Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Tan A Ince"'
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 304-318 (2017)
Abstract The angiogenic factor, VEGFA, is a therapeutic target in ovarian cancer (OVCA). VEGFA can also stimulate stem‐like cells in certain cancers, but mechanisms thereof are poorly understood. Here, we show that VEGFA mediates stem cell actions
Externí odkaz:
https://doaj.org/article/0f1b4fb2289b48ca8f2cf0f945f01ce9
A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer
Autor:
Mohamed Omar, J. Chuck Harrell, Rulla Tamimi, Luigi Marchionni, Cihat Erdogan, Harikrishna Nakshatri, Tan A. Ince
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background Despite evidence indicating the dominance of cell-of-origin signatures in molecular tumor patterns, translating these genome-wide patterns into actionable insights has been challenging. This study introduces breast cancer cell-of-
Externí odkaz:
https://doaj.org/article/8a2eb70994dd4c63a4786f5a0770dfac
Autor:
Seyedeh Fatemeh Razavipour, Hyunho Yoon, Kibeom Jang, Minsoon Kim, Hend M. Nawara, Amir Bagheri, Wei-Chi Huang, Miyoung Shin, Dekuang Zhao, Zhiqun Zhou, Derek Van Boven, Karoline Briegel, Lluis Morey, Tan A. Ince, Michael Johnson, Joyce M. Slingerland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In many cancers, a stem-like cell subpopulation mediates tumor initiation, dissemination and drug resistance. Here, we report that cancer stem cell (CSC) abundance is transcriptionally regulated by C-terminally phosphorylated p27 (p27pT157pT
Externí odkaz:
https://doaj.org/article/7bf3e62bafb2439da609657ec68e47b4
Autor:
Melissa A Merritt, Stefan Bentink, Matthew Schwede, Marcin P Iwanicki, John Quackenbush, Terri Woo, Elin S Agoston, Ferenc Reinhardt, Christopher P Crum, Ross S Berkowitz, Samuel C Mok, Abigail E Witt, Michelle A Jones, Bin Wang, Tan A Ince
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80314 (2013)
The potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct cells-of-origin may play a role in determining ovarian tumor phenotype and outcome. Here we descri
Externí odkaz:
https://doaj.org/article/72352486e23d439e8ed96457071ba73e
Autor:
Kui-Jin Kim, Alzbeta Godarova, Kari Seedle, Min-Ho Kim, Tan A Ince, Susanne I Wells, James J Driscoll, Samuel Godar
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80590 (2013)
Basal-like breast carcinomas (BLCs) present with extratumoral lymphovascular invasion, are highly metastatic, presumably through a hematogenous route, have augmented expression of CD44 oncoprotein and relatively low levels of retinoblastoma (Rb) tumo
Externí odkaz:
https://doaj.org/article/080bd468a6c9468d95ba221e187be3e4
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Tumor phenotype is shaped both by transforming genomic alterations and the normal cell-of-origin. We identified a cell-of-origin associated prognostic gene expression signature, ET-9, that correlates with remarkably shorter overall and relap
Externí odkaz:
https://doaj.org/article/ef80417291074b909ff6c761bbe01a3f
Autor:
Christopher J. Kemp, Carla Grandori, Elizabeth M. Swisher, Tan A. Ince, Robert L. Diaz, Rachele Rosati, Grace Durenberger, Kay E. Gurley, Russell Moser, Reid Shaw, Goldie Y.L. Lui, Shogo Shigeta
Supplementary Figure 2. Gene Ontology (GO) enrichment analysis indicates OCI-C5x cells are more vulnerable to epigenetic interventions than OCI-P5x cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2354bb286dbcd1d1d9e63161bd05f9
https://doi.org/10.1158/1535-7163.22522126.v1
https://doi.org/10.1158/1535-7163.22522126.v1
Autor:
Christopher J. Kemp, Carla Grandori, Elizabeth M. Swisher, Tan A. Ince, Robert L. Diaz, Rachele Rosati, Grace Durenberger, Kay E. Gurley, Russell Moser, Reid Shaw, Goldie Y.L. Lui, Shogo Shigeta
Ovarian clear cell carcinoma (OCCC) is a rare, chemo-resistant subtype of ovarian cancer. To identify novel therapeutic targets and combination therapies for OCCC, we subjected a set of patient-derived ovarian cancer cell lines to arrayed high-throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ed4423984942ae5dd6f4830e5213cd
https://doi.org/10.1158/1535-7163.c.6543286.v1
https://doi.org/10.1158/1535-7163.c.6543286.v1
Autor:
Joyce M. Slingerland, Gordon B. Mills, Gao Zhang, Zhi Wei, Wei Guo, Wenbin Liu, Tan A. Ince, Dekuang Zhao, Jun Sun, Diana J. Azzam, Minsoon Kim, Karina E. Hew, Hyunho Yoon, Kibeom Jang, Fiona Simpkins
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b776babbfbbe1bc0562359c6731b56
https://doi.org/10.1158/1078-0432.22469298.v1
https://doi.org/10.1158/1078-0432.22469298.v1
Autor:
Fiona Simpkins, Joyce M. Slingerland, Gordon B. Mills, Yiling Lu, Wei Gao, Patricia Brafford, Gao Zhang, Zhi Wei, Mengnan Gu, Tan A. Ince, Alexandra H. Besser, Jun Sun, Dorraya El-Ashry, Philip C. Miller, Karina E. Hew
Supplementary Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bb84eead8700009de554900f61f323
https://doi.org/10.1158/1078-0432.22461041.v1
https://doi.org/10.1158/1078-0432.22461041.v1