Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Tamer M.A. Mohamed"'
Autor:
Hong Gao, Saliha Pathan, Beverly R. E. A. Dixon, Aarthi Pugazenthi, Megumi Mathison, Tamer M.A. Mohamed, Todd K. Rosengart, Jianchang Yang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Cardiac cellular fate transition holds remarkable promise for the treatment of ischemic heart disease. We report that overexpressing two transcription factors, Sall4 and Gata4, which play distinct and overlapping roles in both pluripotent st
Externí odkaz:
https://doaj.org/article/dddb22f9f6054e26a9612826b2a513e0
Autor:
Cindy Y. Kok, Shinya Tsurusaki, Marti Cabanes-Creus, Sindhu Igoor, Renuka Rao, Rhys Skelton, Sophia H.Y. Liao, Samantha L. Ginn, Maddison Knight, Suzanne Scott, Mario Mietzsch, Rebecca Fitzsimmons, Jessica Miller, Tamer M.A. Mohamed, Robert McKenna, James J.H. Chong, Adam P. Hill, James E. Hudson, Ian E. Alexander, Leszek Lisowski, Eddy Kizana
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 459-473 (2023)
Recombinant adeno-associated viruses (rAAVs) have emerged as one of the most promising gene therapy vectors that have been successfully used in pre-clinical models of heart disease. However, this has not translated well to humans due to species diffe
Externí odkaz:
https://doaj.org/article/0a04499d5cb345478b523f2075186f26
Autor:
Ying Huang, Bin Wang, Faten Hassounah, S. Russ Price, Janet Klein, Tamer M.A. Mohamed, Yanhua Wang, Jeanie Park, Hui Cai, Xuemei Zhang, Xiaonan H. Wang
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 126-141 (2023)
Abstract Background Muscle wasting is a common complication of chronic kidney disease (CKD) that is associated with higher mortality. Although the mechanisms of myofibre loss in CKD has been widely studied, the contribution of muscle precursor cell (
Externí odkaz:
https://doaj.org/article/5327ce09ea9242c2af18493a95b47f85
Autor:
Andrea Ruiz-Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser hawimel o Alatawi, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Xiangjun Zhao, Oveena Fonseka, Xin Wang, Susanne S. Hille, Norbert Frey, Tao Wang, Tamer M.A. Mohamed, Oliver J. Müller, Elizabeth J. Cartwright, Wei Liu
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106970- (2023)
Summary: Despite the development of clinical treatments, heart failure remains the leading cause of mortality. We observed that p21-activated kinase 3 (PAK3) was augmented in failing human and mouse hearts. Furthermore, mice with cardiac-specific PAK
Externí odkaz:
https://doaj.org/article/0b1e474d4e224701832effe508afdc92
Autor:
Namrita Kaur, Sanskruti Ravindra Gare, Andrea Ruiz-Velasco, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Jiahan Shen, Handrean Soran, Tamer M.A. Mohamed, Wei Liu
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e14952- (2023)
Diabetes is a metabolic disorder with an increased risk of developing heart failure. Inflammation and damaged vasculature are the cardinal features of diabetes-induced cardiac damage. Moreover, systemic metabolic stress triggers discordant intercellu
Externí odkaz:
https://doaj.org/article/55b0f0bbe5e04d63af70d3b55ebd340c
Autor:
Namrita Kaur, Andrea Ruiz-Velasco, Rida Raja, Gareth Howell, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Kimberly Mace, Susanne S. Hille, Norbert Frey, Pablo Binder, Craig P. Smith, Helene Fachim, Handrean Soran, Eileithyia Swanton, Tamer M.A. Mohamed, Oliver J. Müller, Xin Wang, Jonathan Chernoff, Elizabeth J. Cartwright, Wei Liu
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103973- (2022)
Summary: Myocardial inflammation contributes to cardiomyopathy in diabetic patients through incompletely defined underlying mechanisms. In both human and time-course experimental samples, diabetic hearts exhibited abnormal ER, with a maladaptive shif
Externí odkaz:
https://doaj.org/article/60aa8df0966d4271a72fa6689cc50467
Autor:
Riham R.E. Abouleisa, Lindsey McNally, Abou bakr M. Salama, Sally K. Hammad, Qinghui Ou, Collin Wells, Pawel K. Lorkiewicz, Roberto Bolli, Tamer M.A. Mohamed, Bradford G. Hill
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102094- (2021)
Aims: The coordinated gene and metabolic programs that facilitate cardiomyocyte entry and progression in the cell cycle are poorly understood. The purpose of this study was to identify the metabolic changes that influence myocyte proliferation. Metho
Externí odkaz:
https://doaj.org/article/8a813a80fa3b441081af554c8527baeb
Autor:
Abigail Robertson, Tamer M.A. Mohamed, Zeinab El Maadawi, Nicholas Stafford, Thuy Bui, Dae-Sik Lim, Elizabeth J. Cartwright, Delvac Oceandy
Publikováno v:
Stem Cell Research, Vol 20, Iss C, Pp 42-49 (2017)
Adult fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSC) for use in various applications. However, there are challenges in iPSC generation including low reprogramming efficiency, yield, cell survival and viability. Since the H
Externí odkaz:
https://doaj.org/article/07172d931c7c4c2f9fd691c3488df205
Autor:
Ayman El-Baz, Fahmi Khalifa, Hisham Abdeltawab, K. Hammouda, Jessica M Miller, Qinghui Ou, Moustafa M Meki, Tamer M.A. Mohamed
Publikováno v:
Cardiovasc Eng Technol
PURPOSE—: Drug induced cardiac toxicity is a disruption of the functionality of cardiomyocytes which is highly correlated to the organization of the subcellular structures. We can analyze cellular structures by utilizing microscopy imaging data. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f392a5a3cdbbfc692e88dc926ed374b1
https://doi.org/10.1007/s13239-021-00571-6
https://doi.org/10.1007/s13239-021-00571-6
Autor:
Ying Huang, Bin Wang, Faten Hassounah, S. Russ Price, Janet Klein, Tamer M.A. Mohamed, Yanhua Wang, Jeanie Park, Hui Cai, Xuemei Zhang, Xiaonan H. Wang
Publikováno v:
Journal of cachexia, sarcopenia and muscleReferences.
Muscle wasting is a common complication of chronic kidney disease (CKD) that is associated with higher mortality. Although the mechanisms of myofibre loss in CKD has been widely studied, the contribution of muscle precursor cell (MPC) senescence rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269f1b4bd2bc0ded1ad3c9ed6d694b1d
https://pubmed.ncbi.nlm.nih.gov/36351875
https://pubmed.ncbi.nlm.nih.gov/36351875