Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Tamir DI"'
Autor:
Tamir Dingjan, Anthony H. Futerman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Biological membranes consist of a lipid bilayer in which integral membrane proteins are embedded. Based on the compositional complexity of the lipid species found in membranes, and on their specific and selective interactions with membrane proteins,
Externí odkaz:
https://doaj.org/article/e49b5d3597bb40b7af78f852067fbdcc
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Hemophagocytic Lymphohistiocytosis (HLH) is a group of disorders culminating in systemic inflammation and multi-organ failure with high incidence of hepatic dysfunction. Overproduction of IFN-γ is the main immunopathological driver in this
Externí odkaz:
https://doaj.org/article/c2543beaef8b42f9b457cd7c5c1d0059
Autor:
Kapish Gupta, Jimmy P Xu, Tamir Diamond, Iris E M de Jong, Andrew Glass, Jessica Llewellyn, Neil D Theise, Orith Waisbourd-Zinman, Jeffrey D Winkler, Edward M Behrens, Clementina Mesaros, Rebecca G Wells
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301824 (2024)
Biliary atresia is a neonatal disease characterized by damage, inflammation, and fibrosis of the liver and bile ducts and by abnormal bile metabolism. It likely results from a prenatal environmental exposure that spares the mother and affects the fet
Externí odkaz:
https://doaj.org/article/74507efcbeca4a1daf62e83fff6e33fb
Autor:
Iris D. Zelnik, Beatriz Mestre, Jonathan J. Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J. Fleishman, Anthony H. Futerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-6 (2023)
Abstract Until now, membrane-protein stabilization has relied on iterations of mutations and screening. We now validate a one-step algorithm, mPROSS, for stabilizing membrane proteins directly from an AlphaFold2 model structure. Applied to the lipid-
Externí odkaz:
https://doaj.org/article/014e0396f55e4922b17b62df905dfa74
Autor:
Shani Blumenreich, Tamar Nehushtan, Or B. Barav, Jennifer T. Saville, Tamir Dingjan, John Hardy, Maria Fuller, Anthony H. Futerman
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract A number of genetic risk factors have been identified over the past decade for Parkinson’s Disease (PD), with variants in GBA prominent among them. GBA encodes the lysosomal enzyme that degrades the glycosphingolipid, glucosylceramide (Glc
Externí odkaz:
https://doaj.org/article/eef8903ef3da4d92af2541024a5a2e06
Autor:
Catherine A Chapin, Thomas M Burn, Tamir Diamond, Kathleen M Loomes, Estella M Alonso, Edward M Behrens
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286394 (2023)
A distinct phenotype of pediatric acute liver failure (PALF) has been identified, labeled activated T-cell hepatitis. These patients, previously included within the indeterminate group, have evidence of systemic immune activation and liver biopsy spe
Externí odkaz:
https://doaj.org/article/9d4b7210c09a457e93765223814102db
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 144-145 (2023)
OBJECTIVES/GOALS: Familial Hemophagocytic Lymphohistiocytosis (FHL) is a systemic inflammatory disease, causing acute liver failure (ALF). Elevated Interferon gamma (IFN-γ) results in increased hepatic transcription of the chemokines CXCL9 and CXCL1
Externí odkaz:
https://doaj.org/article/cc39c99c97fc440b97e01780e8499d81
Autor:
Tamir Diamond, Thomas N. Burn, Mailyn A. Nishiguchi, Danielle Minichino, Julie Chase, Niansheng Chu, Portia A. Kreiger, Edward M. Behrens
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway ameliorates FHL hepatitis, both in animal models and in humans with FHL. Hepatocytes are known t
Externí odkaz:
https://doaj.org/article/b02e6289a6744fb1838f28b7bc233c34
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Burkholderia ambifaria is an opportunistic respiratory pathogen belonging to the Burkholderia cepacia complex, a collection of species responsible for the rapidly fatal cepacia syndrome in cystic fibrosis patients. A fucose-binding lectin identified
Externí odkaz:
https://doaj.org/article/48d39b4434a44d81ad3a8ba415369689
Autor:
Schneider MJ; Department of Psychology, Princeton University., Rubin-McGregor J; Department of Psychology, Princeton University., Elder J; Department of Psychology, University of California, Riverside., Hughes BL; Department of Psychology, University of California, Riverside., Tamir DI; Department of Psychology, Princeton University.
Publikováno v:
Journal of experimental psychology. General [J Exp Psychol Gen] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.