Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Tammaryn, Lashley"'
Autor:
Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M. Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Abstract Abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including Alzheimer’s disease (AD). In AD, this pathological change is reflec
Externí odkaz:
https://doaj.org/article/07ce566d50b649798807723349e5fe2c
Autor:
Przemysław R. Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R. Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C. Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M. Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally
Externí odkaz:
https://doaj.org/article/cd9a96562fae4bf787bc8b6e650f5603
Autor:
Huihui Luo, Emil K. Gustavsson, Hannah Macpherson, Natalia Dominik, Kristina Zhelcheska, Kylie Montgomery, Claire Anderson, Wai Yan Yau, Stephanie Efthymiou, Chris Turner, Michael DeTure, Dennis W. Dickson, Keith A. Josephs, Tamas Revesz, Tammaryn Lashley, Glenda Halliday, Dominic B. Rowe, Emily McCann, Ian Blair, Andrew J. Lees, Pentti J. Tienari, Anu Suomalainen, Laura Molina-Porcel, Gabor G. Kovacs, Ellen Gelpi, John Hardy, Matti J. Haltia, Arianna Tucci, Zane Jaunmuktane, Mina Ryten, Henry Houlden, Zhongbo Chen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-6 (2024)
Externí odkaz:
https://doaj.org/article/66ce109f71ec44af9981960c060d30a1
Autor:
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.
Externí odkaz:
https://doaj.org/article/b6483589f28142ef83c37fe4a6e6a7dc
Autor:
Christina E. Toomey, Wendy E. Heywood, James R. Evans, Joanne Lachica, Sarah N. Pressey, Sandrine C. Foti, Mesfer Al Shahrani, Karishma D’Sa, Iain P. Hargreaves, Simon Heales, Michael Orford, Claire Troakes, Johannes Attems, Ellen Gelpi, Miklos Palkovits, Tammaryn Lashley, Steve M. Gentleman, Tamas Revesz, Kevin Mills, Sonia Gandhi
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-25 (2022)
Abstract Background The molecular drivers of early sporadic Parkinson’s disease (PD) remain unclear, and the presence of widespread end stage pathology in late disease masks the distinction between primary or causal disease-specific events and late
Externí odkaz:
https://doaj.org/article/27e299286de341708a34798f4633c659
Autor:
Alexis Moscoso, Melissa C. Wren, Tammaryn Lashley, Erik Arstad, Melissa E. Murray, Nick C. Fox, Kerstin Sander, Michael Schöll
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/483bdb8b9982482da2936b48f6819fa4
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background The molecular heterogeneity of Alzheimer’s amyloid-β (Aβ) deposits extends well beyond the classic Aβ1-40/Aβ1-42 dichotomy, substantially expanded by multiple post-translational modifications that increase the proteome diver
Externí odkaz:
https://doaj.org/article/0df3c23e6c79457da2afc78f89b6eb98
Autor:
Megha Murthy, Patrizia Rizzu, Peter Heutink, Jonathan Mill, Tammaryn Lashley, Conceição Bettencourt
Publikováno v:
Cells, Vol 12, Iss 14, p 1922 (2023)
Frontotemporal lobar degeneration (FTLD) includes a heterogeneous group of disorders pathologically characterized by the degeneration of the frontal and temporal lobes. In addition to major genetic contributors of FTLD such as mutations in MAPT, GRN,
Externí odkaz:
https://doaj.org/article/2a1ad6d259af4646908283189de7ae35
Autor:
Jasmine Chebli, Maryam Rahmati, Tammaryn Lashley, Brigitta Edeman, Anders Oldfors, Henrik Zetterberg, Alexandra Abramsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated func
Externí odkaz:
https://doaj.org/article/24e291f60ef94c26ae05525f793703cf
Publikováno v:
Cells, Vol 12, Iss 12, p 1633 (2023)
Frontotemporal dementia (FTD) is the second most common form of young-onset (
Externí odkaz:
https://doaj.org/article/43607436d4a54425a619db60302c590c