Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tan Min Chin"'
Autor:
Wen Cai Zhang, Tan Min Chin, Henry Yang, Min En Nga, Declan Patrick Lunny, Edwin Kok Hao Lim, Li Li Sun, Yin Huei Pang, Yi Ning Leow, Shanneen Rossellini Y Malusay, Priscilla Xin Hui Lim, Jeravan Zili Lee, Benedict Jian Wei Tan, Ng Shyh-Chang, Elaine Hsuen Lim, Wan Teck Lim, Daniel Shao Weng Tan, Eng Huat Tan, Bee Choo Tai, Ross Andrew Soo, Wai Leong Tam, Bing Lim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung canc
Externí odkaz:
https://doaj.org/article/a77285cd13d847d6a9987229f6e39d6d
Autor:
Dana Wai Yi Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong, Oscar M Rueda, Christopher G Smith, Dineika Chandrananda, Ross A Soo, Hong Liang Lim, Boon Cher Goh, Carlos Caldas, Tim Forshew, Davina Gale, Wei Liu, James Morris, Francesco Marass, Tim Eisen, Tan Min Chin, Nitzan Rosenfeld
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp n/a-n/a (2018)
Abstract Tumour heterogeneity leads to the development of multiple resistance mechanisms during targeted therapies. Identifying the dominant driver(s) is critical for treatment decision. We studied the relative dynamics of multiple oncogenic drivers
Externí odkaz:
https://doaj.org/article/359abd7345a3480bbf157d3f3b813302
Autor:
Azhar Ali, Elena Levantini, Jun Ting Teo, Julian Goggi, John G Clohessy, Chan Shuo Wu, Leilei Chen, Henry Yang, Indira Krishnan, Olivier Kocher, Junyan Zhang, Ross A Soo, Kishore Bhakoo, Tan Min Chin, Daniel G Tenen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
Abstract Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cells to sustain survival signals. In this report, we describe a novel oncogenic signaling pathway exclusively acting in mutated epidermal growth fa
Externí odkaz:
https://doaj.org/article/01c6764a906741acac6682d904e68f0a
Autor:
Daniel G. Tenen, Fhu Chee Wai, Elena Levantini, Thomas C. Putti, Wanjin Hong, Eva Csizmadia, Jeff Settleman, John G. Clohessy, Margaret P. Quinlan, Chen Xie, Azhar Ali, Tan Min Chin, Ellen P S Man, Boon Cher Goh, Seow-Ching Wan, Gandhi T K Boopathy, Yan Shan Ong
Publikováno v:
Theranostics
Theranostics 10 (2020): 2727–2743. doi:10.7150/thno.38729
info:cnr-pdr/source/autori:Chin T.-M.; Boopathy G.T.K.; Man E.P.S.; Clohessy J.G.; Csizmadia E.; Quinlan M.P.; Putti T.; Wan S.-C.; Xie C.; Ali A.; Wai F.C.; Ong Y.S.; Goh B.-C.; Settleman J.; Hong W.; Levantini E.; Tenen D.G./titolo:Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors/doi:10.7150%2Fthno.38729/rivista:Theranostics/anno:2020/pagina_da:2727/pagina_a:2743/intervallo_pagine:2727–2743/volume:10
Theranostics 10 (2020): 2727–2743. doi:10.7150/thno.38729
info:cnr-pdr/source/autori:Chin T.-M.; Boopathy G.T.K.; Man E.P.S.; Clohessy J.G.; Csizmadia E.; Quinlan M.P.; Putti T.; Wan S.-C.; Xie C.; Ali A.; Wai F.C.; Ong Y.S.; Goh B.-C.; Settleman J.; Hong W.; Levantini E.; Tenen D.G./titolo:Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors/doi:10.7150%2Fthno.38729/rivista:Theranostics/anno:2020/pagina_da:2727/pagina_a:2743/intervallo_pagine:2727–2743/volume:10
Oncogene-addicted cancers are predominantly driven by specific oncogenic pathways and display initial exquisite sensitivity to designer therapies, but eventually become refractory to treatments. Clear understanding of lung tumorigenic mechanisms is e
Publikováno v:
Asia-Pacific Journal of Clinical Oncology. 14:23-31
Patients with advanced stage non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations using EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib, gefitinib and afatinib as first-line treatment had better progr
Autor:
Leilei Chen, Julian L. Goggi, Elena Levantini, Chee Wai Fhu, Jun Ting Teo, Daniel G. Tenen, Chan-Shuo Wu, Tan Min Chin, Azhar Ali, John G. Clohessy
Publikováno v:
