HBV001: Phase I study evaluating the safety and immunogenicity of the therapeutic vaccine ChAdOx1-HBV

Autor: Tamsin Cargill, Paola Cicconi, Anthony Brown, Louise Holland, Benaka Karanth, Kathryn Rutkowski, Emily Ashwin, Reena Mehta, Senthil Chinnakannan, Sarah Sebastian, Louise Bussey, Henrik Sorensen, Paul Klenerman, Thomas Evans, Eleanor Barnes

Publikováno v: JHEP Reports, Vol 5, Iss 11, Pp 100885- (2023)

Background & Aims: Millions of people worldwide are infected chronically with HBV, which results in significant morbidity and mortality. Therapeutic vaccination is a strategy that aims to induce functional cure by restoring cellular immunity to HBV.

Externí odkaz: https://doaj.org/article/a32bef9515e14869aa4bd2eed4b6b6ac

Clinical Manifestations and Long-term Outcomes of IgG4-Related Kidney and Retroperitoneal Involvement in a United Kingdom IgG4-Related Disease Cohort

Autor: Rhys D.R. Evans, Tamsin Cargill, George Goodchild, Ben Oliveira, Manuel Rodriguez-Justo, Ruth Pepper, John Connolly, Alan Salama, George Webster, Eleanor Barnes, Emma L. Culver

Publikováno v: Kidney International Reports, Vol 4, Iss 1, Pp 48-58 (2019)

Introduction: IgG4-related disease (IgG4-RD) is a relapsing multisystem fibro-inflammatory disease, which may involve the kidney (IgG4-related kidney disease [IgG4-RKD]) and retroperitoneum (IgG4-related retroperitoneal fibrosis [IgG4-RPF]). The aim

Externí odkaz: https://doaj.org/article/3829c28667ef45df814b701a8372a837

Regional variation in characteristics of patients with decompensated cirrhosis admitted to hospitals in the UK

