Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to Pneumocystis jirovecii pneumonia .

Autor: Amali AA; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore., Paramasivam K; Mechanobiology Institute, National University of Singapore, Singapore, Singapore., Huang CH; Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, Singapore, Singapore., Joshi A; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, United States., Hirpara JL; Cancer Science Institute, National University of Singapore, Singapore, Singapore., Ravikumar S; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore., Sam QH; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.; Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore., Tan RYM; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore., Tan Z; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore., Kumar D; Singapore Immunology Network (SIgN), ASTAR (Agency for Science, Technology and Research), Singapore, Singapore., Neckers LM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, United States., Pervaiz S; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Foo R; Cardiovascular Research Institute, National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chan CYY; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore., Zhu J; Mechanobiology Institute, National University of Singapore, Singapore, Singapore., Lee C; Cardiovascular and Metabolic Disorders, Duke NUS Medical School, Singapore, Singapore., Chai LYA; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.; Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Aug 19; Vol. 15, pp. 1423086. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).

Murine Soft Tissue Infection Model to Study Group A Streptococcus (GAS) Pathogenesis in Necrotizing Fasciitis.

Autor: Ravins M; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Ambalavanan P; Singapore-HUJ Alliance for Research and Enterprise, MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Biswas D; Singapore-HUJ Alliance for Research and Enterprise, MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Tan RYM; Singapore-HUJ Alliance for Research and Enterprise, MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Lim KXZ; Singapore-HUJ Alliance for Research and Enterprise, MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Kaufman Y; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Anand A; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Sharma A; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Hanski E; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. emanuelh@ekmd.huji.ac.il.; Singapore-HUJ Alliance for Research and Enterprise, MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, Singapore. emanuelh@ekmd.huji.ac.il.; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore. emanuelh@ekmd.huji.ac.il.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2427, pp. 185-200.

LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection.

Autor: Biswas D; Singapore-HUJ Alliance for Research and Enterprise (SHARE), MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore. Electronic address: micdb@nus.edu.sg., Ambalavanan P; Singapore-HUJ Alliance for Research and Enterprise (SHARE), MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Ravins M; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel., Anand A; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel., Sharma A; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel., Lim KXZ; Singapore-HUJ Alliance for Research and Enterprise (SHARE), MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Tan RYM; Singapore-HUJ Alliance for Research and Enterprise (SHARE), MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore., Lim HY; Department of Microbiology and Immunology, National University of Singapore, LSI Immunology Programme, National University of Singapore, Singapore, Singapore., Sol A; The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel., Bachrach G; The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel., Angeli V; Singapore-HUJ Alliance for Research and Enterprise (SHARE), MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore; Department of Microbiology and Immunology, National University of Singapore, LSI Immunology Programme, National University of Singapore, Singapore, Singapore., Hanski E; Singapore-HUJ Alliance for Research and Enterprise (SHARE), MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore; Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel. Electronic address: emanuelh@ekmd.huji.ac.il.

Publikováno v: Cell reports [Cell Rep] 2021 Mar 02; Vol. 34 (9), pp. 108766.