Theranostics 9 (2019): 6157–6174. doi:10.7150/thno.35805
info:cnr-pdr/source/autori:Ali A, Levantini E, Fhu CW, Teo JT, Clohessy JG, Goggi JL, Wu CS, Chen L, Chin TM, Tenen DG1./titolo:CAV1-GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer/doi:10.7150%2Fthno.35805/rivista:Theranostics/anno:2019/pagina_da:6157/pagina_a:6174/intervallo_pagine:6157–6174/volume:9
Theranostics
info:cnr-pdr/source/autori:Ali A, Levantini E, Fhu CW, Teo JT, Clohessy JG, Goggi JL, Wu CS, Chen L, Chin TM, Tenen DG1./titolo:CAV1-GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer/doi:10.7150%2Fthno.35805/rivista:Theranostics/anno:2019/pagina_da:6157/pagina_a:6174/intervallo_pagine:6157–6174/volume:9
Theranostics
Background: The development of molecular targeted therapies, such as EGFR-TKIs, has positively impacted the management of EGFR mutated NSCLC. However, patients with innate and acquired resistance to EGFR-TKIs still face limited effective therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e948e91fc4438ca64c9754088919e33f
https://publications.cnr.it/doc/417817
https://publications.cnr.it/doc/417817
Autor:
Tan Min Chin, Si-Han Sherman Ho, Woon-Khiong Chan, Yi-Cheng Ng, Kuen-Kuen Millie Lam, Shu Wang, Azhar Ali, Mei-Lin Go
Publikováno v:
ChemMedChem. 11:1944-1955
Pluripotent stem cells are uniquely positioned for regenerative medicine, but their clinical potential can only be realized if their tumorigenic tendencies are decoupled from their pluripotent properties. Deploying small molecules to remove remnant u
Publikováno v:
Oncotarget
// Si Han Sherman Ho 1, * , Azhar Ali 2, * , Tan Min Chin 2 , Mei Lin Go 1 1 Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 2 Cancer Science Institute, Yong Loo Lin School of Medicine, Singapore * These author
Autor:
Seng Weng Wong, Wei Shuen Ng, Carina Tay, Chaitanya Gupta, Yukti Choudhury, Jing Shan Lim, Tai-Chung Lam, Michelle Pek, Siu Kei Au, Yuki Sim, Wing Kin Sze, Min-Han Tan, Yew-Oo Tan, Wai Min Phyo, William Foo, Victor Hsue, Tan Min Chin, Yiliang Ho
Publikováno v:
Journal of Clinical Oncology. 38:e21516-e21516
e21516 Background: The utility of a liquid biopsy test for diagnosis and treatment is determined by its accuracy, molecular target coverage and timeliness to a clinically informative result. We describe our clinical experience of providing comprehens
Autor:
Leilei Chen, Julian L. Goggi, Ross A. Soo, Indira Krishnan, Henry Yang, Junyan Zhang, Daniel G. Tenen, Elena Levantini, Tan Min Chin, Azhar Ali, Kishore Bhakoo, Jun Ting Teo, Chan Shuo Wu, John G. Clohessy, Olivier Kocher
Publikováno v:
EMBO molecular medicine
info:cnr-pdr/source/autori:Ali A.; Levantini E.; Teo J.T.; Goggi J.; Clohessy J.G.; Wu C.S.; Chen L.; Yang H.; Krishnan I.; Kocher O.; Zhang J.; Soo R.A.; Bhakoo K.; Chin T.M.; Tenen D.G./titolo:Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer/doi:10.15252%2Femmm.201708313/rivista:EMBO molecular medicine (Print)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
EMBO Molecular Medicine
info:cnr-pdr/source/autori:Ali A.; Levantini E.; Teo J.T.; Goggi J.; Clohessy J.G.; Wu C.S.; Chen L.; Yang H.; Krishnan I.; Kocher O.; Zhang J.; Soo R.A.; Bhakoo K.; Chin T.M.; Tenen D.G./titolo:Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer/doi:10.15252%2Femmm.201708313/rivista:EMBO molecular medicine (Print)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
EMBO Molecular Medicine
Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cells to sustain survival signals. In this report, we describe a novel oncogenic signaling pathway exclusively acting in mutated epidermal growth factor rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7267c18fec2cba7b45cee79431f7047f
http://www.cnr.it/prodotto/i/425426
http://www.cnr.it/prodotto/i/425426