Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Tamotsu, Yoshimori"'
Autor:
Keisuke Tabata, Kenta Imai, Koki Fukuda, Kentaro Yamamoto, Hayato Kunugi, Toshiharu Fujita, Tatsuya Kaminishi, Christian Tischer, Beate Neumann, Sabine Reither, Fatima Verissimo, Rainer Pepperkok, Tamotsu Yoshimori, Maho Hamasaki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Autophagy is a highly conserved process from yeast to mammals in which intracellular materials are engulfed by a double-membrane organelle called autophagosome and degrading materials by fusing with the lysosome. The process of autophagy is
Externí odkaz:
https://doaj.org/article/b4d8b0c4e94d4cd8bbae2e06891f916f
Autor:
Keisuke Tabata, Kenta Imai, Koki Fukuda, Kentaro Yamamoto, Hayato Kunugi, Toshiharu Fujita, Tatsuya Kaminishi, Christian Tischer, Beate Neumann, Sabine Reither, Fatima Verissimo, Rainer Pepperkok, Tamotsu Yoshimori, Maho Hamasaki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/bfd3b12725a046d6ba979c3212f5662b
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 542-545 (2022)
Externí odkaz:
https://doaj.org/article/4ba1d6d7bb8c4e8bbb048a88f3d21c28
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102236- (2023)
Summary: Autophagy is an intracellular self-degradation process in which part of the cytoplasm, aggregates, or damaged organelles are degraded in lysosomes. Lysophagy is a specific form of selective autophagy responsible for clearing damaged lysosome
Externí odkaz:
https://doaj.org/article/894bba73fa71486f960726e7d419b6eb
Autor:
Yasuhiro Akazawa, Manabu Taneike, Hiromichi Ueda, Rika Kitazume-Taneike, Tomokazu Murakawa, Ryuta Sugihara, Hiroki Yorifuji, Hiroki Nishida, Kentaro Mine, Ayana Hioki, Shigemiki Omiya, Hiroyuki Nakayama, Osamu Yamaguchi, Tamotsu Yoshimori, Yasushi Sakata, Kinya Otsu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Heart failure has high morbidity and mortality in the developed countries. Autophagy is important for the quality control of proteins and organelles in the heart. Rubicon (Run domain Beclin-1-interacting and cysteine-rich domain-containing p
Externí odkaz:
https://doaj.org/article/d95a4c18411e4cd2b66f11ef98bf7f2c
Autor:
Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. Howe
Externí odkaz:
https://doaj.org/article/156d37b505f54176b5d14d33821082db
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101539- (2022)
Summary: Senescent cells accumulation is associated with aging and age-related diseases, and recent findings suggest that autophagy, the activity of the intracellular degradation system, decreases during senescence. In this protocol, we detail steps
Externí odkaz:
https://doaj.org/article/898d9cf009e3410dac5c44839b9ad729
Autor:
Yukako Oe, Keita Kakuda, Shin-Ichiro Yoshimura, Naohiro Hara, Junya Hasegawa, Seigo Terawaki, Yasuyoshi Kimura, Kensuke Ikenaka, Shiro Suetsugu, Hideki Mochizuki, Tamotsu Yoshimori, Shuhei Nakamura
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010264 (2022)
Autophagy is an indispensable process that degrades cytoplasmic materials to maintain cellular homeostasis. During autophagy, double-membrane autophagosomes surround cytoplasmic materials and either fuse with endosomes (called amphisomes) and then ly
Externí odkaz:
https://doaj.org/article/50ae2e2999ad4446803a96263e7e291f
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101018- (2022)
Summary: Following lysosomal damage, activation and nuclear translocation of transcription factor EB (TFEB) is the key event to maintain lysosomal homeostasis. Here, we describe steps to induce lysosomal damage in HeLa cells. This can be followed by
Externí odkaz:
https://doaj.org/article/1c68051c44d64ea899bc415320be5c21
Autor:
Tadashi Yamamuro, Tsuyoshi Kawabata, Atsunori Fukuhara, Shotaro Saita, Shuhei Nakamura, Hikari Takeshita, Mari Fujiwara, Yusuke Enokidani, Gota Yoshida, Keisuke Tabata, Maho Hamasaki, Akiko Kuma, Koichi Yamamoto, Iichiro Shimomura, Tamotsu Yoshimori
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative regulator of autophagy, decreases in adipocytes with age, and its loss leads
Externí odkaz:
https://doaj.org/article/c769ddd694a94059b7f5b01f32cee145