Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Tamotsu Yokota"'
Autor:
Keiichiro Matoba, Yosuke Nagai, Kensuke Sekiguchi, Shinji Ohashi, Etsuko Mitsuyoshi, Masayuki Shimoda, Toshiaki Tachibana, Daiji Kawanami, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Focal segmental glomerulosclerosis (FSGS) shares podocyte damage as an essential pathological finding. Several mechanisms underlying podocyte injury have been proposed, but many important questions remain. Rho-associated, coiled-coil-contain
Externí odkaz:
https://doaj.org/article/2bd38aa5657c4c588e38e29badb7fe47
Autor:
Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Kensuke Sekiguchi, Rikako Ukichi, Hiroshi Takahashi, Daisuke Aizawa, Masahiro Ikegami, Toshiaki Tachibana, Daiji Kawanami, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
ROCK2 is found to be activated in 3 diabetic models and patients with diabetes. ROCK2 deletion in podocytes protects against diabetic kidney injury, with the beneficial effect of ROCK2 inhibition observed due to rescued PPARα signaling, leading to a
Externí odkaz:
https://doaj.org/article/b37e048bbbbe44a9931bf2345ab6e519
Autor:
Keiichiro Matoba, Kensuke Sekiguchi, Yosuke Nagai, Yusuke Takeda, Hiroshi Takahashi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a critical regulator in the inception and progression of diabetic nephrop
Externí odkaz:
https://doaj.org/article/8adbfd3744e147d883a9457dcd886bc8
Autor:
Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Kensuke Sekiguchi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase that was originally identified as RhoA interacting protein. A diverse array of cellular functions, including migration, proliferation, and phenotypic modulation,
Externí odkaz:
https://doaj.org/article/0c12166862e54da1b3266ddf2e92b935
Autor:
Yusuke Takeda, Keiichiro Matoba, Kensuke Sekiguchi, Yosuke Nagai, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Biomedicines, Vol 8, Iss 7, p 182 (2020)
Diabetes is a worldwide health issue closely associated with cardiovascular events. Given the pandemic of obesity, the identification of the basic underpinnings of vascular disease is strongly needed. Emerging evidence has suggested that endothelial
Externí odkaz:
https://doaj.org/article/6ec081baae0840ae9465313de6e6ce54
Autor:
Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Biomedicines, Vol 8, Iss 2, p 40 (2020)
Diabetic kidney disease (DKD) is a worldwide public health problem. It is the leading cause of end-stage renal disease and is associated with increased mortality from cardiovascular complications. The tight interactions between redox imbalance and th
Externí odkaz:
https://doaj.org/article/9f91779f89284824b56bc04cd97700e1
Autor:
Hiroyuki Iuchi, Masaya Sakamoto, Hirofumi Suzuki, Yosuke Kayama, Kennosuke Ohashi, Takeshi Hayashi, Sho Ishizawa, Tamotsu Yokota, Katsuyoshi Tojo, Michihiro Yoshimura, Kazunori Utsunomiya
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0144921 (2016)
Increased short-term blood pressure (BP) variability on 24-hour ambulatory BP monitoring (ABPM) is known to be a risk factor for cardiovascular events. However, very few studies have evaluated the effect of salt restriction on BP variability particul
Externí odkaz:
https://doaj.org/article/7333cc617177407d80742d111570946f
Autor:
Keitaro Yokoyama, Akio Nakashima, Mitsuyoshi Urashima, Hiroaki Suga, Takeshi Mimura, Yasuo Kimura, Yasushi Kanazawa, Tamotsu Yokota, Masaya Sakamoto, Sho Ishizawa, Rimei Nishimura, Hideaki Kurata, Yudo Tanno, Katsuyoshi Tojo, Shigeru Kageyama, Ichiro Ohkido, Kazunori Utsunomiya, Tatsuo Hosoya
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51171 (2012)
We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin D (1,25OHD) levels, vitamin D receptor (VDR) polymorphisms, and renal function based on estimated glomerular filtration rate (eGFR) in patients with
Externí odkaz:
https://doaj.org/article/f6c8c0aef5c649a6828010a50cfce63e
Autor:
Yosuke Nagai, Keiichiro Matoba, Yusuke Takeda, Hideji Yako, Tomoyo Akamine, Kensuke Sekiguchi, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Kidney International. 102:536-545
Dysregulation of fatty acid utilization is increasingly recognized as a significant component of diabetic kidney disease. Rho-associated, coiled-coil-containing protein kinase (ROCK) is activated in the diabetic kidney, and studies over the past deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620b7bf415fe01005c94ac81c74037ef
https://doi.org/10.1016/j.kint.2022.04.021
https://doi.org/10.1016/j.kint.2022.04.021
Autor:
Kazunori Utsunomiya, Yusuke Takeda, Yosuke Nagai, Daiji Kawanami, Rimei Nishimura, Tamotsu Yokota, Yasushi Kanazawa, Keiichiro Matoba
Publikováno v:
JMA Journal
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and is strongly associated with cardiovascular mortality. Given the pandemic of obesity and diabetes, the elucidation of the molecular underpinnings of DKD and establishmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd8fc4e61da04b69ef59f76466cef25
http://europepmc.org/articles/PMC7590381
http://europepmc.org/articles/PMC7590381