Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tamuna Bolkvadze"'
Autor:
Asla Pitkänen, Noora Huusko, Xavier Ekolle Ndode-Ekane, Jenni Kyyriäinen, Anssi Lipponen, Anu Lipsanen, Alejandra Sierra, Tamuna Bolkvadze
Publikováno v:
Neurobiology of Disease, Vol 72, Iss , Pp 224-232 (2014)
Disease modification of epilepsy refers to the alleviation of epileptogenesis or comorbidities after genetic or acquired epileptogenic brain insults. There are currently 30 proof-of-concept experimental pharmacologic studies that have demonstrated so
Externí odkaz:
https://doaj.org/article/8f4ecbfa7d1043cf95c4ee94b3bed39a
Autor:
Xavier Ekolle Ndode-Ekane, Heikki Tanila, Anssi Lipponen, Laura Oliva Pérez, Jenni Kyyriäinen, Asla Pitkänen, Hennariikka Koivisto, Tamuna Bolkvadze
Publikováno v:
Epilepsy Research. 151:67-74
Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the cerebral cortex and tissue remodeling after epileptogenic brain i
Publikováno v:
Neuroscience. 415
Sushi repeat-containing protein X-linked 2 (SRPX2) is a novel hypothalamic protein and a ligand of the urokinase-type plasminogen activator receptor (uPAR), which is essential for proteolysis of extracellular matrix and tissue remodeling after an ins
Publikováno v:
Epilepsy & Behavior. 51:19-27
Several components of the urokinase-type plasminogen activator receptor (uPAR)-interactome, including uPAR and its ligand sushi-repeat protein 2, X-linked (SRPX2), are linked to susceptibility to epileptogenesis in animal models and/or humans. Recent
Autor:
Noora Huusko, Joanna K. Huttunen, Olli Gröhn, Asla Pitkänen, Riikka Immonen, Alejandra Sierra, Samuli Kemppainen, Tamuna Bolkvadze, Xavier Ekolle Ndode-Ekane
Publikováno v:
Epilepsy & Behavior. 38:19-24
Traumatic brain injury (TBI) can cause a myriad of sequelae depending on its type, severity, and location of injured structures. These can include mood disorders, posttraumatic stress disorder and other anxiety disorders, personality disorders, aggre
Publikováno v:
Epilepsybehavior : EB. 60
Binding of the extracellular matrix proteinase urokinase-type plasminogen activator (uPA) to its receptor, uPAR, regulates tissue remodeling during development and after injury in different organs, including the brain. Accordingly, mutations in the P
Publikováno v:
Neuroscience Letters. 497:163-171
Post-traumatic epilepsy (PTE) accounts for 10-20% of symptomatic epilepsies. The urgency to understand the process of post-traumatic epileptogenesis and search for antiepileptogenic treatments is emphasized by a recent increase in traumatic brain inj
Autor:
Kestutis Gurevicius, Susanna Kemppainen, Jukka Rantala, Laura Lahtinen, Heikki Tanila, Tamuna Bolkvadze, Xavier Ekolle Ndode-Ekane, Asla Pitkänen
Publikováno v:
Epilepsybehavior : EB. 42
Urokinase-type plasminogen activator (uPA), a serine protease, converts plasminogen to plasmin. Activation of plasmin leads to degradation of the extracellular matrix, which is critical for tissue recovery, angiogenesis, cell migration, and axonal an
Autor:
Jenni Kyyriäinen, Anssi Lipponen, Anu Lipsanen, Xavier Ekolle Ndode-Ekane, Tamuna Bolkvadze, Alejandra Sierra, Noora Huusko, Asla Pitkänen
Publikováno v:
Neurobiology of Disease, Vol 72, Iss, Pp 224-232 (2014)
Disease modification of epilepsy refers to the alleviation of epileptogenesis or comorbidities after genetic or acquired epileptogenic brain insults. There are currently 30 proof-of-concept experimental pharmacologic studies that have demonstrated so