Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Tamer, Coskun"'
Autor:
Richard Aarnio, Anna Kirjavainen, Johan Rajander, Sarita Forsback, Kari Kalliokoski, Pirjo Nuutila, Zvonko Milicevic, Tamer Coskun, Axel Haupt, Iina Laitinen, Merja Haaparanta-Solin
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Background Fatty acid uptake can be measured using PET and 14-(R,S)‐[18F]fluoro‐6‐thia‐heptadecanoic acid ([18F]FTHA). However, the relatively rapid rate of [18F]FTHA metabolism significantly affects kinetic modeling of tissue uptake
Externí odkaz:
https://doaj.org/article/431ec5815c0a4c829a4b8d52c133bc9b
Autor:
Zhixiong Ying, Robin van Eenige, Xiaoke Ge, Christy van Marwijk, Joost M. Lambooij, Bruno Guigas, Martin Giera, Jan Freark de Boer, Tamer Coskun, Hongchang Qu, Yanan Wang, Mariëtte R. Boon, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104684- (2023)
Summary: Background: Combined glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP1R) agonism is superior to single GLP1R agonism with respect to glycemic control and weight loss in obese patients wit
Externí odkaz:
https://doaj.org/article/d8ae3b6711e4498db0d081190af4e7ce
Autor:
Ricardo J. Samms, GuoFang Zhang, Wentao He, Olga Ilkayeva, Brian A. Droz, Steven M. Bauer, Cynthia Stutsman, Valentina Pirro, Kyla A. Collins, Ellen C. Furber, Tamer Coskun, Kyle W. Sloop, Joseph T. Brozinick, Christopher B. Newgard
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101550- (2022)
Objectives: Tirzepatide, a dual GIP and GLP-1 receptor agonist, delivered superior glycemic control and weight loss compared to selective GLP-1 receptor (GLP-1R) agonism in patients with type 2 diabetes (T2D). These results have fueled mechanistic st
Externí odkaz:
https://doaj.org/article/6166df01a101493baa9fce8714c6b27b
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
A major challenge of obesity therapy is to sustain clinically relevant weight loss over time. Achieving this goal likely requires both reducing daily caloric intake and increasing caloric expenditure. Over the past decade, advances in pharmaceutical
Externí odkaz:
https://doaj.org/article/74c54035c1db4e8a9fdb2e24ec53373b
Autor:
Jo E. Lewis, Chloe Monnier, Hayley Marshall, Maxine Fowler, Rebecca Green, Scott Cooper, Aristeidis Chiotellis, Jeni Luckett, Alan C. Perkins, Tamer Coskun, Andrew C. Adams, Ricardo J. Samms, Francis J.P. Ebling, Kostas Tsintzas
Publikováno v:
Molecular Metabolism, Vol 31, Iss , Pp 45-54 (2020)
Objective: Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both lowered caloric intak
Externí odkaz:
https://doaj.org/article/a1e9dc6506f942278c9fc2ad5c935b3a
Autor:
Alessia Costa, Minrong Ai, Nicolas Nunn, Isabella Culotta, Jenna Hunter, Mehdi Boutagouga Boudjadja, Lourdes Valencia-Torres, Gabriella Aviello, David J. Hodson, Brandy M. Snider, Tamer Coskun, Paul J. Emmerson, Simon M. Luckman, Giuseppe D'Agostino
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101407- (2022)
Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. Methods: We employed
Externí odkaz:
https://doaj.org/article/1509df68416145fcabffe32f3d955be7
Autor:
Patrick J. Antonellis, Brian A. Droz, Richard Cosgrove, Libbey S. O'Farrell, Tamer Coskun, James W. Perfield, II, Steven Bauer, Mark Wade, Tara E. Chouinard, Joseph T. Brozinick, Andrew C. Adams, Ricardo J. Samms
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 131-139 (2019)
Objective: Fibroblast growth factor 19 (FGF19) is a postprandial hormone which plays diverse roles in the regulation of bile acid, glucose, and lipid metabolism. Administration of FGF19 to obese/diabetic mice lowers body weight, improves insulin sens
Externí odkaz:
https://doaj.org/article/f1ef67a9a6a44312b87faed6aa256893
Autor:
Hakan Ozben, Tamer Coskun
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background Giant cell tumor of the tendon sheath is the most common form of giant cell tumors and is the second most common soft tissue tumor of the hand region after ganglion cyst. Magnetic resonance imaging is the diagnostic tool of choice
Externí odkaz:
https://doaj.org/article/f9b23534aa5b4a2d9ac3ec2290e7678a
Autor:
Tamer Coskun, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister B. Bokvist, Xuewei Cui, Daniel A. Briere, Over Cabrera, William C. Roell, Uma Kuchibhotla, Julie S. Moyers, Charles T. Benson, Ruth E. Gimeno, David A. D'Alessio, Axel Haupt
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 3-14 (2018)
Objective: A novel dual GIP and GLP-1 receptor agonist, LY3298176, was developed to determine whether the metabolic action of GIP adds to the established clinical benefits of selective GLP-1 receptor agonists in type 2 diabetes mellitus (T2DM). Metho
Externí odkaz:
https://doaj.org/article/e80aeca8145a4ac5b361969b75b1dc5e
Autor:
Tim Heise, J. Hans DeVries, Shweta Urva, Jing Li, Edward J. Pratt, Melissa K. Thomas, Kieren J. Mather, Chrisanthi A. Karanikas, Julia Dunn, Axel Haupt, Zvonko Milicevic, Tamer Coskun
Publikováno v:
Diabetes Care. 46:998-1004
OBJECTIVE To evaluate the effects of tirzepatide on body composition, appetite, and energy intake to address the potential mechanisms involved in body weight loss with tirzepatide. RESEARCH DESIGN AND METHODS In a secondary analysis of a randomized,