Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease

Autor: Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R. Bennett, David Greenberg, David A. Bennett, Hermona Soreq

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) are involved in modulating cholinergic signaling, but their roles in Alzheimer’s and Parkinson’s diseases (AD and PD) remain unclear. We identified a higher frequency of the functiona

Externí odkaz: https://doaj.org/article/c2b9d62a14fa477fa1232ffcfb5df553

Cholinergic blockade of neuroinflammation: from tissue to RNA regulators

Autor: Tamara Zorbaz, Nimrod Madrer, Hermona Soreq

Publikováno v: Neuronal Signaling. 6

Inflammatory stimuli and consequent pro-inflammatory immune responses may facilitate neurodegeneration and threaten survival following pathogen infection or trauma, but potential controllers preventing these risks are incompletely understood. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09baf395fd3ad5a9460a408713c8e10a
https://doi.org/10.1042/ns20210035

Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents

Autor: Tamara Zorbaz, David Malinak, Tereza Hofmanova, Nikola Maraković, Suzana Žunec, Nikolina Maček Hrvat, Rudolf Andrys, Miroslav Psotka, Antonio Zandona, Jana Svobodova, Lukas Prchal, Sanja Fingler, Maja Katalinić, Zrinka Kovarik, Kamil Musilek

Publikováno v: European Journal of Medicinal Chemistry. 238:114377

The fluorinated bis-pyridinium oximes were designed and synthesized with the aim of increasing their nucleophilicity and potential to reactivate phosphorylated human recombinant acetylcholinesterase (AChE) and human purified plasmatic butyrylcholines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48e11bad698976b78e91b3a575a5fb2
https://doi.org/10.1016/j.ejmech.2022.114377

Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning

Autor: Zrinka Kovarik, Ludovic Jean, Suzana Žunec, Pierre-Yves Renard, Vesna Gabelica Marković, Tamara Zorbaz, Maja Katalinić, Vedran Micek, Nicolas Probst, Antonio Zandona, Anissa Braïki, Gordana Mendaš, Petra Mišetić, Nikolina Maček Hrvat

Publikováno v: ACS Chemical Neuroscience
ACS Chemical Neuroscience, American Chemical Society (ACS), 2020, 11 (7), pp.1072-1084. ⟨10.1021/acschemneuro.0c00032⟩

International audience; Nerve agents, the deadliest chemical warfare agents, are potent inhibitors of acetylcholinesterase (AChE) and cause rapid cholinergic crisis with serious symptoms of poisoning. Oxime reactivators of AChE are used in medical pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10eef766e1e0df319dd0aa7c39d06e2
https://doi.org/10.1021/acschemneuro.0c00032

Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes

Autor: Tamara Zorbaz, Kamil Kuca, Zrinka Kovarik, Kamil Musilek, David Malinak

Publikováno v: Chemico-biological interactions. 307

Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho- positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121c8021eab67232d9b195eca0c93710
https://pubmed.ncbi.nlm.nih.gov/31004594