Výsledky vyhledávání - "Tamer S. Kaoud"

Akademický článek

Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection

Publikováno v: iScience, Vol 26, Iss 10, Pp 107817- (2023)

Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi

Externí odkaz: https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d

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Akademický článek

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult to target pharmacologically. Here, the authors identify a small molecule inhibitor that binds covalently to the D-recruitment site of ERK and induces cell de

Externí odkaz: https://doaj.org/article/a5398760f41b41118e32f8afccdebe49

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Akademický článek

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

Autor: Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips, Jonathan M. Kurie

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ect

Externí odkaz: https://doaj.org/article/66b3577e6b604e7983c92825500bf879

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Akademický článek

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to also include support from the National Institutes of Health grant T32GM008280 to Sa

Externí odkaz: https://doaj.org/article/64b600169e7a4afab4f46b9a90ad3e75

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Biomechanical Dependence of SARS-CoV-2 Infections

Autor: Alexandra Paul, Sachin Kumar, Tamer S. Kaoud, Madison Pickett, Amanda L. Bohanon, Janet Zoldan, Kevin N. Dalby, Sapun H. Parekh

Publikováno v: ACS Applied Bio Materials. 5:2307-2315

Older people have been disproportionately vulnerable to the current SARS-CoV-2 pandemic, with an increased risk of severe complications and death compared to other age groups. A mix of underlying factors has been speculated to give rise to this diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a0c5305aaeddc125f53c9fb2572c42
https://doi.org/10.1021/acsabm.2c00143

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Short Arrestin-3-Derived Peptides Activate JNK3 in Cells

Autor: Nicole A. Perry-Hauser, Tamer S. Kaoud, Henriette Stoy, Xuanzhi Zhan, Qiuyan Chen, Kevin N. Dalby, Tina M. Iverson, Vsevolod V. Gurevich, Eugenia V. Gurevich

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8679

Arrestins were first discovered as suppressors of G protein-mediated signaling by G protein-coupled receptors. It was later demonstrated that arrestins also initiate several signaling branches, including mitogen-activated protein kinase cascades. Arr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b18d4458916650f1f5907916ddcd87

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Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications

Autor: Christian P. Whitman, Bert-Jan Baas, Tamer S. Kaoud, Patricia C. Babbitt, Kaci Erwin, R. Yvette Moreno, Jake LeVieux, Marieke de Ruijter, Yan Jessie Zhang, William H. Johnson, Emily B. Lancaster, Brenda P. Medellin

Publikováno v: Biochemistry

The tautomerase superfamily (TSF) is a collection of enzymes and proteins that share a simple β-α-β structural scaffold. Most members are constructed from a single-core β-α-β motif or two consecutively fused β-α-β motifs in which the N-termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2909817e4454a4b3cff587e222f09d
https://doi.org/10.1021/acs.biochem.1c00220

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Multiplexing the Quantitation of MAP Kinase Activities Using Differential Sensing

Autor: Lingyu Zeng, Tamer S. Kaoud, Diana Zamora-Olivares, Amanda L. Bohanon, Yiru Li, Jacey R. Pridgen, Yakndara E. Ekpo, Deborah L. Zhuang, Jessica R. Nye, Mitchell Telles, Michelle Winkler, Sebastian Rivera, Federico Marini, Kevin N. Dalby, Eric V. Anslyn

Protein kinases are therapeutic targets for many human diseases, but the lack of user-friendly quantitative assays limits the ability to follow the activities of numerous kinases at once (multiplexing). To develop such an assay, we report an array of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73613c42019a6513807a38b0bc4c312d
http://hdl.handle.net/11573/1624884

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