A genetic hazard score to personalize prostate cancer screening, applied to population data

Autor: Keith W. Muir, Amanda B. Spurdle, Anders M. Dale, J K Parsons, Ian G. Mills, D J Schaid, Rosalind A. Eeles, Wojciech Kluzniak, Jenny L Donovan, Andrzej M. Kierzek, C. Slavov, Csilla Sipeky, P Pharoah, Henrik Grönberg, Chun Chieh Fan, Jyotsna Batra, B.G. Nordestgaard, Emma L Turner, F. Wiklund, Jong Y. Park, Johanna Schleutker, Manuel Luedeke, Eleanor I Walsh, Tyler M. Seibert, Zsofia Kote-Jarai, Manuel R. Teixeira, Tammela Tlj., T A Sellers, Freddie C. Hamdy, W. Vogel, Judith A. Clements, Cezary Cybulski, Shannon K. McDonnell, Richard M. Martin, Kathleen Herkommer, Lin H-Y., Olama Aaa., Bernd Holleczek, Huynh-Le M-P., Nora Pashayan, Timothy J. Key, H Brenner, Lisa A. Cannon-Albright, Hardev Pandha, Ruth C. Travis, Dominika Wokołorczyk, Adam S. Kibel, Markus Aly, Doug Easton, Paula Paulo, Ole A. Andreassen, David E. Neal, J A Lane, S. N. Thibodeau, Khaw K-T., Roshan Karunamuni, Ben Schöttker, Vanio Mitev, Sara Benlloch Garcia, Radka Kaneva, Sofia Maia, Christiane Maier, Agnieszka Michael

BackgroundGenetic risk stratification may inform decisions of whether—and when—a man should undergo prostate cancer (PCa) screening. We previously validated a polygenic hazard score (PHS), a weighted sum of 54 single-nucleotide polymorphism genot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4185dbfa6c0a316f465fe6175dce9f9e
https://doi.org/10.1101/619718

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Autor: Robert J. Hamilton, Douglas F. Easton, Suzanne K. Chambers, Edward Giovannucci, Henrik Grönberg, Artitaya Lophatananon, Niclas Håkansson, Sue A. Ingles, Markus Aly, Antonio Gómez-Caamaño, B. E. Henderson, Samantha E.T. Larkin, Manuel Luedeke, Fredrick R. Schumacher, Zan Sun, Karina Dalsgaard Sørensen, Jasmine Lim, Marija Gamulin, Lu Y-J., Meir J. Stampfer, Shannon K. McDonnell, Maria Elena Martinez, Harry Ostrer, Piet Ost, Michael Borre, Monique J. Roobol, F Canzian, D J Schaid, Lin H-Y., Rasmus Bisbjerg, Judith A. Clements, Ezequiel Anokian, Martin Andreas Røder, Ed Saunders, Agnieszka Michael, G Jenster, Bernd Holleczek, Guomin Wang, Jakub Lubiński, Jeri Kim, Genetic Associations, Rosalind A. Eeles, Yves Akoli Koudou, Gemma Castaño-Vinyals, Jing Ma, Leire Moya, Sonja I. Berndt, Thérèse Truong, Maren Weischer, Robert Szulkin, T. Van Den Broeck, Davor Lessel, Børge G. Nordestgaard, Chee Goh, Torben F. Ørntoft, Manolis Kogevinas, Catherine M. Tangen, Gerald L. Andriole, Robert N. Hoover, Ana Vega, Stephanie J. Weinstein, West Cml., Tomislav Kuliš, Neil Fleshner, Graham G. Giles, Barry S. Rosenstein, Z Cui, Marta Cardoso, Tokhir Dadaev, Jenny L Donovan, David E. Neal, Richard M. Martin, Tyrer Jp, Thomas J. Schnoeller, Sandeep Singhal, Clara Cieza-Borrella, Ian M. Thompson, Lisa A. Cannon-Albright, Jong Y. Park, Johanna Schleutker, Brian D. Carter, Esther M. John, Christiane Maier, Matthew Parliament, Antonio Finelli, Mark N. Brook, Gail P. Risbridger, Xin Guo, Lisa G. Horvath, Daniel W. Lin, Mariana C. Stern, Tobias Nordström, Demetrius Albanes, Melissa C. Southey, Zhang H-W., Liesel M. FitzGerald, Christopher I. Amos, Freddie C. Hamdy, P Pharoah, Wayne D. Tilley, Susan M. Gapstur, Teo S-H., Claire Aukim-Hastie, Christopher J. Logothetis, Elio Riboli, Bettina F. Drake, Csilla Sipeky, Alicja Wolk, Cezary Cybulski, Joe Dennis, Olama Aaa., Hermann Brenner, Lorelei A. Mucci, Yuan Chun Ding, L E Beane Freeman, Stella Koutros, G De Meerleer, A. Siddiq, Lisa F. Newcomb, Mitchell J. Machiela, Munaza Ahmed, Jyotsna Batra, Susan L. Neuhausen, Christopher A. Haiman, Stephen J. Chanock, T A Sellers, Florence Menegaux, David V. Conti, Lovise Maehle, O. Cussenot, Neil G. Burnet, Nora Pashayan, Timothy J. Key, P Iversen, Hardev Pandha, Katarina Cuk, David J. Hunter, Khaw K-T., Janet L. Stanford, Loic Le Marchand, Javier Llorca, Steven Joniau, Elaine A. Ostrander, Sarah L. Kerns, van Schaik Rhn., Adam S. Kibel, Robert J. MacInnis, Tammela Tlj., Sune F. Nielsen, Constance Turman, Peter Kraft, Laurence N. Kolonel, Nawaid Usmani, K. De Ruyck, Sara Benlloch, C. Slavov, Azad Hassan Abdul Razack, Milan S. Geybels, Jianfeng Xu, Phyllis J. Goodman, Martin Eklund, Alison M. Dunning, Radka Kaneva, Paul A. Townsend, Kenneth Muir, Manuel R. Teixeira, Sara Lindström, Geraldine Cancel-Tassin, Mechanisms in Oncology, Anssi Auvinen, Victoria L. Stevens, Laura Fachal, Stephen N. Thibodeau, Linda Steele, Manuela Gago-Dominguez, Frank Claessens, Kathryn L. Penney, Fredrik Wiklund, Eli Marie Grindedal, Xin Sheng, Ruth C. Travis, Zsofia Kote-Jarai, Dominika Wokołorczyk, D. Leongamornlert, Paula Paulo, Xueying Mao, Vanio Mitev, Jose Esteban Castelao, Ninghan Feng

