Výsledky vyhledávání - "Tamson Moore"

403 Rapid and multiplexed identification of novel TCRs for TCR-T cell therapy

Autor: Tamson Moore, Bindu Hegde, John Leonard, Nathan Katz, Akshay Sharathchandra, Bryan Xie, Joanna Dreux, May Khadilkar, Marvin Gee, Leah Sibener

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09bdfa6f9cc2d2597d0c44b36c75c720
https://doi.org/10.1136/jitc-2022-sitc2022.0403

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Utilizing IL-7 to generate melanoma antigen T cell receptor-modified cells for adoptive transfer in the absence of activation

Autor: Siao-Yi Wang, Tamson Moore, Michael Nishimura, Annika Dalheim, Gina Scurti

Publikováno v: Journal of Clinical Oncology. 35:e14552-e14552

e14552 Background: Metastatic melanoma remains a fatal disease as many patients fail to respond to novel therapies. Presently, we have an ongoing trial utilizing T cell receptor (TCR)-modified cells reactive to the melanoma antigen, tyrosinase, for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1807381eae041325daa624342d30f8f7
https://doi.org/10.1200/jco.2017.35.15_suppl.e14552

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T-cell therapy in metastatic melanoma: TIL 1383I TCR transduced T cells after infusion and activity in vivo

Autor: Keisuke Shirai, Kristen E. Tobin Vealey, Joseph I. Clark, Boro Dropulic, Courtney Regan, Heather Embree, Tamson Moore, Mingli Li, Elizabeth Garrett-Mayer, Caroline Le Poole, Kelly Moxley, Ann Lau Clark, Gina Scurti, Michael Nishimura, Jonathan M. Eby

Publikováno v: Journal of Clinical Oncology. 33:3043-3043

3043 Background: Studies in adoptive T-cell transfer have suggested that persistence of the transduced T-cells is central to the viability of this therapeutic option. The objectives of this phase I...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::235d1019761151d9e5a159389fe343d8
https://doi.org/10.1200/jco.2015.33.15_suppl.3043

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Priming with very low affinity peptide ligands gives rise to CD8+ T cell effectors with enhanced function but with greater susceptibility to TGFβ-mediated suppression (63.15)

Autor: Jose-Alejandro Guevara-Patino, Jeremy O’Sullivan, Andrew Zloza, Frederick Kohlhapp, Tamson Moore, Andrew Lacek, Nickolai Dulin

Publikováno v: The Journal of Immunology. 186:63.15-63.15

While the effects of TCR affinity and TGFβ on CD8+ T cell function have been studied individually, the manner in which TCR affinity dictates susceptibility to TGFβ-mediated suppression remains unknown. To address this issue we utilized OVA altered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98728d67d1f0816e5c3fbb95adb8d233
https://doi.org/10.4049/jimmunol.186.supp.63.15

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