Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study

Autor: Peter Korsten, Timothy B. Niewold, Michael Zeisberg, Tammy O. Utset, Daniel Cho, Lawrence S. Zachary, Nadera J. Sweiss, Suncica Volkov

Publikováno v: Autoimmune Diseases, Vol 2017 (2017)

Objective. To investigate the role of whole blood viscosity in digital ulcer (DU) development in patients with diffuse and limited Systemic sclerosis. Methods. A convenience sample of patients with Systemic sclerosis (SSc) was selected from the adult

Externí odkaz: https://doaj.org/article/8e20b83ae85a4ddab4839763910c9b23

Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus

Autor: Yelena Koldobskaya, Kichul Ko, Akaash A. Kumar, Sandra Agik, Jasmine Arrington, Silvia N. Kariuki, Beverly S. Franek, Marissa Kumabe, Tammy O. Utset, Meenakshi Jolly, Andrew D. Skol, Timothy B. Niewold

Publikováno v: Clinical and Developmental Immunology, Vol 2012 (2012)

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disorder characterized by differences in autoantibody profiles, serum cytokines, and clinical manifestations. We have previously conducted a case-case genome-wide association stu

Externí odkaz: https://doaj.org/article/8de1dfd2d8db4ccdbaba4a420e94f627

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans

Autor: Daniel J. Wallace, John D. Reveille, Alexander T. Dilthey, Jeffrey C. Edberg, Michael H. Weisman, Kenneth M. Kaufman, Betty P. Tsao, Marta E. Alarcón-Riquelme, Lindsey A. Criswell, Rosalind Ramsey-Goldman, Patrick M. Gaffney, Graciela S. Alarcón, Kathy L. Sivils, Carl D. Langefeld, Timothy J. Vyse, Jane E. Salmon, John B. Harley, Ken B. Hanscombe, Diane L. Kamen, Hal Scofield, Janelle A. Noble, Robert P. Kimberly, Mary E. Comeau, Joan T. Merrill, Cathryn M. Lewis, David L. Morris, Judith A. James, Gary S. Gilkeson, Tammy O. Utset, Elizabeth E. Brown, Chaim O. Jacob, Philip Tombleson, Jennifer A. Kelly, Michelle Petri, Joseph M. McCune, Jennifer A. Croker

Publikováno v: Human Molecular Genetics
Hanscombe, K B, Morris, D L, Noble, J A, Dilthey, A T, Tombleson, P, Kaufman, K M, Comeau, M, Langefeld, C D, Alarcon-Riquelme, M E, Gaffney, P M, Jacob, C O, Sivils, K L, Tsao, B P, Alarcon, G S, Brown, E E, Croker, J, Edberg, J, Gilkeson, G, James, J A, Kamen, D L, Kelly, J A, McCune, J, Merrill, J T, Petri, M, Ramsey-Goldman, R, Reveille, J D, Salmon, J E, Scofield, H, Utset, T, Wallace, D J, Weisman, M H, Kimberly, R P, Harley, J B, Lewis, C M, Criswell, L A & Vyse, T J 2018, ' Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans ', Human Molecular Genetics, vol. 27, no. 21, 27(21), pp. 3813-3824 . https://doi.org/10.1093/hmg/ddy280

Genetic variation within the major histocompatibility complex (MHC) contributes substantial risk for systemic lupus erythematosus, but high gene density, extreme polymorphism and extensive linkage disequilibrium (LD) have made fine mapping challengin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47feb1959642e2e3cc3091e1856ab6f
http://europepmc.org/articles/PMC6196648

OP0167 SUCCESSFUL WITHDRAWAL OF MYCOPHENOLATE MOFETIL IN QUIESCENT SLE: RESULTS FROM A RANDOMIZED TRIAL

Autor: Gabriel Contreras, Judith A. James, Diane L. Kamen, Eliza F. Chakravarty, J. Springer, Tammy O. Utset, Cynthia Aranow, Kenneth C. Kalunian, Ellen Goldmuntz, Ashley Pinckney, B. Barry, Megan E.B. Clowse, W J McCune, Lynette Keyes-Elstein

Publikováno v: Annals of the Rheumatic Diseases. 79:105-106

Background:Trials and clinical observations have demonstrated the efficacy of mycophenolate mofetil (MMF) for SLE treatment. Long-term use of MMF is associated with adverse events, pregnancy risks, drug monitoring, and increased cost. Current managem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb8cd099b5100d58c7380fb2b2f72b55
https://doi.org/10.1136/annrheumdis-2020-eular.5110

Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study

Autor: Brad H. Rovin, David Wofsy, Gabriel Contreras, Anne Davidson, Mary Anne Dooley, Cesar Ramos-Remus, Jorge Sánchez-Guerrero, Anca Askanase, Dawn E. Smilek, Lynette Keyes-Elstein, Nancy J. Olsen, Patti Tosta, Tammy O. Utset, Wendy Gao, Diane L. Kamen, Hilda Fragoso-Loyo, Maria Dall'Era, Betty Diamond, Margie Byron, David I. Daikh, W. Joseph McCune, Patricia Cagnoli, Kenneth C. Kalunian, Marc C. Levesque, Meggan Mackay, Iris Lee, Swamy Venuturupalli, David R. Karp, Meenakshi Jolly, W. Winn Chatham, Linna Ding, S. Sam Lim, Robert Winchester, Peter H. Sayre

Publikováno v: Arthritis & Rheumatology. 66:3096-3104

Objective To assess the efficacy and safety of a 24-week course of abatacept in the treatment of active lupus nephritis. An additional exploratory objective was to assess the potential of abatacept to induce ‘clinical tolerance’, defined as susta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db62f99f98fd8135358b4c50aa71e352
https://doi.org/10.1002/art.38790