Publikováno v: Nature genetics. 51(2)

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls

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https://pubmed.ncbi.nlm.nih.gov/29892016

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Autor: Dadaev, T, Saunders, EJ, Newcombe, PJ, Anokian, E, Leongamornlert, DA, Brook, MN, Cieza-Borrella, C, Mijuskovic, M, Wakerell, S, Olama, AAA, Schumacher, FR, Berndt, SI, Benlloch, S, Ahmed, M, Goh, C, Sheng, X, Zhang, Z, Muir, K, Govindasami, K, Lophatananon, A, Stevens, VL, Gapstur, SM, Carter, BD, Tangen, CM, Goodman, P, Thompson, IM, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, TLJ, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Hakansson, N, West, C, Dunning, AM, Burnet, N, Mucci, L, Giovannucci, E, Andriole, G, Cussenot, O, Cancel-Tassin, G, Koutros, S, Freeman, LEB, Sorensen, KD, Orntoft, TF, Borre, M, Maehle, L, Grindedal, EM, Neal, DE, Donovan, JL, Hamdy, FC, Martin, RM, Travis, RC, Key, TJ, Hamilton, RJ, Fleshner, NE, Finelli, A, Ingles, SA, Stern, MC, Rosenstein, B, Kerns, S, Ostrer, H, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Guo, X, Wang, G, Sun, Z, Giles, GG, Southey, MC, Macinnis, RJ, Fitzgerald, LM, Kibel, AS, Drake, BF, Vega, A, Gómez-Caamaño, A, Fachal, L, Szulkin, R, Eklund, M, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Penney, KL, Stampfer, M, Park, JY, Sellers, TA, Lin, H-Y, Stanford, JL, Cybulski, C, Wokolorczyk, D, Lubinski, J, Ostrander, EA, Geybels, MS, Nordestgaard, BG, Nielsen, SF, Weisher, M, Bisbjerg, R, Røder, MA, Iversen, P, Brenner, H, Cuk, K, Holleczek, B, Maier, C, Luedeke, M, Schnoeller, T, Kim, J, Logothetis, CJ, John, EM, Teixeira, MR, Paulo, P, Cardoso, M, Neuhausen, SL, Steele, L, Ding, YC, De Ruyck, K, De Meerleer, G, Ost, P, Razack, A, Lim, J, Teo, S-H, Lin, DW, Newcomb, LF, Lessel, D, Gamulin, M, Kulis, T, Kaneva, R, Usmani, N, Slavov, C, Mitev, V, Parliament, M, Singhal, S, Claessens, F, Joniau, S, Van Den Broeck, T, Larkin, S, Townsend, PA, Aukim-Hastie, C, Gago-Dominguez, M, Castelao, JE, Martinez, ME, Roobol, MJ, Jenster, G, Van Schaik, RHN, Menegaux, F, Truong, T, Koudou, YA, Xu, J, Khaw, K-T, Cannon-Albright, L, Pandha, H, Michael, A, Kierzek, A, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Lindstrom, S, Turman, C, Ma, J, Hunter, DJ, Riboli, E, Siddiq, A, Canzian, F, Kolonel, LN, Le Marchand, L, Hoover, RN, Machiela, MJ, Kraft, P, Consortium, Practical (Prostate Cancer Association Group To Investigate Cancer-Associated Alterations In The Genome), Freedman, M, Wiklund, F, Chanock, S, Henderson, BE, Easton, DF, Haiman, CA, Eeles, RA, Conti, DV, Kote-Jarai, Z

