Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Tamil S. Anthonymuthu"'
Autor:
Ghaith M. Hamza, Eric Miele, Don M. Wojchowski, Paul Toran, Camilla R. Worsfold, Tamil S. Anthonymuthu, Vladislav B. Bergo, Andrew X. Zhang, Jeffrey C. Silva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10060 (2023)
For targeted protein panels, the ability to specifically assay post-translational modifications (PTMs) in a quantitative, sensitive, and straightforward manner would substantially advance biological and pharmacological studies. The present study high
Externí odkaz:
https://doaj.org/article/2e86632b18a9450db116267550abfbd6
Autor:
Andrew M. Lamade, Limin Wu, Haider H. Dar, Heather L. Mentrup, Indira H. Shrivastava, Michael W. Epperly, Claudette M. St Croix, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Qin Yang, Aleksandr A. Kapralov, Zhentai Huang, Gaowei Mao, Andrew A. Amoscato, Zachary E. Hier, Margarita A. Artyukhova, Galina Shurin, Joel C. Rosenbaum, Peter J. Gough, John Bertin, Andrew P. VanDemark, Simon C. Watkins, Kevin P. Mollen, Ivet Bahar, Joel S. Greenberger, Valerian E. Kagan, Michael J. Whalen, Hülya Bayır
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102232- (2022)
Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3 kinases. F
Externí odkaz:
https://doaj.org/article/f183853d46e94325b02ce4c0422c4965
Autor:
Haider H. Dar, Michael W. Epperly, Vladimir A. Tyurin, Andrew A. Amoscato, Tamil S. Anthonymuthu, Austin B. Souryavong, Alexander A. Kapralov, Galina V. Shurin, Svetlana N. Samovich, Claudette M. St. Croix, Simon C. Watkins, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Yulia Y. Tyurina
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Total body irradiation (TBI) targets sensitive bone marrow hematopoietic cells and gut epithelial cells, causing their death and inducing a state of immunodeficiency combined with intestinal dysbiosis and nonproductive immune responses. We found enha
Externí odkaz:
https://doaj.org/article/064649aa63e64d92892a0366bc434be8
Autor:
Haider H. Dar, Tamil S. Anthonymuthu, Liubov A. Ponomareva, Austin B. Souryavong, Galina V. Shurin, Alexandr O. Kapralov, Vladimir A. Tyurin, Janet S. Lee, Rama K. Mallampalli, Sally E. Wenzel, Hülya Bayir, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102045- (2021)
Ferroptosis is a redox-driven type of regulated cell death program arising from maladaptation of three metabolic pathways: glutathione homeostasis, iron handling and lipid peroxidation. Though GSH/Gpx4 is the predominant system detoxifying phospholip
Externí odkaz:
https://doaj.org/article/e3f67850337e451888b65ee03ea99b6a
Autor:
Valerian E. Kagan, Yulia Y. Tyurina, Irina I. Vlasova, Alexander A. Kapralov, Andrew A. Amoscato, Tamil S. Anthonymuthu, Vladimir A. Tyurin, Indira H. Shrivastava, Fatma B. Cinemre, Andrew Lamade, Michael W. Epperly, Joel S. Greenberger, Donald H. Beezhold, Rama K. Mallampalli, Apurva K. Srivastava, Hulya Bayir, Anna A. Shvedova
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
A huge diversification of phospholipids, forming the aqueous interfaces of all biomembranes, cannot be accommodated within a simple concept of their role as membrane building blocks. Indeed, a number of signaling functions of (phospho)lipid molecules
Externí odkaz:
https://doaj.org/article/a18efc8008b949158d6d416288395fb3
Autor:
Tamil S. Anthonymuthu, Yulia Y. Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Vladimir A. Tyurin, Fatma B. Cinemre, Haider H. Dar, Andrew P. VanDemark, Theodore R. Holman, Yoel Sadovsky, Brent R. Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101744- (2021)
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic r
Externí odkaz:
https://doaj.org/article/2be5ba9f39624a43ae53e3556263b20b
Autor:
Karolina Mikulska-Ruminska, Tamil S. Anthonymuthu, Anastasia Levkina, Indira H. Shrivastava, Alexandr A. Kapralov, Hülya Bayır, Valerian E. Kagan, Ivet Bahar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5253 (2021)
We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO● suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LO
Externí odkaz:
https://doaj.org/article/326df8e3eb9a4a9c9eaa80be0a2d369b
Autor:
Andrew M. Lamade, Tamil S. Anthonymuthu, Elizabeth M. Kenny, Hitesh Gidwani, Nicholas M. Krehel, Andrew A. Amoscato, Adam C. Straub, Valerian E. Kagan, Cameron Dezfulian, Hülya Bayır
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 17-17 (2018)
OBJECTIVES/SPECIFIC AIMS: Neurological injury remains as the main limiting factor for overall recovery after cardiac arrest (CA). Currently available indicators of neurological injury are inadequate for early prognostication after return of spontaneo
Externí odkaz:
https://doaj.org/article/18461b9ed5e34375af3e4a57de3ab794
Autor:
Silva, Ghaith M. Hamza, Eric Miele, Don M. Wojchowski, Paul Toran, Camilla R. Worsfold, Tamil S. Anthonymuthu, Vladislav B. Bergo, Andrew X. Zhang, Jeffrey C.
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10060
For targeted protein panels, the ability to specifically assay post-translational modifications (PTMs) in a quantitative, sensitive, and straightforward manner would substantially advance biological and pharmacological studies. The present study high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b99762ccf484abc2049aaeb77467f85e
Autor:
Hua Tian, Rong-Rong He, Wan Yang Sun, Hülya Bayır, Nicholas Winograd, Valerian E. Kagan, Andrew A. Amoscato, Louis J. Sparvero, Tamil S. Anthonymuthu
Publikováno v:
Analytical Chemistry. 93:8143-8151
The temporo-spatial organization of different cells in the tumor microenvironment (TME) is the key to understanding their complex communication networks and the immune landscape that exists within compromised tissues. Multi-omics profiling of single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dee9aac556d0666bb14e27bd949ff64
https://doi.org/10.1021/acs.analchem.0c05311
https://doi.org/10.1021/acs.analchem.0c05311