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Akademický článek

Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles

Autor: Lukas Schartel, Cosimo Jann, Anna Wierczeiko, Tamer Butto, Stefan Mündnich, Virginie Marchand, Yuri Motorin, Mark Helm, Susanne Gerber, Edward A. Lemke

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Abstract RNA modifications play a pivotal role in the regulation of RNA chemistry within cells. Several technologies have been developed with the goal of using RNA modifications to regulate cellular biochemistry selectively, but achieving selective a

Externí odkaz: https://doaj.org/article/d9cbf5b31bc248f29aac4abbe01bbc0c

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Akademický článek

Nuclei on the Rise: When Nuclei-Based Methods Meet Next-Generation Sequencing

Autor: Tamer Butto, Kanak Mungikar, Peter Baumann, Jennifer Winter, Beat Lutz, Susanne Gerber

Publikováno v: Cells, Vol 12, Iss 7, p 1051 (2023)

In the last decade, we have witnessed an upsurge in nuclei-based studies, particularly coupled with next-generation sequencing. Such studies aim at understanding the molecular states that exist in heterogeneous cell populations by applying increasing

Externí odkaz: https://doaj.org/article/5821061fc8bc46149e1835248a269980

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Akademický článek

Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome

Autor: Alexis Cooper, Tamer Butto, Niklas Hammer, Somanath Jagannath, Desiree Lucia Fend-Guella, Junaid Akhtar, Konstantin Radyushkin, Florian Lesage, Jennifer Winter, Susanne Strand, Jochen Roeper, Ulrich Zechner, Susann Schweiger

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Birk-Barel intellectual disability is an imprinting syndrome due to maternally-only transmitted mutations of KCNK9/TASK3. Here authors are using a heterozygous deletion of the active maternal Kcnk9 allele to model the disease and show phenotypic resc

Externí odkaz: https://doaj.org/article/fea75db2dad1436d96f90d9e76ec3153

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NanopoReaTA: a user-friendly tool for nanopore-seq real-time transcriptional analysis

Autor: Anna Wierczeiko, Stefan Pastore, Stefan Mündnich, Mark Helm, Tamer Butto, Susanne Gerber

SummaryOxford Nanopore Technologies’ (ONT) sequencing platform offers an excellent opportunity to perform real-time analysis during sequencing. This feature allows for early insights into experimental data and accelerates a potential decision-makin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::620260124f53af2a03bb5eb79bdf9f63
https://doi.org/10.1101/2022.12.13.520220

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mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex

Autor: Tamer Butto, Martin Schüle, Jennifer Winter, Kristina Endres, Susanne Strand, Susanne Gerber, Sri Dewi, Laura Schlichtholz, Susann Schweiger

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 6034, p 6034 (2021)
International journal of molecular sciences, 22(11):6034

Dysregulated mammalian target of rapamycin (mTOR) activity is associated with various neurodevelopmental disorders ranging from idiopathic autism spectrum disorders to syndromes caused by single gene defects. This suggests that maintaining mTOR activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6579344764c8f6c1114f9435756c7c

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Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome

Autor: Susann Schweiger, Junaid Akhtar, Konstantin Radyushkin, Desiree Lucia Fend-Guella, Susanne Strand, Somanath Jagannath, Ulrich Zechner, Jennifer Winter, Florian Lesage, Jochen Roeper, Alexis Cooper, Niklas Hammer, Tamer Butto

Publikováno v: Nature Communications, 11(1):480
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.480. ⟨10.1038/s41467-019-13918-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, 2020, 11 (1), pp.480. ⟨10.1038/s41467-019-13918-4⟩

Mutations in the actively expressed, maternal allele of the imprinted KCNK9 gene cause Birk-Barel intellectual disability syndrome (BBIDS). Using a BBIDS mouse model, we identify here a partial rescue of the BBIDS-like behavioral and neuronal phenoty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cd76999641b15dc74479d7e8eb2849
https://repository.publisso.de/resource/frl:6422240

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