Publikováno v: Nature Communications, 9:2256. Nature Publishing Group
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
NATURE COMMUNICATIONS

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0bf073e818a65d824db9940163b4958c
https://www.repository.cam.ac.uk/handle/1810/278592

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Autor: Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, HW, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA, Nemesure, B, Isaacs, WB, Zheng, W, Pettaway, CA, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, John, EM, Murphy, AB, Signorello, LB, Carpten, J, Leske, MC, Wu, S-Y, Hennis, AJM, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Witte, JS, Casey, G, Kaggwa, S, Cook, MB, Stram, DO, Blot, WJ, Eeles, RA, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Gronberg, H, Wiklund, F, Aly, M, Henderson, BE, Schleutker, J, Wahlfors, T, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, P, Pashayan, N, Khaw, K-T, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Teerlink, C, Brenner, H, Dieffenbach, AK, Arndt, V, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, JA, Teixeira, MR, Pandha, H, Michael, A, Paulo, P, Maia, S, Kierzek, A, Conti, DV, Albanes, D, Berg, C, Berndt, SI, Campa, D, Crawford, ED, Diver, WR, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hoover, R, Hunter, DJ, Johansson, M, Kraft, P, Le Marchand, L, Lindstrom, S, Navarro, C, Overvad, K, Riboli, E, Siddiq, A, Stevens, VL, Trichopoulos, D, Vineis, P, Yeager, M, Trynka, G, Raychaudhuri, S, Schumacher, FR, Price, AL, Freedman, ML, Haiman, CA, Pasaniuc, B, Cook, M, Guy, M, Govindasami, K, Leongamornlert, D, Sawyer, EJ, Wilkinson, R, Saunders, EJ, Tymrakiewicz, M, Dadaev, T, Morgan, A, Fisher, C, Hazel, S, Livni, N, Lophatananon, A, Pedersen, J, Hopper, JL, Adolfson, J, Stattin, P, Johansson, J-E, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Auvinen, A, Kujala, P, Maeaettaenen, L, Murtola, T, Taari, K, Weischer, M, Nielsen, SF, Klarskov, P, Roder, A, Iversen, P, Wallinder, H, Gustafsson, S, Cox, A, Brown, P, George, A, Marsden, G, Lane, A, Davis, M, Tillmans, L, Riska, S, Wang, L, Rinckleb, A, Lubiski, J, Stegmaier, C, Pow-Sang, J, Park, H, Radlein, S, Rincon, M, Haley, J, Zachariah, B, Kachakova, D, Popov, E, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Heathcote, P, Wood, G, Malone, G, Saunders, P, Eckert, A, Yeadon, T, Kerr, K, Collins, A, Turner, M, Srinivasan, S, Kedda, M-A, Alexander, K, Omara, T, Wu, H, Henrique, R, Pinto, P, Santos, J, Barros-Silva, J, Consortium, PRACTICAL

Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European

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https://eprints.whiterose.ac.uk/101528/1/ncomms10979.pdf

