Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

Autor: Chenlu Zhang, Zehan Hu, Abdul G Lone, Methinee Artami, Marshall Edwards, Christos C Zouboulis, Maggie Stein, Tamia A Harris-Tryon

Publikováno v: eLife, Vol 11 (2022)

Human skin functions as a physical barrier, preventing the entry of foreign pathogens while also accommodating a myriad of commensal microorganisms. A key contributor to the skin landscape is the sebaceous gland. Mice devoid of sebocytes are prone to

Externí odkaz: https://doaj.org/article/2948ac5847f24f4aa5def328cba952d0

Novel mechanisms of microbial crosstalk with skin innate immunity

Autor: Tamia A. Harris-Tryon, Mahendran Chinnappan

Publikováno v: Experimental Dermatology. 30:1484-1495

Skin is an organ with a dynamic ecosystem that harbours pathogenic and commensal microbes, which constantly communicate amongst each other and with the host immune system. Evolutionarily, skin and its microbiota have evolved to remain in homeostasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54fc7eb7a31087bc942c213ccb38312
https://doi.org/10.1111/exd.14429

Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

Autor: Tamia A. Harris-Tryon, Chenlu Zhang, Maggie Stein, Marshall Edwards, Zehan Hu, Abdul Lone, Methinee Artami

Publikováno v: eLife. 11

Human skin functions as a physical barrier, preventing the entry of foreign pathogens while also accommodating a myriad of commensal microorganisms. A key contributor to the skin landscape is the sebaceous gland. Mice devoid of sebocytes are prone to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350d97d5dd23b5baaa406946b0514cda
https://doi.org/10.7554/elife.76729

List of contributors

Autor: Rina Aharoni, Zulfiqar Ahmad, Suhail Akhtar, N. D. Prasad Atmuri, Carmen Avendaño, Ivneet Banga, Shai Bel, Łukasz Berlicki, Yair Blumberg, Carine Bourguet, Marlon Henrique Cardoso, Samraggi Choudhury, Sitan Diarra, Marvin N. Driessen, Michael K. Dunn, Vandon T. Duong, Offir Ertracht, Emer S. Ferro, Octavio Luiz Franco, Tatiana Galochkina, Sonu Gandhi, Shikun Ge, Jean-Christophe Gelly, Mayara C.F. Gewehr, Rujuta Ghorpade, Eric R. Gross, Wessal Hanout, Tamia A. Harris, Adrienne Joseph, Srinivasaraghavan Kannan, Abidemi Paul Kappo, Krishna Kumar, Maushmi S. Kumar, Dilraj Lama, Jolene L. Lau, Jianguo Li, Adi Litmanovich, Jamie Liu, William D. Lubell, Lloyd Mabonga, Subhasis Mahari, Priscilla Masamba, J. Carlos Menéndez, Gassan Moady, Satheesh Kumar Nanjappan, Ami Navon, Ines Neundorf, Meital Nuriel-Ohayon, Dmitriy Orlov, David Paul, Ron Piran, William Farias Porto, Nir Qvit, Samuel J.S. Rubin, Mussa Saad, Deepshikha Shahdeo, Olga Shamova, Kathleen M. Sicinski, Abhishek Singh, Worood Sirhan, Shruti Surendran, Simon Surprenant, Yaw Sing Tan, Mukesh Thakur, Ekaterina Umnyakova, Özge Ünsal, Chandra S Verma, Nana-Maria Wagner, Zhipeng A. Wang, Bryan J. Xie, Long Xu, Vanessa O. Zambelli, Xiaoying Zhang, Ji-Shen Zheng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cd1766f7274d84b4d2ea94b9168ec00
https://doi.org/10.1016/b978-0-12-820141-1.00034-0

Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection

Autor: Mihir Pendse, Daniel C. Propheter, Tamia A. Harris-Tryon, Kelly A. Ruhn, Zehan Hu, Chenlu Zhang, Lora V. Hooper, Yuhao Wang, Prithvi Raj, Bo Zhang, Tiffany A. Reese, Zheng Kuang, Cassie L. Behrendt, Luis Sifuentes-Dominguez, Christina Zarek, Brian Hassell

Publikováno v: Science. 374

AMPlifying type 2 immunity Antimicrobial proteins (AMPs) are a frontline defense against pathogenic microorganisms at mucosal surfaces. These cationic molecules inactivate their targets primarily by disrupting cell walls and membranes. Hu et al . fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074a5c0d23aedcafdbd645f69027c6c8
https://doi.org/10.1126/science.abe6723