Functional expression of the human glucose transporters GLUT2 and GLUT3 in yeast offers novel screening systems for GLUT-targeting drugs

Autor: Schmidl, Sina, Tamayo Rojas, Sebastian A., Iancu, Cristina V., Choe, Jun-Yong, Oreb, Mislav

Publikováno v: Frontiers in Molecular Biosciences

Human GLUT2 and GLUT3, members of the GLUT / SLC2 gene family, facilitate glucose transport in specific tissues. Their malfunction or misregulation is associated with serious diseases, including diabetes, metabolic syndrome, and cancer. Despite being

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Glucose-induced internalization of the S. cerevisiae galactose permease Gal2 is dependent on phosphorylation and ubiquitination of its aminoterminal cytoplasmic tail.

Autor: Tamayo Rojas, Sebastian A, Schmidl, Sina, Boles, Eckhard, Oreb, Mislav

Publikováno v: FEMS Yeast Research; 5/15/2021, Vol. 21 Issue 3, p1-10, 10p

Functional Expression of the Human Glucose Transporters GLUT2 and GLUT3 in Yeast Offers Novel Screening Systems for GLUT-Targeting Drugs.

Autor: Schmidl S; Institute of Molecular Biosciences, Faculty of Biological Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany., Tamayo Rojas SA; Institute of Molecular Biosciences, Faculty of Biological Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany., Iancu CV; Department of Chemistry, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, United States., Choe JY; Department of Chemistry, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, United States.; Department of Biochemistry and Molecular Biology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States., Oreb M; Institute of Molecular Biosciences, Faculty of Biological Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2021 Feb 18; Vol. 7, pp. 598419. Date of Electronic Publication: 2021 Feb 18 (Print Publication: 2020).