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Akademický článek

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death

Autor: Peter I. Darroch, Arie Dagan, Tami Granot, Xingxuan He, Shimon Gatt, Edward H. Schuchman

Publikováno v: Journal of Lipid Research, Vol 46, Iss 11, Pp 2315-2324 (2005)

We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled sph

Externí odkaz: https://doaj.org/article/0e3c9696d4ce48b6a8816460f180b6ee

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Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study

Autor: Tzufit Cuker, Dan M. Livovsky, Rivka Farkash, Aviya Hoyda, Tami Granot, Ariella Bar-Gil Shitrit, Sorina Grisaru-Granovsky, Adi Lahat, Irit Avni-Biron, Eran Goldin, Ami Ben Ya'acov

Publikováno v: The American journal of gastroenterology. 114(7)

Despite encouraging data gathered in inflammatory bowel diseases (IBD) patients, Vedolizumabs' (VDZ) safety profile in pregnancy is not established.Data of 330 consecutive pregnancies with IBD was prospectively collected.Women with IBD were treated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f675e30a94b34b3c92497ba0079a73
https://pubmed.ncbi.nlm.nih.gov/30920987

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