Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Tamra E. Werbowetski-Ogilvie"'
Autor:
Stephanie Borlase, Alexandria DeCarlo, Ludivine Coudière-Morrison, Lisa Liang, Christopher J. Porter, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Sonic Hedgehog (SHH) medulloblastomas (MBs) exhibit an intermediate prognosis and extensive intertumoral heterogeneity. While SHH pathway antagonists are effective in post-pubertal patients, younger patients exhibit significant side effects,
Externí odkaz:
https://doaj.org/article/c98e2d8793f44bafba973b7abfd6007f
Autor:
Emma Martell, Helgi Kuzmychova, Esha Kaul, Harshal Senthil, Subir Roy Chowdhury, Ludivine Coudière Morrison, Agnes Fresnoza, Jamie Zagozewski, Chitra Venugopal, Chris M. Anderson, Sheila K. Singh, Versha Banerji, Tamra E. Werbowetski-Ogilvie, Tanveer Sharif
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Group 3 medulloblastoma (G3 MB) carries the worst prognosis of all MB subgroups. MYC oncoprotein is elevated in G3 MB tumors; however, the mechanisms that support MYC abundance remain unclear. Using metabolic and mechanistic profiling, we pi
Externí odkaz:
https://doaj.org/article/5c5a7943a1a04bfc88a6392559029355
Autor:
Jamie Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison, Ghazaleh M. Shahriary, Victor Gordon, Lisa Liang, Stephen Cheng, Christopher J. Porter, Rhonda Kelley, Cynthia Hawkins, Jennifer A. Chan, Yan Liang, Jingjing Gong, Carolina Nör, Olivier Saulnier, Robert J. Wechsler-Reya, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
Externí odkaz:
https://doaj.org/article/7089de720db644bf9d6c9ef8dd5e7822
Autor:
Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
Externí odkaz:
https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070
Autor:
Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie
Publikováno v:
Molecular Oncology, Vol 12, Iss 4, Pp 495-513 (2018)
Medulloblastoma (MB) is the most common malignant primary pediatric brain cancer. Among the most aggressive subtypes, Group 3 and Group 4 originate from stem/progenitor cells, frequently metastasize, and often display the worst prognosis, yet we know
Externí odkaz:
https://doaj.org/article/7bf98c7755da4eec9545cf267075d874
Autor:
Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur, Mark W. Nachtigal
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a major advance in red
Externí odkaz:
https://doaj.org/article/4d674fe80e4341f18add9d702a408c48
Autor:
Ludivine Coudière Morrison, Robyn McClelland, Christopher Aiken, Melissa Bridges, Lisa Liang, Xin Wang, Domenico Di Curzio, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 384-398 (2013)
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Major research efforts have focused on characterizing and targeting putative brain tumor stem or propagating cell populations from the tumor mass. However, less is known
Externí odkaz:
https://doaj.org/article/c705e165a84e4c54bfb64e66eae22e4e
Autor:
Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudière-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raúl A. Suárez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Bérubé, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, François Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fèvre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklós Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique López-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Iolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguía, Mario Pérezpeña, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Jüri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor
Publikováno v:
Nature, 609(7929), 1021-1028. Nature Publishing Group
Nature
Nature
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the
Autor:
Lisa Liang, Stephanie Borlase, Christopher Aiken, Kathleen Felton, Amanda Hogg, Frank van Landeghem, T. Klonisch, David D. Eisenstat, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Contemporary Clinical Neuroscience ISBN: 9783031231032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa746ada0387e8bffc93ed5b583054e
https://doi.org/10.1007/978-3-031-23104-9_19
https://doi.org/10.1007/978-3-031-23104-9_19
Autor:
Alyx B. Porter, Macarena I. de la Fuente, Sadhana Jackson, Erin M. Dunbar, Ekokobe Fonkem, Akanksha Sharma, Terri S. Armstrong, Na Tosha Gatson, Shawn L. Hervey-Jumper, Elizabeth Vera, Laura J. Klesse, Yazmin Odia, Alvina Acquaye, Alissa A. Thomas, Ugonma Chukwueke, Sandra Camelo-Piragua, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Neuro Oncol
Background Neuro-oncology has grown tremendously since 2010, marked by increasing society membership, specialized clinical expertise, and new journals. Yet, modest improvement in racial/ethnic diversity amongst clinical trial participants, researcher