Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tami J. Kingsbury"'
Autor:
Sang W. Hyun, Chiguang Feng, Anguo Liu, Erik P. Lillehoj, Rossana Trotta, Tami J. Kingsbury, Antonino Passaniti, Katerina N. Lugkey, Sitara Chauhan, John F. Cipollo, Irina G. Luzina, Sergei P. Atamas, Alan S. Cross, Simeon E. Goldblum
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-23 (2022)
Abstract To gain insight into sialic acid biology and sialidase/neuraminidase (NEU) expression in mature human neutrophil (PMN)s, we studied NEU activity and expression in PMNs and the HL60 promyelocytic leukemic cell line, and changes that might occ
Externí odkaz:
https://doaj.org/article/289ac30cc0a342a584ab79a26dfc59e5
Autor:
Anna J. Dellomo, Rachel Abbotts, Christian L. Eberly, Mariusz Karbowski, Maria R. Baer, Tami J. Kingsbury, Feyruz V. Rassool
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101283- (2022)
Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) con
Externí odkaz:
https://doaj.org/article/1a37956d049b40a797eb0d03b6d03d1b
Autor:
Robert A. Brown, Antanina Voit, Manasa P. Srikanth, Julia A. Thayer, Tami J. Kingsbury, Marlene A. Jacobson, Marta M. Lipinski, Ricardo A. Feldman, Ola Awad
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive. GBA1 mutations are also the most frequent g
Externí odkaz:
https://doaj.org/article/071ad8f2001a470988d9369dd1d74923
Publikováno v:
BioTechniques, Vol 54, Iss 2, Pp 77-86 (2013)
MicroRNAs (miRs) regulate cellular processes by modulating gene expression. Although transcriptomic studies have identified numerous miRs differentially expressed in diseased versus normal cells, expression analysis alone cannot distinguish miRs driv
Externí odkaz:
https://doaj.org/article/3ffe6b7aa8b442dba6e746cd6842dc1d
Autor:
Aksinija A, Kogan, Michael J, Topper, Anna J, Dellomo, Lora, Stojanovic, Lena J, McLaughlin, T Michael, Creed, Christian L, Eberly, Tami J, Kingsbury, Maria R, Baer, Michael D, Kessler, Stephen B, Baylin, Feyruz V, Rassool
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(27)
DNA methyltransferase inhibitors (DNMTis) reexpress hypermethylated genes in cancers and leukemias and also activate endogenous retroviruses (ERVs), leading to interferon (IFN) signaling, in a process known as viral mimicry. In the present study we s
Autor:
Christian Eberly, Feyruz V. Rassool, Tami J. Kingsbury, Rachel Abbotts, Maria R. Baer, Anna J. Dellomo, Mariusz Karbowski
Publikováno v:
Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101283-(2022)
Translational Oncology, Vol 15, Iss 1, Pp 101283-(2022)
Highlights • PARP1-dependent PARylation post-translationally modifies and regulates STAT5. • Catalytic PARP inhibition reduces STAT5 stability. • PARP1 loss results in reduced STAT5 signaling and activation of downstream targets. • STAT5-acti
Autor:
Sang W. Hyun, Chiguang Feng, Anguo Liu, Erik P. Lillehoj, Rossana Trotta, Tami J. Kingsbury, Antonino Passaniti, Katerina N. Lugkey, Sitara Chauhan, John F. Cipollo, Irina G. Luzina, Sergei P. Atamas, Alan S. Cross, Simeon E. Goldblum
Publikováno v:
Scientific reports. 12(1)
To gain insight into sialic acid biology and sialidase/neuraminidase (NEU) expression in mature human neutrophil (PMN)s, we studied NEU activity and expression in PMNs and the HL60 promyelocytic leukemic cell line, and changes that might occur in PMN
Autor:
Ashkan Emadi, Tami J. Kingsbury, Samantha McCullough, Søren M. Bentzen, Michelle A. Rudek, Jeffrey W. Tyner, MinJung Kim, Bryan T. Mott, Jennifer M. Fox, Rena G. Lapidus, Blake S. Moses, Curt I. Civin
Publikováno v:
Blood Adv
Artemisinins are active against human leukemia cell lines and have low clinical toxicity in worldwide use as antimalarials. Because multiagent combination regimens are necessary to cure fully evolved leukemias, we sought to leverage our previous find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe546e2ae9a535af0e4d4ef178c45a
https://europepmc.org/articles/PMC7876886/
https://europepmc.org/articles/PMC7876886/
Autor:
Kavita Bhalla, Rena G. Lapidus, Karen F. Underwood, Binny Bhandary, Brian M. Polster, Arielle Hamburg, Ruching Hisa, Kayla Reagan, Dirk Mayer, Shambhu Bhat, Tami J. Kingsbury, Aditya Jhajharia, Maninder Singh, Nahid M Nanaji, Heather Huot Creasy, Ronald B. Gartenhaus, Carrie McCracken, Sausan M. Jaber
Publikováno v:
Scientific Reports
Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell lymphoma (DLBCL) significantly induce mitochondrial deacetylase sirtuin-3 (SIRT3) activity, d
Autor:
Rajkumar Baldeosingh, Curt I. Civin, Akhilesh Pandey, T. Michael Creed, Nancy Fossett, Christian Eberly, Caroline S. Schlee, Jevon Cutler, Tami J. Kingsbury, MinJung Kim
Publikováno v:
Development
The GATA and PAX-SIX-EYA-DACH (PSEDN) transcriptional networks are essential for proper development across taxa. Here we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro. Using Drosophila genetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b9ca9a07bc4799ae871a8cfbf9706f
https://europepmc.org/articles/PMC6983716/
https://europepmc.org/articles/PMC6983716/