Coupled Natural Fusion Enzymes in a Novel Biocatalytic Cascade Convert Fatty Acids to Amines

Autor: Shona M. Richardson, Piera M. Marchetti, Michael A. Herrera, Dominic J. Campopiano

Publikováno v: Richardson, S M, Marchetti, P M, Herrera, M A & Campopiano, D J 2022, ' Coupled Natural Fusion Enzymes in a Novel Biocatalytic Cascade Convert Fatty Acids to Amines ', ACS Catalysis, vol. 12, no. 20, pp. 12701-12710 . https://doi.org/10.1021/acscatal.2c02954

Tambjamine YP1 is a pyrrole-containing natural product. Analysis of the enzymes encoded in the Pseudoalteromonas tunicata "tam" biosynthetic gene cluster (BGC) identified a unique di-domain biocatalyst (PtTamH). Sequence and bioinformatic analysis pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3ee6763aeeb74291d22d6f29af4503
https://www.pure.ed.ac.uk/ws/files/327119654/20221005Campopianoacscatal.2c02954VoR.pdf

Characterization of Tambjamines Pigment from Marine Bacterium Pseudoalteromonas sp. PM2 Indigenous from Alor Island, Indonesia

Autor: Marcelinus A. S. Adhiwibawa, Matheus Randy Prabowo, Tatas H. P. Brotosudarmo, Edi Setiyono

Publikováno v: Indonesian Journal of Natural Pigments. 3:16-23

Pigments from marine bacteria have attracted the attention for scientists because of their extensive applications and currently exploration of new pigment sources from marine bacteria is still ongoing. Recently, we have successfully isolated six new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23339ebff0c69e65bc1f4bc34d303882
https://doi.org/10.33479/ijnp.2021.03.1.16-23

Purification and Kinetic Characterization of the Essential Condensation Enzymes Involved in Prodiginine and Tambjamine Biosynthesis

Autor: Victor Snieckus, Katherine J. Picott, Julie A. Deichert, Avena C. Ross, Ella Marie deKemp

Publikováno v: ChemBioChem. 21:1036-1042

Prodiginines and tambjamines are related families of bioactive alkaloid natural products with pharmaceutical potential. Both compound families result from a convergent biosynthetic pathway ending in the condensation of a conserved bipyrrole core with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21907e11c8bb6792020df8864cb99754
https://doi.org/10.1002/cbic.201900503

The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells

Autor: Jamile Magalhães Ferreira, Francisco Washington Araújo Barros-Nepomuceno, Bruno C. Cavalcanti, Fátima de Cássia Evangelista de Oliveira, Martin G. Banwell, Daniel Pascoalino Pinheiro, Xinghua Ma, Maria Goretti Rodrigues de Queiroz, Claudia Pessoa, Daniel de Araújo Viana

Publikováno v: ChemMedChem. 16(2)

The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5277e6b11432b3262c9b81d72d146d0e
https://pubmed.ncbi.nlm.nih.gov/32886437

The carbon chain-selective adenylation enzyme TamA: the missing link between fatty acid and pyrrole natural product biosynthesis

Autor: Mairi Ward, Joanna Simpson, Dominic J Campopiano, Van Kelly, Piera M. Marchetti

Publikováno v: Organic & Biomolecular Chemistry
Marchetti, P M, Ward, M, Campopiano, D J, Kelly, V & Simpson, J 2018, ' The carbon chain-selective adenylation enzyme TamA: the missing link between fatty acid and pyrrole natural product biosynthesis. ', Organic & Biomolecular chemistry . https://doi.org/10.1039/C8OB00441B

TamA is the adenylating enzyme that selects and activates fatty acids for tambjamine biosynthesis.
The marine bacterium Pseudoalteromonas tunicata produces the bipyrrole antibiotic tambjamine YP1. This natural product is built from common amino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1e482e3be67c918375f09d2c9c3120
https://doi.org/10.1039/c8ob00441b