Výsledky vyhledávání - "Tammy Sobolik"

Akademický článek

Targeting aurora kinases limits tumour growth through DNA damage‐mediated senescence and blockade of NF‐κB impairs this drug‐induced senescence

Autor: Yan Liu, Oriana E. Hawkins, Yingjun Su, Anna E. Vilgelm, Tammy Sobolik, Yee‐Mon Thu, Sara Kantrow, Ryan C. Splittgerber, Sarah Short, Katayoun I. Amiri, Jeffery A. Ecsedy, Jeffery A. Sosman, Mark C. Kelley, Ann Richmond

Publikováno v: EMBO Molecular Medicine, Vol 5, Iss 1, Pp 149-166 (2012)

Abstract Oncogene‐induced senescence can provide a protective mechanism against tumour progression. However, production of cytokines and growth factors by senescent cells may contribute to tumour development. Thus, it is unclear whether induction o

Externí odkaz: https://doaj.org/article/3ceb4ec9997e4c1aa310a31385394045

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Akademický článek

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.

Autor: Meghan M Morrison, Christian D Young, Shan Wang, Tammy Sobolik, Violeta M Sanchez, Donna J Hicks, Rebecca S Cook, Dana M Brantley-Sieders

Publikováno v: PLoS Genetics, Vol 11, Iss 7, p e1005291 (2015)

Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTOR

Externí odkaz: https://doaj.org/article/5f213725e78f4caa83a26de4ea6cc6bf

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Akademický článek

Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.

Autor: Christine M Lovly, Kimberly Brown Dahlman, Laurel E Fohn, Zengliu Su, Dora Dias-Santagata, Donna J Hicks, Donald Hucks, Elizabeth Berry, Charles Terry, MarKeesa Duke, Yingjun Su, Tammy Sobolik-Delmaire, Ann Richmond, Mark C Kelley, Cindy L Vnencak-Jones, A John Iafrate, Jeffrey Sosman, William Pao

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35309 (2012)

Knowledge of tumor mutation status is becoming increasingly important for the treatment of cancer, as mutation-specific inhibitors are being developed for clinical use that target only sub-populations of patients with particular tumor genotypes. Mela

Externí odkaz: https://doaj.org/article/c2f35af3ee7c4c6987cfa14245f98a46

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Akademický článek

IQGAP1 is a novel CXCR2-interacting protein and essential component of the 'chemosynapse'.

Autor: Nicole F Neel, Jiqing Sai, Amy-Joan L Ham, Tammy Sobolik-Delmaire, Raymond L Mernaugh, Ann Richmond

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23813 (2011)

Chemotaxis is essential for a number of physiological processes including leukocyte recruitment. Chemokines initiate intracellular signaling pathways necessary for chemotaxis through binding seven transmembrane G protein-couple receptors. Little is k

Externí odkaz: https://doaj.org/article/2bab39ab5da447f18f05055eca573578

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