Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tamily A Weissman"'
Autor:
Vivek K Unni, Tamily A Weissman, Edward Rockenstein, Eliezer Masliah, Pamela J McLean, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10589 (2010)
Regulation of alpha-synuclein levels within cells is thought to play a critical role in Parkinson's Disease (PD) pathogenesis and in other related synucleinopathies. These processes have been studied primarily in reduced preparations, including cell
Externí odkaz:
https://doaj.org/article/8fc8346da91c46eebaaa43ecaae1abb2
Autor:
Sylvia Nkombo Nkoula, Helen Ippolito, Zoe T. Cook, Isaac S. Boardman, Zachary J. C. Tobias, Tamily A. Weissman, Joy Pajarla, Nicole L. Brockway
Publikováno v:
Molecular Biology of the Cell
Fluorescent proteins are a powerful experimental tool, allowing the visualization of gene expression and cellular behaviors in a variety of systems. Multicolor combinations of fluorescent proteins, such as Brainbow, have expanded the range of possibl
Autor:
Leah J. Weston, Teresa L. Stackhouse, Greta Glover, Saheli Pizano, Mehtab K. Sal, Zachary J. C. Tobias, Baergen I. Schultz, Vivek K. Unni, Valerie R. Osterberg, Zoe T. Cook, Tamily A. Weissman, Nicole L. Brockway
Publikováno v:
Neurobiology of Disease, Vol 152, Iss, Pp 105291-(2021)
Abnormal aggregation of the α-synuclein protein is a key molecular feature of Parkinson's disease and other neurodegenerative diseases. The precise mechanisms that trigger α-synuclein aggregation are unclear, and it is not known what role aggregati
Autor:
Sydney E. Dent, Dennisha P. King, Valerie R. Osterberg, Eleanor K. Adams, Marilyn R. Mackiewicz, Tamily A. Weissman, Vivek K. Unni
Publikováno v:
The Journal of Biological Chemistry
Alpha-synuclein (aSyn) is a vertebrate protein, normally found within the presynaptic nerve terminal and nucleus, which is known to form somatic and neuritic aggregates in certain neurodegenerative diseases. Disease-associated aggregates of aSyn are
Publikováno v:
Journal of Visualized Experiments.
Development of the vertebrate nervous system requires a precise coordination of complex cellular behaviors and interactions. The use of high resolution in vivo imaging techniques can provide a clear window into these processes in the living organism.
Autor:
Amanda K. McCullough, Sydney Weber Boutros, Tamily A. Weissman, Randall L. Woltjer, Colin M. Wakeham, Sydney E. Dent, Valerie R. Osterberg, Jacob Raber, Esteban Luna, Nichole Owen, Leah J. Weston, Kelvin C. Luk, Vivek K. Unni, Allison J. Schaser, Teresa L. Stackhouse
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its function in the nucleus is not well understood. We demonstrate that alph
Autor:
Maritte J. O'Gallagher, Nicole L. Brockway, Zoe T. Cook, Kristine M. Carey, Tamily A. Weissman, Mako Gedi, Margaret R. Metz, Zachary J. C. Tobias, Vivek K. Unni, Y. Albert Pan
Publikováno v:
Developmental biology. 453(2)
The global mechanisms that regulate and potentially coordinate cell proliferation & death in developing neural regions are not well understood. In particular, it is not clear how or whether clonal relationships between neural progenitor cells and the
Autor:
Kateri J. Spinelli, Vivek K. Unni, Sydney Weber Boutros, Jacob Raber, Tamily A. Weissman, Elizabeth P. Rose, Valerie R. Osterberg, Leah J. Weston, Kelvin C. Luk, Teresa L. Stackhouse
Publikováno v:
The Journal of Biological Chemistry
Phosphorylation of alpha-synuclein at serine-129 is an important marker of pathologically relevant, aggregated forms of the protein in several important human diseases, including Parkinson's disease, Dementia with Lewy bodies, and Multiple system atr
Publikováno v:
Developmental Neurobiology. 75:1174-1188
The cells that comprise the cerebellum perform a complex integration of neural inputs to influence motor control and coordination. The functioning of this circuit depends upon Purkinje cells and other cerebellar neurons forming in the precise place a
Publikováno v:
Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience. 13(3)
The lateral line sensory system in fish detects movements in the water and allows fish to respond to predators, prey, and other stimuli. As the lateral line forms in the first two days of zebrafish development, axons extend caudally along the lateral