Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Tamio Fujiwara"'
Autor:
Tamio FUJIWARA, Hiroshi OHUE
Publikováno v:
Journal of Fluid Science and Technology, Vol 3, Iss 5, Pp 645-654 (2008)
In order to measure unsteady flow rate of the order of less than 1μl/sec, a new flowmeter consisting of a capillary and a pressure gauge has been developed. When a target flow passes through the capillary, the measured pressure loss in the capillary
Externí odkaz:
https://doaj.org/article/f2bff4599692434493e7a5f29b204f5e
Publikováno v:
Journal of Fluid Science and Technology, Vol 2, Iss 2, Pp 389-399 (2007)
To reduce the molecular diffusion mixing time in a microreactor, the efficacy of a layered flow pattern generated by an alternate pumping system has been reported. In this paper, we propose an asterisk-shaped channel, which has two inlets and two div
Externí odkaz:
https://doaj.org/article/86aa5e03041d4cd9a13f7edf2a1c8b17
Publikováno v:
Journal of Fluid Science and Technology, Vol 9, Iss 3, Pp JFST0033-JFST0033 (2014)
Over the last decade, synthetic jets suitable for micro-machinery have received attention for their potential to replace continuous jets. The development of synthetic jet actuators with, for example, a diaphragm, a piston, a piezoelectric element, or
Externí odkaz:
https://doaj.org/article/6dfd2e50bed249ce93f4e577d46a9343
Autor:
Takahiro Seki, Mark Underwood, Shinobu Kawauchi-Miki, Masanori Kobayashi, Shigeru Miki, Eugene L. Stewart, Tadashi Miyamoto, Tamio Fujiwara, Akemi Suyama-Kagitani, Akihiko Sato, Tomokazu Yoshinaga
Publikováno v:
Antiviral Research. 152:1-9
Cabotegravir (CAB, S/GSK1265744) is an investigational second-generation integrase strand transfer inhibitor (INSTI) with a chemical structure similar to dolutegravir. CAB is under development as a long-acting injectable formulation for treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5fca52770709fcb2a488872dae3903
https://doi.org/10.1016/j.antiviral.2018.01.013
https://doi.org/10.1016/j.antiviral.2018.01.013
Publikováno v:
Antimicrobial agents and chemotherapy. 63(3)
A major concern when using two-drug anti-HIV regimens is the risk of viral resistance. However, no techniques to evaluate the barrier to resistance of two-drug combinations in vitro have been reported. We evaluated the emergence of drug-resistant mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30901d12fddf987c15b36643af7d5f91
https://pubmed.ncbi.nlm.nih.gov/30602514
https://pubmed.ncbi.nlm.nih.gov/30602514
Autor:
Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, Jason G. Weatherhead, Toshiyuki Akiyama, Teruhiko Taishi, Yoshiyuki Taoda, Minako Mikamiyama-Iwata, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Norihiko Tanimoto, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Edward P. Garvey, Tamio Fujiwara
Publikováno v:
Journal of Medicinal Chemistry. 56:1124-1135
This work is a continuation of our initial discovery of a potent monocyclic carbamoyl pyridone human immunodeficiency virus type-1 (HIV-1) integrase inhibitor that displayed favorable antiviral and pharmacokinetic properties. We report herein a serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1167fb02558e33f61b588c3a9fb8ae3c
https://doi.org/10.1021/jm301550c
https://doi.org/10.1021/jm301550c
Autor:
Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, Eric E. Boros, James B. Thompson, Cecilia S. Koble, Edward P. Garvey, Scott A. Foster, Jerry L. Jeffrey, Tamio Fujiwara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:422-425
Substituent effects of a series of N1 protio and methyl naphthyridinone HIV-1 integrase strand-transfer inhibitors has been explored. The effects of combinations of the N1 substituent and C3 amide groups was extensively studied to compare enzyme inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817677cd6ad6a53814c550916eb03503
https://doi.org/10.1016/j.bmcl.2012.11.071
https://doi.org/10.1016/j.bmcl.2012.11.071
Publikováno v:
Journal of Visualization. 15:197-205
During the development of micromixers and microreactors, it is important to assess the concentration field and mixing status in their microchannels. Therefore, this study establishes a visualization method for evaluating the concentration field using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e204bb545c636172acec25d9d9d7c003
https://doi.org/10.1007/s12650-012-0126-1
https://doi.org/10.1007/s12650-012-0126-1
Autor:
Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, Eric E. Boros, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry L. Jeffrey, Wayne H. Miller, Noriyuki Kurose, Kenichi Matsumura, Tamio Fujiwara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6461-6464
A series of naphthyridinone HIV-1 integrase strand-transfer inhibitors have been designed based on a psdeudo-C2 symmetry element present in the two-metal chelation pharmacophore. A combination of two distinct inhibitor binding modes resulted in poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543859790f45db50300fc75d2aaf2ab7
https://doi.org/10.1016/j.bmcl.2011.08.082
https://doi.org/10.1016/j.bmcl.2011.08.082
Autor:
Tamio Fujiwara, Ivy Song, Julie Borland, Stephen C. Piscitelli, Yu Lou, Sherene Min, Shuguang Chen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:254-258
S/GSK1349572 is a novel integrase inhibitor with potent in vitro anti-HIV activity, an in vitro resistance profile different from those of other integrase inhibitors, and favorable preclinical safety and pharmacokinetics (PK). Randomized, double-blin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb81cf8b52b4a03bda8b3a557ddd4025
https://doi.org/10.1128/aac.00842-09
https://doi.org/10.1128/aac.00842-09