Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial.

Autor: Patil, S. B.¹ (AUTHOR), Tamirat, M.² (AUTHOR), Khazhidinov, K.³ (AUTHOR), Ardizzoni, E.⁴ (AUTHOR), Atger, M.⁵ (AUTHOR), Austin, A.⁶ (AUTHOR), Baudin, E.⁷ (AUTHOR), Bekhit, M.⁵ (AUTHOR), Bektasov, S.⁸ (AUTHOR), Berikova, E.^3,9 (AUTHOR), Bonnet, M.¹⁰ (AUTHOR), Caboclo, R.⁵ (AUTHOR), Chaudhry, M.⁵ (AUTHOR), Chavan, V.¹¹ (AUTHOR), Cloez, S.⁵ (AUTHOR), Coit, J.¹² (AUTHOR), Coutisson, S.¹³ (AUTHOR), Dakenova, Z.¹⁴ (AUTHOR), De Jong, B. C.⁴ (AUTHOR), Delifer, C.⁵ (AUTHOR)

Publikováno v: Trials. 11/30/2023, Vol. 24 Issue 1, p1-14. 14p.

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Discovery of compounds inhibiting the ADP-ribosyltransferase activity of pertussis toxin

Autor: Ashok, Y. (Yashwanth), Miettinen, M. (Moona), de Oliveira, D. K. (Danilo Kimio Hirabae), Tamirat, M. Z. (Mahlet Z.), Näreoja, K. (Katja), Tiwari, A. (Avlokita), Hottiger, M. O. (Michael O.), Johnson, M. S. (Mark S.), Lehtiö, L. (Lari), Pulliainen, A. T. (Arto T.)

The targeted pathogen-selective approach to drug development holds promise to minimize collateral damage to the beneficial microbiome. The AB₅-topology pertussis toxin (PtxS1-S5) is a major virulence factor of Bordetella pertussis, the causative ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::506e40be02e8287d5785da1c6123639a
http://urn.fi/urn:nbn:fi-fe2020051435585

An unbiased in vitro screen for activating epidermal growth factor receptor mutations

Autor: Chakroborty, D. (Deepankar), Kurppa, K. J. (Kari J.), Paatero, I. (Ilkka), Ojala, V. K. (Veera K.), Koivu, M. (Marika), Tamirat, M. Z. (Mahlet Z.), Koivunen, J. P. (Jussi P.), Jänne, P. A. (Pasi A.), Johnson, M. S. (Mark S.), Elo, L. L. (Laura L.), Elenius, K. (Klaus)

Cancer tissues harbor thousands of mutations, and a given oncogene may be mutated at hundreds of sites, yet only a few of these mutations have been functionally tested. Here, we describe an unbiased platform for the functional characterization of tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::423369ba2e53263180ddb05b27e01fdd
http://urn.fi/urn:nbn:fi-fe202003097621

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