Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss.

Autor: Tan WJT; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1023, New Zealand. Electronic address: winston.tan@auckland.ac.nz., Song L; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Otolaryngology - Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China; Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China. Electronic address: lei.song@yale.edu.

Publikováno v: Hearing research [Hear Res] 2023 Jul; Vol. 434, pp. 108783. Date of Electronic Publication: 2023 Apr 29.

Outer hair cell function is normal in βV spectrin knockout mice.

Autor: Stankewich MC; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Bai JP; Department of Neurology, Yale School of Medicine, PO Box 208018, New Haven, CT 06519, USA., Stabach PR; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Khan S; Cranbrook Kingswood Upper School, MI, USA., Tan WJT; Department of Surgery, Yale School of Medicine, New Haven, CT, USA., Surguchev A; Department of Surgery, Yale School of Medicine, New Haven, CT, USA., Song L; Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Morrow JS; Department of Pathology, Yale School of Medicine, New Haven, CT, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA., Santos-Sacchi J; Department of Surgery, Yale School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA., Navaratnam DS; Department of Neurology, Yale School of Medicine, PO Box 208018, New Haven, CT 06519, USA; Department of Surgery, Yale School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA. Electronic address: dhasakumar.navaratnam@yale.edu.

Publikováno v: Hearing research [Hear Res] 2022 Sep 15; Vol. 423, pp. 108564. Date of Electronic Publication: 2022 Jul 03.

Single particle cryo-EM structure of the outer hair cell motor protein prestin.

Autor: Butan C; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, USA., Song Q; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, USA., Bai JP; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA., Tan WJT; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, USA., Navaratnam D; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, USA. dhasakumar.navaratnam@yale.edu.; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. dhasakumar.navaratnam@yale.edu.; Neuroscience, Yale University School of Medicine, New Haven, CT, USA. dhasakumar.navaratnam@yale.edu., Santos-Sacchi J; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT, USA. joseph.santos-sacchi@yale.edu.; Neuroscience, Yale University School of Medicine, New Haven, CT, USA. joseph.santos-sacchi@yale.edu.; Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. joseph.santos-sacchi@yale.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Jan 12; Vol. 13 (1), pp. 290. Date of Electronic Publication: 2022 Jan 12.

Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice.

Autor: Nguyen LD; Department of Pharmacology, Yale University, 333 Cedar St, New Haven, CT, USA.; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA.; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Nolte LG; Department of Pharmacology, Yale University, 333 Cedar St, New Haven, CT, USA.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Und Hochschulambulanz Für Neurologie, 10117, Berlin, Germany., Tan WJT; Department of Surgery (Otolaryngology), Yale University, New Haven, CT, USA., Giuvelis D; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, USA., Santos-Sacchi J; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA.; Department of Surgery (Otolaryngology), Yale University, New Haven, CT, USA.; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA.; Department of Neuroscience, Yale University, New Haven, CT, USA., Bilsky E; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, USA.; Department of Biomedical Sciences, Pacific Northwest University of Health Sciences, Yakima, WA, USA., Ehrlich BE; Department of Pharmacology, Yale University, 333 Cedar St, New Haven, CT, USA. barbara.ehrlich@yale.edu.; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA. barbara.ehrlich@yale.edu.; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA. barbara.ehrlich@yale.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 27; Vol. 11 (1), pp. 2372. Date of Electronic Publication: 2021 Jan 27.

Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.

Autor: Tan WJT; 1 Department of Surgery, Section of Otolaryngology, Yale University School of Medicine , New Haven, Connecticut., Song L; 2 Department of Otolaryngology-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .; 3 Ear Institute, Shanghai Jiao Tong University School of Medicine , Shanghai, China .; 4 Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases , Shanghai, China ., Graham M; 5 CCMI EM Core Facility, Yale University School of Medicine , New Haven, Connecticut., Schettino A; 6 Yale School of Medicine , New Haven, Connecticut., Navaratnam D; 7 Department of Neurology, Yale University School of Medicine , New Haven, Connecticut.; 8 Department of Neuroscience, Yale University School of Medicine , New Haven, Connecticut., Yarbrough WG; 1 Department of Surgery, Section of Otolaryngology, Yale University School of Medicine , New Haven, Connecticut.; 9 Department of Pathology, Yale University School of Medicine , New Haven, Connecticut., Santos-Sacchi J; 1 Department of Surgery, Section of Otolaryngology, Yale University School of Medicine , New Haven, Connecticut.; 8 Department of Neuroscience, Yale University School of Medicine , New Haven, Connecticut.; 10 Department of Cellular and Molecular Physiology, Yale University School of Medicine , New Haven, Connecticut., Ivanova AV; 1 Department of Surgery, Section of Otolaryngology, Yale University School of Medicine , New Haven, Connecticut.

Publikováno v: Antioxidants & redox signaling [Antioxid Redox Signal] 2017 Sep 10; Vol. 27 (8), pp. 489-509. Date of Electronic Publication: 2017 Mar 09.