Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tammie R. Covington"'
Publikováno v:
Toxics, Vol 11, Iss 2, p 187 (2023)
An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded
Externí odkaz:
https://doaj.org/article/d7d3289f956e400badbd938c9d3d9d5f
Sensitivity and Monte Carlo analyses are integral parts of uncertainty and variability analysis of physiologically-based pharmacokinetic (PBPK) models. Both may be used to assess the impact of parameter uncertainty and variability on model output; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ae13faebdfd9a81cc407240d475089
https://doi.org/10.1016/b978-0-12-818596-4.00009-6
https://doi.org/10.1016/b978-0-12-818596-4.00009-6
Autor:
Jerry L. Campbell, Yi-Hsien Cheng, Wei-Chun Chou, H.J. Clewell, Tammie R. Covington, A.Y. Efremenko, Corie A. Ellison, Jeffrey W. Fisher, Jeffery M. Gearhart, C.E. Hack, Sami Haddad, N. Hewitt, Conrad Housand, Shruti V. Kabadi, Miao Li, Zhoumeng Lin, Darshan Mehta, A. Najjar, Andy Nong, S.N. Pendse, Christopher Ruark, A. Schepky, Lisa M. Sweeney, Xiaoxia Yang, Miyoung Yoon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a68691a9f72220a2cc6093218841c0a4
https://doi.org/10.1016/b978-0-12-818596-4.00019-9
https://doi.org/10.1016/b978-0-12-818596-4.00019-9
Autor:
Tammie R. Covington, Christopher D. Ruark, Edward D. Clarkson, Christopher E. Whalley, Jeffery M. Gearhart, Lucille A. Lumley
In order to improve the risk estimates for VX exposures, the pharmacodynamics and, consequently, the pharmacokinetics must be better understood. Physiologically based pharmacokinetic–pharmacodynamic (PBPK-PD) models have proven to be useful analyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9011f16c99d1bd1b613f77aef252c50b
https://doi.org/10.1039/9781782622413-00213
https://doi.org/10.1039/9781782622413-00213
Autor:
Justin G. Teeguarden, Andy Nong, Tammie R. Covington, Melvin E. Andersen, J.M. Gearhart, Harvey J. Clewell
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 70:1515-1526
Manganese (Mn), an essential metal nutrient, produces neurotoxicity in workers exposed chronically to high concentrations of Mn-containing dusts. Our long-term goal was to develop a physiologically based pharmacokinetic (PBPK) model to support health
Autor:
Justin G. Teeguarden, Melvin E. Andersen, Harvey J. Clewell, David C. Dorman, Tammie R. Covington
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 70:1493-1504
Homeostatic mechanisms controlling uptake, storage, and elimination of dietary manganese (Mn) afford protection against fluctuations in tissue manganese (Mn) levels. Homeostatic control of inhaled Mn is less well understood, but important in assessin
Autor:
Melvin E. Andersen, Justin G. Teeguarden, Harvey J. Clewell, David C. Dorman, Tammie R. Covington, Andy Nong
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 70:1505-1514
Current concerns regarding inhalation exposure to Mn, a component from oxidation of the gasoline antiknock agent MMT, have stimulated interest in developing kinetic tools for describing the inhalation and combined inhalation/oral route kinetics of Mn
Autor:
Harvey J. Clewell, Cynthia Van Landingham, Janet E. Kester, Tammie R. Covington, P. Robinan Gentry, Melvin E. Andersen
Publikováno v:
Regulatory Toxicology and Pharmacology. 47:1-18
The current Public Health Goal (PHG) for perchloroethylene (PCE) was derived using upper-bound estimates of fractional PCE metabolism in humans. These estimates were in part obtained from a published evaluation of the uncertainty and variability in h
Autor:
Justin G. Teeguarden, Hugh A. Barton, Tammie R. Covington, John M. Waechter, Harvey J. Clewell
Publikováno v:
Toxicological Sciences. 85:823-838
Bisphenol A (BPA) is a weakly estrogenic monomer used in the production of polycarbonate plastic and epoxy resins, both of which are used in food contact and other applications. A physiologically based pharmacokinetic (PBPK) model of BPA pharmacokine
Autor:
Harvey J. Clewell, Dori R. Germolec, P. Robinan Gentry, Tammie R. Covington, Greg Lawrence, Elizabeth T. Snow, Tracy B. McDonald, Glenda J. Moser, Janice W. Yager
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 68:329-351
Several chronic bioassays have been conducted in multiple strains of mice in which various concentrations of arsenate or arsenite were administered in the drinking water without a tumorigenic effect. However, one study (Ng et al., 1999) reported a si