Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors

Autor: Rajasegaran, Lim Tk, Ong Ck, Liu Y, Teh Bt, Nicholas B. Shannon, Kon Ol, Ng G, Tan Sjj, Weng Khong Lim, Ng Wh, Ong Cj, Ng Cc, Lek Sm, Soo Kc, Chia Cs, Koh Kk, Josephine Hendrikson, Iyer Ng, Yap Dr, Tan Qx, Tan Jw

Field cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that eventually replace the epithelium, although without evidence. Through deep sequencing anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e73b2ccb0391355874022c29e4a7f7d
https://doi.org/10.21203/rs.3.rs-308860/v1

Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases.

Autor: Zhao JJ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Department of Medicine, National University Hospital, Singapore., Ong CJ; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore; SingHealth Duke-NUS Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore; Singapore Gastric Cancer Consortium, Singapore, Singapore., Srivastava S; Department of Medicine, National University of Singapore, Singapore., Chia DKA; Department of Surgery, University Surgical Cluster, National University Health System, Singapore., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Huang K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Sheng T; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Ramnarayanan K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Hagihara T; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Teo MCC; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore., Tan QX; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Ng G; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Tan JW; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Ng MCH; Division of Medical Oncology, National Cancer Centre, Singapore., Gwee YX; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Walsh R; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Law JH; Department of Surgery, University Surgical Cluster, National University Health System, Singapore., Shabbir A; Department of Surgery, University Surgical Cluster, National University Health System, Singapore., Kim G; Department of Surgery, University Surgical Cluster, National University Health System, Singapore., Tay Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Her Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore., Leoncini G; Pathology and Laboratory Medicine Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Teh BT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Hong JH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay RYK; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Teo CB; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Dings MPG; Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands., Bijlsma M; Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands., Lum JHY; Department of Pathology, National University Hospital, Singapore., Mathur S; Department of General Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore., Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Blum SM; Department of Medicine, Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts., van Laarhoven H; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands; Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands., Klempner SJ; Department of Medicine, Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts., Yong WP; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Singapore Gastric Cancer Consortium, Singapore, Singapore; Division of Medical Oncology, National Cancer Centre, Singapore., So JBY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Gastric Cancer Consortium, Singapore, Singapore; Department of Surgery, University Surgical Cluster, National University Health System, Singapore; Division of Surgical Oncology, National University Cancer Institute, Singapore., Chen Q; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore. Electronic address: qchen@imcb.a-star.edu.sg., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Singapore Gastric Cancer Consortium, Singapore, Singapore; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore; Division of Medical Oncology, National Cancer Centre, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore. Electronic address: gmstanp@duke-nus.edu.sg., Sundar R; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Singapore Gastric Cancer Consortium, Singapore, Singapore; The N.1 Institute for Health, National University of Singapore, Singapore. Electronic address: raghav.sundar@yale.edu.

Publikováno v: Gastroenterology [Gastroenterology] 2024 Dec; Vol. 167 (7), pp. 1384-1398.e4. Date of Electronic Publication: 2024 Aug 13.

[Analysis of the changes of bacterial spectrum and drug resistance in sputum culture of ICU children in a hospital of pediatric in Jiangsu Province from 2017 to 2022].

Autor: Huang H; Department of Laboratory Medicine, Children's Hospital of Soochow University, Suzhou 215025, China., Wei J; Department of Laboratory Medicine, Children's Hospital of Soochow University, Suzhou 215025, China., Shen HJ; Department of Laboratory Medicine, Children's Hospital of Soochow University, Suzhou 215025, China., Tan QX; Blood Transfusion Department, Children's Hospital of Soochow University, Suzhou 215025, China., Xue J; Department of Laboratory Medicine, Children's Hospital of Soochow University, Suzhou 215025, China., Wang C; Department of Laboratory Medicine, Children's Hospital of Soochow University, Suzhou 215025, China.

Publikováno v: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] [Zhonghua Yu Fang Yi Xue Za Zhi] 2024 Oct 06; Vol. 58 (10), pp. 1534-1540.

The immunomodulatory role of paracrine signalling factor VSIG4 in peritoneal metastases.

Autor: Chong YY; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Thiagarajan S; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Tan QX; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Lim HJ; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Tan JW; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Hendrikson J; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Ng G; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Liu Y; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Chong CYL; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Guo W; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Ngo NT; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Leow WQ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Loh T; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Sam XX; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Lim TKH; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Cai M; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Seo CJ; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Wong JSM; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Soo KC; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore., Chia CS; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore.; SingHealth Duke-NUS Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; SingHealth Duke-NUS Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Shannon NB; Department of Head and Neck Surgery, Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Ong CJ; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore. johnny.ong.c.a@singhealth.com.sg.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), National Cancer Centre Singapore, Singapore, Singapore. johnny.ong.c.a@singhealth.com.sg.; Division of Surgery and Surgical Oncology, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Singapore General Hospital, Singapore, Singapore. johnny.ong.c.a@singhealth.com.sg.; SingHealth Duke-NUS Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. johnny.ong.c.a@singhealth.com.sg.; SingHealth Duke-NUS Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. johnny.ong.c.a@singhealth.com.sg.; Institute of Molecular and Cell Biology, A*STAR Research Entities, Singapore, Singapore. johnny.ong.c.a@singhealth.com.sg.

Publikováno v: Scientific reports [Sci Rep] 2024 Jul 30; Vol. 14 (1), pp. 17522. Date of Electronic Publication: 2024 Jul 30.

Development and validation of AI models using LR and LightGBM for predicting distant metastasis in breast cancer: a dual-center study.

Autor: Zhang WH; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China., Tan Y; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Huang Z; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China., Tan QX; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China., Zhang YM; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China., Chen BJ; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China., Wei CY; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Jun 14; Vol. 14, pp. 1409273. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).