Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Tamoxifen-inducible"'
Publikováno v:
Laboratory Animal Research, Vol 36, Iss 1, Pp 1-8 (2020)
Abstract Genetically engineered mouse models through gene deletion are useful tools for analyzing gene function. To delete a gene in a certain tissue temporally, tissue-specific and tamoxifen-inducible Cre transgenic mice are generally used. Here, we
Externí odkaz:
https://doaj.org/article/1e66b568bedf4d9ba75f3d4d331e04b3
Publikováno v:
Endocrine Connections, Vol 6, Iss 4, Pp 232-242 (2017)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by occurrence of parathyroid tumours and neuroendocrine tumours (NETs) of the pancreatic islets and anterior pituitary. The MEN1 gene, encoding menin, is a tum
Externí odkaz:
https://doaj.org/article/f4f4891489d34467b28c78b9be8c5bb5
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1997 Dec . 94(26), 14559-14563.
Externí odkaz:
https://www.jstor.org/stable/43657
Autor:
Abd Razak, Maizatul Fazilah
The paired-box protein PAX6 is a transcription factor that acts as a master regulator during neurodevelopment. In mice, it is expressed by neural progenitors in the cortical ventricular zone (VZ) where it regulates neurogenesis and fate specification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______463::e1f317c04e2833c4ba7ef741ee69b9b3
https://hdl.handle.net/1842/40390
https://hdl.handle.net/1842/40390
Autor:
Marion Benazra, Marie-José Lecomte, Claire Colace, Andreas Müller, Cécile Machado, Severine Pechberty, Emilie Bricout-Neveu, Maud Grenier-Godard, Michele Solimena, Raphaël Scharfmann, Paul Czernichow, Philippe Ravassard
Publikováno v:
Molecular Metabolism, Vol 4, Iss 12, Pp 916-925 (2015)
Objectives: Access to immortalized human pancreatic beta cell lines that are phenotypically close to genuine adult beta cells, represent a major tool to better understand human beta cell physiology and develop new therapeutics for Diabetes. Here we d
Externí odkaz:
https://doaj.org/article/c99264b7f4324fab94afdcac5d1b45dc
Autor:
Emilio P. Mottillo, Priya Balasubramanian, Yun-Hee Lee, Changren Weng, Erin E. Kershaw, James G. Granneman
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2276-2286 (2014)
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent and UCP1-independent processes. The present work examined de novo lipogen
Externí odkaz:
https://doaj.org/article/1eb9f31d5ec94619a83cea483bd80d27
Autor:
Marina Pasca di Magliano, Ben L. Allen, Filip Bednar, Hui-Ju Wen, Yaqing Zhang, Paloma E. Garcia, Howard C. Crawford, Michael K. Scales, Amara Z. Shaikh, Esther Kim, Yara S. El-Tawil, Maeva Adoumie, Deneen M. Wellik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)
Background & Aims Although the healthy pancreas consists mostly of epithelial cells, pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia, are characterized by an extensive accumulation of fibroinflammatory stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bb9a4858459dea9c49e9fd7caeb3bb
http://europepmc.org/articles/PMC7399194
http://europepmc.org/articles/PMC7399194
Autor:
Diana Condrea, Sirine Souali-Crespo, Betty Féret, Muriel Klopfenstein, Sylvain Faisan, Manuel Mark, Norbert B. Ghyselinck, Nadège Vernet
Publikováno v:
Cells
Cells, 2022, 11 (5), pp.891. ⟨10.3390/cells11050891⟩
Cells; Volume 11; Issue 5; Pages: 891
Cells, 2022, 11 (5), pp.891. ⟨10.3390/cells11050891⟩
Cells; Volume 11; Issue 5; Pages: 891
International audience; Retinoic acid signaling is indispensable for the completion of spermatogenesis. It is known that loss of retinoic acid nuclear receptor alpha (RARA) induces male sterility due to seminiferous epithelium degeneration. Initial g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d100d9bd3762241fd82f57809d058291
https://pubmed.ncbi.nlm.nih.gov/35269513
https://pubmed.ncbi.nlm.nih.gov/35269513
Autor:
Maeda, Yukiko, Nakamura, Eiichiro, Nguyen, Minh-Thanh, Suva, Larry J., Swain, Frances L., Razzaque, Mohammed S., Mackem, Susan, Lanske, Beate
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2007 Apr 01. 104(15), 6382-6387.
Externí odkaz:
https://www.jstor.org/stable/25427386
Autor:
Susana eMingote, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Stephen eRayport
Publikováno v:
Frontiers in Systems Neuroscience, Vol 9 (2016)
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands. Here for the first time, we have implemented this strategy to address the potentia
Externí odkaz:
https://doaj.org/article/0dddaffeafe1437387af34bb6b43a440