Autor: Oliver D Tavabie, Kushala WM Abeysekera, Paul N Brennan, Thomas Marjot, Victoria T Kronsten, Wenhao Li, Jeremy S Nayagam, Amritpal Dhaliwal, Tim Hardy, James B Maurice, Nekisa Zakeri, Nadir Abbas, Abdullah Abbasi, Jane Abbott, Rahman Abdul, Mohamed Abdulaziz, Duaa Abduljabbar, Robbie Adamson, Danielle Adebayo, Aditya Kumar Adhikarla, Maciej Adler, Mostafa Afifi, Salman Ahmad, Shayan Ahmed, Guruprasad Aithal, Ali Akram, Balqees Al Radhi, Ismaeel Al-Talib, Jolomi Alele, Alaa Mohammed Ali, Safa Almusai, Victoria Appleby, Huma Asmat, Sarah Astbury, Ali Atkinson, Fakhirah Badrulhisham, Vinay K Balachandrakumar, Alexandra Ball, Moses Banfa, Jeevan Barn, Shahnaz Begum, Katherine Belfield, Oliver Bendall, Kris Bennett, William Bernal, Rajan Bhandari, Prashan Bhatti, Meg Bradley, Edward Brown, Kathleen Bryce, Ryan Buchanan, Laura Burke, Roisin Campbell, Tamsin Cargill, Geraldine Carroll, James Cartledge, Devnandan Chatterjee, Rayan Chaundry, Zeshan Choudhry, Kathleen Clare, Jeremy Cobbold, Robert Coburn, Charlotte Cook, Fintan Corvan, Rebecca Cox, Darren Craig, John Creamer, Christopher Curran, Shanika De Silva, Laurence Dean, Jayne Dillon, John Dillon, Rebecca Dunn, Robert Eckersley, Gidveig Eike, Amul Elagib, Ayman Elkholi, Omar Elshaarawy, Sarah Faloon, Francis Fan, Mohammad Fazili, Denzil Fernandes, James Fox, Matthew Foxton, Waqas Gaba, Girish Gaikwad, Abishek Gairola, Vasileios Galanakis, Charles Gallaher, Nisham Gautam, Lewis Germain, Ben Giles, Ceri Gill, Ben Glover, John Glover, David Gomez, Michael Gomez, Victoria Gordon, Sarah Gormley, John Goulder, Simran Goyal, Olivia Greenham, Sarah Guthrie, Richard Hackett, Yazan Haddadin, Andreas Hadjinicolaou, Jonathan Hall, Mohammed Hamza, Tasnuma Haque, Rebecca Harris, Catherine Hart, Sundas Hasan, Syed Mujtaba Hasnain Nadir, James Hassall, George Hawker-Bond, Jake Hawkyard, Scott Healey, Brian Hogan, Catherine Hornby, MD Humayun, John Hutchison, Zahra Iftikhar, Asem Ismail, Joel James, Rebecca Jones, Laura Jopson, Dipal Juthani, Philippa Kaina, Aadil Karim, Syed Misbah Karim, Vaishnavi Kashyap, Mohamed Kassab, Dev Katarey, Lee Kenny, Georgina Kerry, Adnan Khan, Ayesha Khan, Azab Khan, Muhammad Taha Khan, Tahir Khan, Aseil Khatib, Mohammad Fawad Khattak, Ji Jade King, Emily Kooner, Mohammed Korani, Sreelakshmi Kotha, Wai Liam Lam, Mohammed Lateef, Jess Leighton, Damien Leith, Angela Liaros, James Liu Yin, Floyd Lourenco, Annabel Lyles, Lucia Macken, Ciaran Magee, Daniel Maggs, Aarani Mahalingam, Midusa Mahenthiran, Rizwan Mahmood, Mandour Omer Mandour, Namita Manocha, Dina Mansour, Daniella Marks, Ciara Martin, Harry Martin, Iana Martin, Katherine Martin, Sachan Maruthan, Rhys Masin, Denise Mason, Charmaine Matthews, Athina Mavrou, Ema Maxan, Dominic Maxfield, Emma McAvoy, Hannah McCaughan, Kirsty McColl, Roger McCorry, Stewart McDonald, Hannah McDowell, John McGoran, Stewart McIlwane, Stuart McPherson, Olivia Meakin, Leila Mebarek, Hannah Merrill, Stephanie Michail, Pedram Modarres, Alaa Mohamedali, Yaser Mohammed, Zakiuddin Mohammed, Jaiganesh Mohan, Chloe Monnier, Eilis Moran, Francesca Moroni, Gary Morrison, Anas Msaddi, Sarah Mutar, Ismail Nahed, Janardhan Navaratnam, Luis Neto-Pereira, Jennifer Ng, Chinonso Nwoguh, Rebecca O'Kane, Sohail Omar, Abosede Ososanya, Jessiya Veliyankodan Parambil, Jay Patel, Marinos Pericleous, Zeshan Pervais, Anju Phoolchund, Julian Pietrzycki, Lushen Pillay, Keith Pohl, Kiran Prabhu, Yesita Rizky F. Putri, Umang Qazi, Khizar Khalid Rafique, Arun Raghuraman, Krithivasan Raman, Vaishali Ranade, Francesca Rastelli, Elizabeth Ratcliffe, Deepa Rattehalli, Tufail Raza, Amir Razak, George Read, Anne Robins, Ian Rowe, Simon Rushbrook, Mohamed Salama, Ramasamy Saravan, Srishti Sarkar, Emma Saunsbury, Jennifer Scott, Solange Serna, Hassnain Shahzad, Mohammed Shamsaldeen, Mohammed Sharip, Jessica Shearer, Adam Sheikh, Giovanna Sheiybani, Michelle Sherwin, Abhishek Sheth, Nidhi Shintre, Saket Singhal, Rohit Sinha, Ricky Sinharay, Gloria Smith, Ria Smith, Victoria Snowdon, Joanne Spicer, Johannes Spoor, Shiva Sreenivasan, Amar Srinivasa, Ankur Srivastava, Louise St. Aimee, Georgia Stagg, Jatinder Stanley, Jason Stevenson, Daniel Stokes, Robert Stroud, Mohsan Subhani, Hiba Suliman, Marium Sultana, Nikki Summers, Chloe Sutherland, Rachael Swann, Lynne Sykes, Mostafa Taha, Kwei Eng Tan, Zohaib Tariq, Joshua Jun Ming Tay, Alison Taylor, Amit Thakor, James Tsang, Lucy Turner, Zaccharie Tyler, Esther Unitt, Edward Volcek, Iona Watson, Chris Watters, Gemma Wells, Helen White, Monika Widlak, Matthew Williams, Jack Wischhusen, Hazel Woodland, Louise Wren, Souzana Xyda, Julian Yeh, Alison Young, Jack Shie Jie Yuan

Publikováno v: The Lancet Gastroenterology & Hepatology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb4ad3718417ecf94b996c2c5e5fcfac
https://doi.org/10.1016/s2468-1253(23)00114-0

NK cells limit therapeutic vaccine-induced CD8

Autor: Mariana O, Diniz, Anna, Schurich, Senthil K, Chinnakannan, Marion, Duriez, Kerstin A, Stegmann, Jessica, Davies, Stephanie, Kucykowicz, Kornelija, Suveizdyte, Oliver E, Amin, Frances, Alcock, Tamsin, Cargill, Eleanor, Barnes, Mala K, Maini

Publikováno v: Science translational medicine. 14(640)

A better understanding of mechanisms that regulate CD8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::787aef0d3642638d1909e5771058270b
https://pubmed.ncbi.nlm.nih.gov/35417187

Uphill or downhill bleeding?

Autor: James E. East, Brian Lei, Jonathan Marshall, Noor L Bekkali, Zillah Cargill, Tamsin Cargill

Publikováno v: Gut

An 87-year-old woman presented with a 2-day history of melaena and symptomatic anaemia. Medical history included idiopathic hyperthyroidism, a gastric ulcer and diverticular disease. On arrival, vital signs were stable apart from a tachycardia (107 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b129f8120dac8c9fa703f30c1696e625
https://doi.org/10.1136/gutjnl-2020-322298