Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Tamio Mizutani"'
Publikováno v:
YAKUGAKU ZASSHI. 120:307-310
While oxine-copper (OxCu) is generally used as an agricultural fungicide and induces a harmful effect on ecosystems, little information is available regarding a toxic effect of OxCu on mammals. In this article, we examined in vivo induction of toxici
Publikováno v:
Biological Trace Element Research. 76:75-84
Although it is assumed from in vitro experiments that the hydroxyl radical (*OH) may be responsible for chromium(VI) toxicity/carcinogenicity, no electron spin resonance (ESR) evidence for the generation of *OH in vivo has been reported. In this stud
Publikováno v:
Journal of Health Science. 46:75-80
It is assumed that oxidative stress due to reactive oxygen species (ROS) such as superoxide anion (·O2 -), hydrogen peroxide (H2O2) and hydroxyl radical (·OH) may result in oxidative damage to lipids and DNA. On the other hand, chromium(VI) compoun
Publikováno v:
Journal of Applied Toxicology. 19:193-198
Methimazole (MMI) (>0.1 mmol kg(-1), p.o.) given in combination with DL-buthionine sulphoximine (BSO) (3 mmol kg(-1), i.p., 1 h before MMI administration), an inhibitor of glutathione (GSH) synthesis, caused liver injury in mice. The injury was chara
Publikováno v:
Archives of Biochemistry and Biophysics. 361:207-214
6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione (TBE), a metabolite of 3-tert-butyl-4-hydroxyanisole, was converted to 6-tert-butyl-2, 3-epoxy-4(R)-hydroxy-5-cyclohexen-1-one ((4R)-TBEH) and 6-tert-butyl-2,3-epoxy-4(S)-hydroxy-5-cyclohexen-1-one ((4S)
Publikováno v:
Journal of Health Science. 45:329-332
Chromium(VI) compounds, potent carcinogens, are known to induce lipid peroxidation. However, it is not clear how Cr(VI) induces lipid peroxidation. It has been proposed that Cr intermediates such as Cr(IV) and Cr(V), possibly generated during the met
Autor:
Shosuke Kawanishi, Kohsuke Nishino, Tamio Mizutani, Sumiko Inoue, Saeko Oikawa, Shinji Oikawa
Publikováno v:
Biochemical Pharmacology. 56:361-370
DNA damage by metabolites of a food additive, butylated hydroxytoluene (BHT), was investigated as a potential mechanism of carcinogenicity. The mechanism of DNA damage by 2,6-di-tert-butyl-p-benzoquinone (BHT-quinone), 2,6-di-tert-butyl-4-hydroperoxy
Publikováno v:
Chemical Research in Toxicology. 6:174-179
In mice depleted of GSH by treatment with buthionine sulfoximine (BSO), thiabendazole (TBZ) causes renal injury characterized by an increase in serum urea nitrogen (SUN) concentration and by tubular necrosis. Previous studies have shown that TBZ requ
Publikováno v:
YAKUGAKU ZASSHI. 120:304-306
DL-Lactic acid and its salts are added to food as acidulants, pH control agents, leavening agents, nutrient supplements and seasonings. However, the basic data concerning the safety and toxicity of these compounds are insufficient. In this article, w
Publikováno v:
Journal of Health Science. 46:56-58
Natural colorants are widely used as additives to various foods. However, the basic data concerning the safety of these colorants are insufficient. Seven natural food colorants were assessed for their hepato- and nephrotoxicity in mice depleted of gl