The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1

Autor: Bahareh Haddad Derafshi, Tamas Danko, Soham Chanda, Pedro J. Batista, Ulrike Litzenburger, Qian Yi Lee, Yi Han Ng, Anu Sebin, Howard Y. Chang, Thomas C. Südhof, Marius Wernig

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-28 (2022)

Abstract The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is a chromat

Externí odkaz: https://doaj.org/article/f6144c8eb12747dd9d2726213f094bb0

Direct induction of human neurons from fibroblasts carrying the neuropsychiatric 22q11.2 microdeletion reveals transcriptome- and epigenome-wide alterations

Autor: Alexis Mitelpunkt, Koji Tanabe, Anshul Kundaje, Wing Hung Wong, Cheen Euong Ang, Jonathan A. Bernstein, Tamas Danko, Soumya Kundu, Bruce J. Aronow, Joachim Hallmayer, Carolin Purmann, Alexander E. Urban, Shining Ma, Thomas C. Südhof, Yue Zhang, Marius Wernig

Standard methods for the creation of neuronal cells via direct induction from primary tissue use perinatal fibroblasts, which hinders the important study of patient specific genetic lesions such as those underlying neuropsychiatric disorders. To addr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ac794fc56f488fdc1f69e3270cabe91
https://doi.org/10.1101/2021.10.14.464344

Deuterium-depleted Water Stimulates GLUT4 Translocation in the Presence of Insulin, which Leads to Decreased Blood Glucose Concentration

Autor: Katalin Horvath, Beáta Zs. Kovács, Tamas Danko, Ildikó Somlyai, Gábor Somlyai, Miklos Z. Molnar

Publikováno v: Molecular and Cellular Biochemistry

BackgroundDeuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. In a phase II clinical study, deuterium depletion reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f26a7652a5e752919d55aebc0561251
https://doi.org/10.21203/rs.3.rs-117904/v1

Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4 Purinergic Receptors by two Complementary Methods

Autor: Matthias A. Hediger, Ákos Zsembery, Gergely Kovacs, Bernadett Balázs, Tamas Danko, László Köles

Publikováno v: Cellular Physiology and Biochemistry, Vol 32, Iss 1, Pp 11-24 (2013)
Balázs, B.; Dankó, T.; Kovács, G.; Köles, L.; Hediger, M. A.; Zsembery, Á. (2013). Investigation of the inhibitory effects of the benzodiazepine derivative, 5-BDBD on P2X4 purinergic receptors by two complementary methods. Cellular physiology and biochemistry, 32(1), pp. 11-24. Karger 10.1159/000350119

BACKGROUND/AIMS ATP-gated P2X4 purinergic receptors (P2X4Rs) are cation channels with important roles in diverse cell types. To date, lack of specific inhibitors has hampered investigations on P2X4Rs. Recently, the benzodiazepine derivative, 5-BDBD h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6965b585371b66ea39fe559dca566935
http://www.karger.com/Article/FullText/350119

Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB)

Autor: Tamas Danko, Nicolas Montalbetti, Ákos Zsembery, Matthias A. Hediger, Gergely Kovacs, Alexandre Simonin, Bernadett Balázs

Publikováno v: Cell Calcium. 52:468-480

TRPV6, a highly calcium-selective member of the transient receptor potential (TRP) channel superfamily, is a major pathway for calcium absorption in the fetal and adult body. It is expressed abundantly in the duodenum, the placenta and exocrine tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88351bff15980369cf3e765c29d35fc
https://doi.org/10.1016/j.ceca.2012.08.005