Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Tamie Nakajima"'
Autor:
Sumitaka Kobayashi, Fumihiro Sata, Houman Goudarzi, Atsuko Araki, Chihiro Miyashita, Seiko Sasaki, Emiko Okada, Yusuke Iwasaki, Tamie Nakajima, Reiko Kishi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the pre
Externí odkaz:
https://doaj.org/article/5c384c0018014967929ebed40a2459b4
Autor:
Tomomi Asano, Kentaro Taki, Kazuya Kitamori, Hisao Naito, Tamie Nakajima, Hitoshi Tsuchihashi, Akira Ishii, Kei Zaitsu
Publikováno v:
ACS Omega, Vol 6, Iss 12, Pp 8588-8597 (2021)
Externí odkaz:
https://doaj.org/article/cee3de4289224cde8d7acc801455e869
Autor:
Hisao Naito, Yuki Yoshikawa-Bando, Yuan Yuan, Sayuki Hashimoto, Kazuya Kitamori, Hiroshi Yatsuya, Tamie Nakajima
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory–Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-
Externí odkaz:
https://doaj.org/article/f91c6d4f598d4f9c8d009ffc735a237d
Publikováno v:
Environmental Health and Preventive Medicine, Vol 24, Iss 1, Pp 1-9 (2019)
Abstract The plasticizer di(2-ethylhexyl) phthalate (DEHP) has been widely used in the manufacture of polyvinyl chloride-containing products such as medical and consumer goods. Humans can easily be exposed to it because DEHP is ubiquitous in the envi
Externí odkaz:
https://doaj.org/article/7f7e02bd2090489c80e944e6cc88d8c5
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243846 (2020)
Hypertension is an important risk factor for nonalcoholic steatohepatitis. We have previously demonstrated that hypertensive rats fed a high fat and cholesterol (HFC) diet incurred a more severe hepatic inflammatory response and fibrosis. Here we inv
Externí odkaz:
https://doaj.org/article/3c01f45918f34266a044aa1ebf1f8afe
Autor:
Husna Yetti, Hisao Naito, Yuan Yuan, Xiaofang Jia, Yumi Hayashi, Hazuki Tamada, Kazuya Kitamori, Katsumi Ikeda, Yukio Yamori, Tamie Nakajima
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192863 (2018)
During middle age, women are less susceptible to nonalcoholic steatohepatitis (NASH) than men. Thus, we investigated the underlying molecular mechanisms behind these sexual differences using an established rat model of NASH. Mature female and male st
Externí odkaz:
https://doaj.org/article/a0befe3e039a47328e0038cd476f6edf
Autor:
Hazuki Tamada, Hisao Naito, Kazuya Kitamori, Yumi Hayashi, Nozomi Yamagishi, Masashi Kato, Tamie Nakajima
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145939 (2016)
Nonalcoholic steatohepatitis is related to lifestyle, particularly to dietary habits. We developed diet-induced fibrotic steatohepatitis model stroke-prone spontaneously hypertensive 5/Dmcr (SHRSP5/Dmcr) rats showing steatosis, hepatic inflammation,
Externí odkaz:
https://doaj.org/article/eca2483b8e7943c1b523e53d0e7af558
Autor:
Atsuko Araki, Takahiko Mitsui, Chihiro Miyashita, Tamie Nakajima, Hisao Naito, Sachiko Ito, Seiko Sasaki, Kazutoshi Cho, Tamiko Ikeno, Katsuya Nonomura, Reiko Kishi
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109039 (2014)
Prenatal di(2-ethylhexyl) phthalate (DEHP) exposure can produce reproductive toxicity in animal models. Only limited data exist from human studies on maternal DEHP exposure and its effects on infants. We aimed to examine the associations between DEHP
Externí odkaz:
https://doaj.org/article/f46fa17783f74f71857a7d2c008598a5
Autor:
Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima
Publikováno v:
PPAR Research, Vol 2012 (2012)
Dibutylphthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), and di(2-ethylhexyl)adipate (DEHA) are used as plasticizers. Their metabolites activate peroxisome proliferator-activated receptor (PPAR) α, which may be related to their toxicities. However,
Externí odkaz:
https://doaj.org/article/7aeffa1c550e40afaff19677c5bc24a2
Autor:
Yuki Ito, Tamie Nakajima
Publikováno v:
PPAR Research, Vol 2008 (2008)
Di(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer and a potentially nongenotoxic carcinogen. Its mechanism had been earlier proposed based on peroxisome proliferator-activated receptor α (PPARα) because metabolites of DEHP are agonists.
Externí odkaz:
https://doaj.org/article/36eb5e19327f48c29431f350084d2b04