Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tammy, Bigwarfe"'
Autor:
Peng, Sun, Christina S, Bartlett, Chao, Zheng, Tammy, Bigwarfe, Joshuaine M, Grant, Margit, MacDougall, Valentina, Berger, Steven, Kerr, Hu Sheng, Qian, Mark, McHugh, Hongxing, Chen, Xiaomei, Zhang, Miranda L, Carpenter, Heather N, Robinson, John, Miglietta, Thorsten, Lamla, Ryan M, Fryer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:266-276
Diabetic nephropathy is a leading cause of end-stage renal disease, characterized by endothelial dysfunction and a compromised glomerular permeability barrier. Dysregulation of the angiopoietin 1 (ANGPT1)/angiopoietin 2 (ANGPT2) signaling axis is imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374bd8d82a45deba15901277988434a3
https://doi.org/10.1124/jpet.121.001067
https://doi.org/10.1124/jpet.121.001067
Application of Mitra® microsampling for pharmacokinetic bioanalysis of monoclonal antibodies in rats
Publikováno v:
Bioanalysis. 11:13-20
Aim: Volumetric absorptive microsampling (VAM) is being increasingly applied in nonclinical pharmacokinetic studies. Although there are published results for VAM use in small molecule pharmacokinetics (PK) studies, there is limited data on the utilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7eebcc09aa9396d22f947aa152563bd
https://doi.org/10.4155/bio-2018-0228
https://doi.org/10.4155/bio-2018-0228
Autor:
David B. Hayes, Ryan M. Fryer, Rachel Kroe-Barrett, Sanjaya Singh, James D. Smith, Peng Sun, Margit MacDougall, Kristin Bovat, Joshuaine Toth, Kavita Jerath, Chao Zheng, Tammy Bigwarfe
Publikováno v:
mAbs
Ang1 is a soluble ligand to receptor Tie2, and increasing the circulating Ang1 level may improve vascular stabilization under certain disease conditions. Here, we found that the circulating Ang1 level was significantly increased in cynomolgus monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8f100ac1c7308df1c03be75ebc9bb4
https://doi.org/10.1080/19420862.2018.1521130
https://doi.org/10.1080/19420862.2018.1521130
Autor:
Erica Waltz, Rachel Kroe-Barrett, Tammy Bigwarfe, Sarah Low, John Miglietta, Hua Li, Cynthia Hess Kenny, Maria Myzithras, Jennifer Ahlberg, Irina Rybina
Publikováno v:
Bioanalysis. 10:397-406
Aim: The fully automated microfluidics-based Gyrolab is a popular instrument for the bioanalysis of protein therapeutics; requiring minimal sample and reagent volumes. Gyros offers affinity software for determining binding affinity in solution using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d754d041ec368ad7e12747657cf77d90
https://doi.org/10.4155/bio-2017-0251
https://doi.org/10.4155/bio-2017-0251
Autor:
Maria Myzithras, Erica Waltz, Irina Rybina, Zhong-Fu Huang, Jennifer Ahlberg, Tammy Bigwarfe, Haiguang Xiao, Rachel Kroe-Barrett, Marcio O. Lasaro, Himanshu Saraf, Simon Roberts, Cynthia Hess Kenny, Danlin Yang, Steven Castellano, Sanjaya Singh, Craig Giragossian
Publikováno v:
mAbs
Antibodies with pH-dependent binding to both target antigens and neonatal Fc receptor (FcRn) provide an alternative tool to conventional neutralizing antibodies, particularly for therapies where reduction in antigen level is challenging due to high t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eac44c654c862fa41923786e5554e5
https://doi.org/10.1080/19420862.2017.1359455
https://doi.org/10.1080/19420862.2017.1359455
Autor:
Hua Li, Simon Roberts, Craig Giragossian, Erica Waltz, Jennifer Ahlberg, Maria Myzithras, Tammy Bigwarfe
Publikováno v:
mAbs. 8:1606-1611
Prior to clinical studies, the pharmacokinetics (PK) of antibody-based therapeutics are characterized in preclinical species; however, those species can elicit immunogenic responses that can lead to an inaccurate estimation of PK parameters. Immunode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a926c14ce35011ce4da77d1401d72b
https://doi.org/10.1080/19420862.2016.1229721
https://doi.org/10.1080/19420862.2016.1229721
Publikováno v:
Bioanalysis. 11(1)
Volumetric absorptive microsampling (VAM) is being increasingly applied in nonclinical pharmacokinetic studies. Although there are published results for VAM use in small molecule pharmacokinetics (PK) studies, there is limited data on the utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b06beb03a467f566e83f142abe8945a
https://pubmed.ncbi.nlm.nih.gov/30461295
https://pubmed.ncbi.nlm.nih.gov/30461295
Autor:
Hua Li, Scott M. MacDonnell, Sarah Low, Priyanka Gupta, Simon Roberts, Tammy Bigwarfe, Michael Franti, David B. Hayes, Jennifer Ahlberg, Maria Myzithras, Erica Waltz
Publikováno v:
Bioanalysis. 8(6)
Background: Four bioanalytical platforms were evaluated to optimize sensitivity and enable detection of recombinant human GDF11 in biological matrices; ELISA, Meso Scale Discovery, Gyrolab xP Workstation and Simoa HD-1. Results & methodology: After c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e5f85d770b8ea9290ec7626b85321a
https://pubmed.ncbi.nlm.nih.gov/26917343
https://pubmed.ncbi.nlm.nih.gov/26917343
Autor:
Kerry L. M. Ralph, Mark Panzenbeck, Haiguang Xiao, Lee Frego, Tammy Bigwarfe, Erica Waltz, Christine Grimaldi, Kathy Last-Barney, Don Souza, Scott Brodeur, Gerald Nabozny, Jay S. Fine, Jorg H. W. Distler, Meera Ramanujam
Publikováno v:
The Journal of Immunology. 196:70.19-70.19
Targeting CD40-CD40L interactions has been an interesting drug concept for the treatment of autoimmune diseases given this pathway’s role in the development of both humoral and cell mediated immune responses. While preclinical blockade of CD40L is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a6c1ff851a90799154c339ba0d6cf8
https://doi.org/10.4049/jimmunol.196.supp.70.19
https://doi.org/10.4049/jimmunol.196.supp.70.19
Publikováno v:
Journal of immunotoxicology. 10(1)
Functional innate immune assessments, including phagocytosis and respiratory burst, are at the forefront of immunotoxicology evaluation in pre-clinical animal species. Although in the clinic and in academic science, phagocytosis, and respiratory burs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6870252b6eca8ebcdbeefa4777786ce6
https://pubmed.ncbi.nlm.nih.gov/23173903
https://pubmed.ncbi.nlm.nih.gov/23173903