lu Bai, Emilie Layre, Tan-Yun Cheng, Jennifer H Tsai, Jahangir Iqbal, John W Annand, Zuri A Sullivan, M Mahmood Hussain, James Sacchettini, D Branch Moody, Jessica C Seeliger, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005351 (2016)
Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to int
Externí odkaz:
https://doaj.org/article/3122182a17664a31b85cc45e21e4b8b4
Autor:
Cressida A Madigan, Amanda Jezek Martinot, Jun-Rong Wei, Ashoka Madduri, Tan-Yun Cheng, David C Young, Emilie Layre, Jeffrey P Murry, Eric J Rubin, D Branch Moody
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004792 (2015)
The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme iron using mycobactin and carboxymycobactin siderophores, synthesized by myco
Externí odkaz:
https://doaj.org/article/e42074d0df95400da6d67ff886ee2b4a
Autor:
Sunhee Hong, Tan-Yun Cheng, Emilie Layre, Lindsay Sweet, David C Young, James E Posey, W Ray Butler, D Branch Moody
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39017 (2012)
Mycolic acid-producing bacteria isolated from the respiratory tract of human and non-human mammals were recently assigned as a distinct genus, Segniliparus, because they diverge from rhodococci and mycobacteria in genetic and chemical features. Using
Externí odkaz:
https://doaj.org/article/04891a8926ed4b07aa2c79c34e8511ec