Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tamas, Yelland"'
Autor:
Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Álvaro Román-Fernández, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoino
Externí odkaz:
https://doaj.org/article/5313ed90f36c4817a2437ea2428b588c
Autor:
Yasmin ElMaghloob, Begoña Sot, Michael J McIlwraith, Esther Garcia, Tamas Yelland, Shehab Ismail
Publikováno v:
eLife, Vol 10 (2021)
The ADP-ribosylation factor-like 3 (ARL3) is a ciliopathy G-protein which regulates the ciliary trafficking of several lipid-modified proteins. ARL3 is activated by its guanine exchange factor (GEF) ARL13B via an unresolved mechanism. BART is describ
Externí odkaz:
https://doaj.org/article/872053f4f63a49b093bd0d5a9e817cad
VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins
Autor:
Charles Eldrid, Mire Zloh, Constantina Fotinou, Tamas Yelland, Lefan Yu, Filipa Mota, David L. Selwood, Snezana Djordjevic
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 372 (2022)
Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels’ formation and function. Each of the proteins from the homologous family VEGFA, VEGFB, VEGFC and VEGFD employs a core cysteine-knot structural domain
Externí odkaz:
https://doaj.org/article/60526d5f87e140dda472f99a45328337
Publikováno v:
Biochemistry
Two paralogs of the guanine dissociation inhibitor-like solubilizing factors UNC119, UNC119A and UNC119B, are present in the human genome. UNC119 binds to N-myristoylated proteins and masks the hydrophobic lipid from the hydrophilic cytosol, facilita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b27fd380a897553565f805dba8aa42
https://doi.org/10.1021/acs.biochem.1c00251
https://doi.org/10.1021/acs.biochem.1c00251
Autor:
Tamas Yelland, Esther Garcia, Charles Parry, Dominika Kowalczyk, Marta Wojnowska, Andrea Gohlke, Matja Zalar, Kenneth Cameron, Gillian Goodwin, Qing Yu, Peng-Cheng Zhu, Yasmin ElMaghloob, Angelo Pugliese, Lewis Archibald, Andrew Jamieson, Yong Xiang Chen, Duncan McArthur, Justin Bower, Shehab Ismail
RAS is a major anticancer drug target which requires membrane localization to activate downstream signal transduction. The direct inhibition of RAS has proven to be challenging. Here, we present a novel strategy for targeting RAS by stabilizing its i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d885e37325254d5946b7756fb441c13
https://eprints.gla.ac.uk/265430/1/265430.pdf
https://eprints.gla.ac.uk/265430/1/265430.pdf
Autor:
David L. Selwood, Paul Frankel, Tamas Yelland, Ian Zachary, Filipa Mota, Snezana Djordjevic, Constantina Fotinou, Andrew O’Leary, John Martin, Anastasia Patsiarika, Jennie A. Hutton, Jennifer Parker, A. W. Edith Chan
Publikováno v:
Chembiochem
Vascular endothelial growth factors (VEGFs) regulate significant pathways in angiogenesis, myocardial and neuronal protection, metabolism, and cancer progression. The VEGF‐B growth factor is involved in cell survival, anti‐apoptotic and antioxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a904c47925cd92312dd0c33cd9fc9799
https://doi.org/10.1002/cbic.202100463
https://doi.org/10.1002/cbic.202100463
Autor:
Tamas Yelland, Laura M. Machesky, Shehab Ismail, Savvas Nikolaou, Nikki R. Paul, Loic Fort, Anh Hoang Le
Publikováno v:
Journal of Cell Biology. 220
The Scar/WAVE complex drives actin nucleation during cell migration. Interestingly, the same complex is important in forming membrane ruffles during macropinocytosis, a process mediating nutrient uptake and membrane receptor trafficking. Mammalian CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0635b6aac4388e432539e1f8f72dca68
https://doi.org/10.1083/jcb.202012114
https://doi.org/10.1083/jcb.202012114
Autor:
Tamas Yelland, Jennifer P. Morton, Eva C Freckmann, Sara Zanivan, Lynn McGarry, Shehab Ismail, Hing Y. Leung, Konstantina Nikolatou, Laura C. A. Galbraith, Karen Blyth, Rachana Patel, David M. Bryant, Álvaro Román-Fernández, Marisa Nacke, Elke Markert, Sergio Lilla, Emma Shanks, Emma Sandilands, Susan M. Mason
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive cellular responses occur is unclear. Here, we report development of 3-Dimensional culture analyses to separately quantify growth and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6204b48306f528abf451c21e7b06e083
https://lirias.kuleuven.be/handle/123456789/678577
https://lirias.kuleuven.be/handle/123456789/678577
Autor:
Tamas Yelland, Loic Fort, Anh Hoang Le, Laura M. Machesky, Savvas Nikolaou, Shehab Ismail, Nikki R. Paul
The Scar/WAVE complex is the major driver of actin nucleation at the plasma membrane, resulting in lamellipodia and membrane ruffles. While lamellipodia aid migration, membrane ruffles can generate macropinosomes - cup-like structures - important for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::521d1161ead7a9c6e38c20358faf8800
https://doi.org/10.1101/2020.12.04.411645
https://doi.org/10.1101/2020.12.04.411645