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Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes.

Autor: Ma YY; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Li X; Army 953 Hospital, Shigatse Branch of Xinqiao Hospital, Third Military Medical University, Shigatse, 857000, China., Yu ZY; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Luo T; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Tan CR; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Bai YD; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Xu G; Institute of Medicine and Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, 400038, China.; Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China.; Key Laboratory of High Altitude and Frigidzone Medical Support, PLA, Chongqing, 400038, China., Sun BD; Institute of Medicine and Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, 400038, China.; Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China.; Key Laboratory of High Altitude and Frigidzone Medical Support, PLA, Chongqing, 400038, China., Bu XL; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Liu YH; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Jin WS; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Gao YQ; Institute of Medicine and Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, 400038, China.; Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China.; Key Laboratory of High Altitude and Frigidzone Medical Support, PLA, Chongqing, 400038, China., Zhou XF; Suzhou Auzone Biotech, Suzhou, 215123, China.; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia., Liu J; Department of Special Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. liujuan961@163.com.; Center for Hyperbaric Oxygen Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. liujuan961@163.com., Wang YJ; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2024 Oct 03; Vol. 14 (1), pp. 415. Date of Electronic Publication: 2024 Oct 03.

Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma.

Autor: Firestone RS; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Socci ND; Department of Engineering and Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY., Shekarkhand T; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Zhu M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Qin WG; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Hultcrantz M; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY., Mailankody S; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Tan CR; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY., Korde N; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY., Lesokhin AM; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Hassoun H; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY., Shah U; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY., Maclachlan KH; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY., Rajeeve S; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Landau HJ; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Scordo M; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Shah GL; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Lahoud OB; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Giralt S; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Murata K; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Usmani SZ; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Chung DJ; Department of Medicine, Weill Cornell Medical College, New York, NY.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Publikováno v: Blood [Blood] 2024 Jul 25; Vol. 144 (4), pp. 402-407.

Patterns of CRS with teclistamab in relapsed/refractory multiple myeloma with or without prior T-cell redirection therapy.

Autor: Hamadeh IS; Clinical Pharmacy Services, Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY., Shekarkhand T; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Rueda C; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Firestone RS; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Wang AX; Clinical Pharmacy Services, Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY., Korde N; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Hultcrantz ML; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Lesokhin AM; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Mailankody S; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Hassoun H; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Shah UA; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Maclachlan K; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Rajeeve S; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Patel D; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Shah GL; Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Scordo M; Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Lahoud OB; Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Chung DJ; Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Landau HJ; Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Giralt S; Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Usmani SZ; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Tan CR; Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Publikováno v: Blood advances [Blood Adv] 2024 Jun 25; Vol. 8 (12), pp. 3038-3044.

Rejuvenation of peripheral immune cells attenuates Alzheimer's disease-like pathologies and behavioral deficits in a mouse model.

Autor: Sun PY; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Liu J; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Hu JN; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Tu YF; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Jiang Q; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Jia YJ; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Sun HL; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China.; Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Shigatse, China., Chen SH; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China.; Department of Neurology, Nanchong Central Hospital, The Second Clinical Medical School, North Sichuan Medical College, Nanchong, China., Xin JY; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Yu ZY; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Liu ZH; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Tan CR; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Zeng GH; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Shi AY; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China., Liu YH; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China.; Institute of Brain and Intelligence, Third Military Medical University, Chongqing, China., Bu XL; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China.; Institute of Brain and Intelligence, Third Military Medical University, Chongqing, China., Wang YJ; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China.; Institute of Brain and Intelligence, Third Military Medical University, Chongqing, China.; Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, China.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Wang J; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, China.

Publikováno v: Science advances [Sci Adv] 2024 May 31; Vol. 10 (22), pp. eadl1123. Date of Electronic Publication: 2024 May 29.