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Autor: Cao G-W., Joanne L. Dickinson, Gianluca Severi, Tokhir Dadaev, Alan Horwich, S. Lindstrom, Sonja I. Berndt, Jong Y. Park, Shannon K. McDonnell, Lin H-Y., Amit Joshi, Daniel Leongamornlert, Johanna Schleutker, Robert Huddart, Zhang H-W., Ruth Frikke-Schmidt, Melissa C. Southey, Amanda B. Spurdle, Jan Adolfsson, Michael Gaziano, David G. Cox, Elio Riboli, Erika M. Kwon, Jyotsna Batra, K. Govindasami, Amanda L. Hall, Karina Dalsgaard Sørensen, S. Benlloch, E. Saunders, Vanio Mitev, Paula Kujala, Chris Ogden, Peter Kraft, Anssi Auvinen, S. J. Chanock, Vincent Khoo, Kathleen Herkommer, Michael Borre, C. Slavov, Rosalind A. Eeles, Heiko Müller, Lisa A. Cannon-Albright, D J Schaid, David E. Neal, Doug Easton, Tammela Tlj., W. R. Diver, E J Sawyer, Martin Andreas Røder, Afshan Siddiq, Jianfeng Xu, Michelle Guy, Andreas Meyer, Joanne F. Aitken, Shintaro Narita, Michael J. Thun, Malgorzata Tymrakiewicz, James R. Marthick, Torben F. Ørntoft, Lynne T. O'Brien, Edward Giovannucci, R A Wilkinson, Fredrick R. Schumacher, Mariana C. Stern, Zsofia Kote-Jarai, Antje E. Rinckleb, Ahva Shahabi, Jarmo Virtamo, T A Sellers, Christiane Maier, C.R.J. Woodhouse, Pedro Vaz Pinto, Sue A. Ingles, Cezary Cybulski, Jenny L Donovan, Anna M. Ray, Henrik Grönberg, Markus Aly, Kenneth Muir, Suzanne K. Chambers, Tim Dudderidge, Danielle M. Karyadi, Judith A. Clements, Briony Patterson, Susan M. Gapstur, Manuel Luedeke, Demetrius Albanes, Federico Canzian, B. E. Henderson, Elaine A. Ostrander, Thilo Dörk, John L. Hopper, Fredrik Wiklund, Lu Y-J., Timothy J. Key, Meredith Yeager, Robert A. Stephenson, Liesel M. FitzGerald, Robert A. Gardiner, Ali Amin Al Olama, Manuel R. Teixeira, Rudolph Kaaks, David P. Dearnaley, Hermann Brenner, Kathleen A. Cooney, Maren Weischer, Jan Lubinski, Angela Cox, Aritaya Lophatonanon, Ruth C. Travis, Jürgen Serth, Suzanne Kolb, David J. Hunter, Stig E. Bojesen, Felicity Lose, Jonathan J. Morrison, Dominika Wokołorczyk, W. Vogel, W. Isaacs, Freddie C. Hamdy, Siqun L. Zheng, N. van As, A. Thompson, N. Mahmud, Dallas R. English, S. N. Thibodeau, Roman Corral, Janet L. Stanford, Colin Cooper, Norihiko Tsuchiya, Gerald L. Andriole, T. Wahlfors, D Campa, Craig C. Teerlink, Kimmo Taari, Tomonori Habuchi, Esther M. John, Chris Parker, Richard B. Hayes, Dietrich Rothenbacher, João Vasco Santos, Børge G. Nordestgaard, Radka Kaneva, Peter Klarskov, Christopher A. Haiman, Loic Le Marchand, Graham G. Giles

Publikováno v: Amin Al Olama, A, Kote-Jarai, Z, Schumacher, F R, Wiklund, F, Berndt, S I, Benlloch, S, Giles, G G, Severi, G, Neal, D E, Hamdy, F C, Donovan, J L, Hunter, D J, Henderson, B E, Thun, M J, Gaziano, M, Giovannucci, E L, Siddiq, A, Travis, R C, Cox, D G, Canzian, F, Riboli, E, Key, T J, Andriole, G, Albanes, D, Hayes, R B, Schleutker, J, Auvinen, A, Tammela, T L J, Weischer, M, Stanford, J L, Ostrander, E A, Cybulski, C, Lubinski, J, Thibodeau, S N, Schaid, D J, Sorensen, K D, Batra, J, Clements, J A, Chambers, S, Aitken, J, Gardiner, R A, Maier, C, Vogel, W, Dörk, T, Brenner, H, Habuchi, T, Ingles, S, John, E M, Orntoft, T F, Borre, M & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2013, ' A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease ', Human Molecular Genetics . https://doi.org/10.1093/hmg/dds425

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles

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http://ora.ox.ac.uk/objects/uuid:893cadad-9be1-489c-98c8-8d1839820f96