Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro

Autor: Tamiris Borges da Silva, Erika Rendra, Christopher A.W. David, Karen Bieback, Michael J. Cross, Bettina Wilm, Neill J. Liptrott, Patricia Murray

Publikováno v: Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115624- (2023)

Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a role for secreted factors, such as MSC-derived extracellular vesicles (EVs). MSCs are known to

Externí odkaz: https://doaj.org/article/00ddb04672a54d6299c910861d8fcd0f

Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile

Autor: Mario Cruz, Vinicius Andrade-Oliveira, Ana Claudia Torrecilhas, Danilo Candido de Almeida, Regiane Aparecida Cavinato, Tamiris Borges da Silva, Cristiane Naffah de Souza Breda, Niels Olsen Saraiva Câmara, Alvaro Pacheco-Silva, Meire Ioshie Hiyane, Eliana L. Faquim-Mauro, Marcos Antonio Cenedeze, Flavia Franco da Cunha

Publikováno v: Cells, Vol 9, Iss 1059, p 1059 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cells
Volume 9
Issue 4

Mesenchymal stromal cells (MSCs) can generate immunological tolerance due to their regulatory activity in many immune cells. Extracellular vesicles (EVs) release is a pivotal mechanism by which MSCs exert their actions. In this study, we evaluate whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a378b986fe3340c3fdba20ab3e6aecd
https://www.mdpi.com/2073-4409/9/4/1059