Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tammy Sadler"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Immunotherapy, specifically immune checkpoint blockade (ICB), has revolutionized the treatment paradigm of triple-negative breast cancers (TNBCs). However, a subset of TNBCs devoid of tumor-infiltrating T cells (TILs) or PD-L1 expression gen
Externí odkaz:
https://doaj.org/article/2633f16e5060484d849dfcb14aa65297
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract PTEN hamartoma tumor syndrome (PHTS), caused by germline PTEN mutations, has been associated with organ-specific cancers and autism spectrum disorder (ASD) and/or developmental delay (DD). Predicting precise clinical phenotypes in any one PH
Externí odkaz:
https://doaj.org/article/36587f886d3e483098b1f4f05e9dbf59
Autor:
Thomas W. Frazier, Ritika Jaini, Robyn M. Busch, Matthew Wolf, Tammy Sadler, Patricia Klaas, Antonio Y. Hardan, Julian A. Martinez-Agosto, Mustafa Sahin, Charis Eng, the Developmental Synaptopathies Consortium
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background PTEN is a well-established risk gene for autism spectrum disorder (ASD). Yet, little is known about how PTEN mutations and associated molecular processes influence neurobehavioral function in mutation carriers with (PTEN-ASD) and
Externí odkaz:
https://doaj.org/article/d4cdaba4f0274c65bdeb0e800665007f
Autor:
Daniel L. Worthley, Rocio Lopez, Gail West, Guntram A. Grassl, Genevieve Doyon, Shardul Bhilocha, Florian Rieder, Dina Dejanovic, Satya Kurada, Ren Mao, Sara El Ouali, Claudio Fiocchi, Shuai Zhao, Paul L. Fox, Anja Schirbel, Michael Cruise, Peng Yao, Tammy Sadler, Carol A. de la Motte
Publikováno v:
Mucosal immunology
Background: Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplo
Publikováno v:
American Journal of Human Genetics
Germline heterozygous PTEN mutations cause subsets of Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome (BRRS); these subsets are characterized by high risks of breast, thyroid, and other cancers and, in one subset, autism spectrum disorder
Autor:
Julian A. Martinez-Agosto, Charis Eng, Patricia Klaas, Mustafa Sahin, Tammy Sadler, Matthew R. Wolf, Ritika Jaini, Thomas W. Frazier, Antonio Y. Hardan, Robyn M. Busch
Publikováno v:
Molecular autism, vol 12, iss 1
Molecular Autism
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Molecular Autism
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Background PTEN is a well-established risk gene for autism spectrum disorder (ASD). Yet, little is known about how PTEN mutations and associated molecular processes influence neurobehavioral function in mutation carriers with (PTEN-ASD) and without A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cfc696ac92835b2adbc1f4ed24d895
https://escholarship.org/uc/item/2nk6q215
https://escholarship.org/uc/item/2nk6q215
Autor:
Tammy Sadler, Florian Rieder, Nancy Rebert, Claudio Fiocchi, Christoph Wagener, Anja Schirbel, Andreas Sturm, Gail West, Carol A. de la Motte, Andrea Kristina Horst
Publikováno v:
Inflammatory bowel diseases. 25(2)
Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) displays multiple activities, among which pathogen binding and angiogenesis are particularly prominent. These same functions are also exerted by Toll- and NOD-like recepto
Autor:
Sean P. Kessler, Craig R. Homer, Gail West, Melania Scarpa, Claudio Fiocchi, Carol A. de la Motte, Eleni Stylianou, Christine McDonald, Tammy Sadler
Publikováno v:
The American Journal of Pathology. 185:1624-1637
Intestinal epithelial cell (IEC) death is typical of inflammatory bowel disease (IBD). We investigated: i) whether IEC–released necrotic cell products (proinflammatory mediators) amplify mucosal inflammation, ii) the capacity of necrotic cell lysat
Publikováno v:
Inflammatory Bowel Diseases. 19:1354-1364
Background Fibrosis of the intestine is currently an irreversible complication of inflammatory bowel disease; yet, little is understood of the underlying pathogenesis and antifibrotic strategies remain elusive. To develop effective therapies, knowled
Autor:
Tammy Sadler, Shardul Bhilocha, Carol A. de la Motte, Banu Gopalan, Eleni Stylianou, Sean P. Kessler, Florian Rieder, Claudio Fiocchi, Gail West
Publikováno v:
The American Journal of Pathology. 179:2660-2673
In addition to mesenchymal cells, endothelial cells may contribute to fibrosis through the process of endothelial-to-mesenchymal transition (EndoMT). We investigated whether human intestinal microvascular endothelial cells (HIMEC) undergo EndoMT and