Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tamara Tanos"'
Autor:
Javier Sanchez, Christina Claus, Christine McIntyre, Tamara Tanos, Axel Boehnke, Lena E. Friberg, Siv Jönsson, Nicolas Frances
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The majority of bispecific costimulatory antibodies in cancer immunotherapy are capable of exerting tumor-specific T-cell activation by simultaneously engaging both tumor-associated targets and costimulatory receptors expressed by T cells. The amount
Externí odkaz:
https://doaj.org/article/dfa2048939094ec19e21297c210bce9e
Autor:
Anton Kraxner, Franziska Braun, Wei-Yi Cheng, Tai-Hsien Ou Yang, Shweta Pipaliya, Marta Canamero, Emilia Andersson, Suzana Vega Harring, Sebastian Dziadek, Ann-Marie E. Bröske, Maurizio Ceppi, Tamara Tanos, Volker Teichgräber, Jehad Charo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThis study investigates the role of Fibroblast Activation Protein (FAP)-positive cancer-associated fibroblasts (FAP+CAF) in shaping the tumor immune microenvironment, focusing on its association with immune cell functionality and cytokine
Externí odkaz:
https://doaj.org/article/dd4ee8b221b142c392ddbfe6aedf0d7b
Autor:
Javier Sánchez, Christina Claus, Rosmarie Albrecht, Brenda C. Gaillard, Joana Marinho, Christine McIntyre, Tamara Tanos, Axel Boehnke, Lena E. Friberg, Siv Jönsson, Nicolas Frances
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 11, Pp 1804-1818 (2023)
Abstract FAP‐4‐1BBL is a bispecific antibody exerting 4‐1BB‐associated T‐cell activation only while simultaneously bound to the fibroblast activation protein (FAP) receptor, expressed on the surface of cancer‐associated fibroblasts. The t
Externí odkaz:
https://doaj.org/article/eca39fbc381d48aebd104930c6c16670
Autor:
Maurizio Ceppi, Bruno Gomes, Irina Klaman, Marta Canamero, Christian Heichinger, Tamara Tanos, Sabine Wilson, Mariana Bustamante, Chiahuey Ooi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/868e8b0a3c99497299b42e38438c364c
Autor:
Josep Tabernero, Maurizio Ceppi, Victor Moreno, Michael Hettich, Miguel Sanmamed, Christina Claus, Tatiana Hernandez, Iben Spanggaard, Analia Azaro, Maria Martinez Garcia, Alejo Rodriguez-Vida, Florian Heil, Oliver Krieter, Oliver Grimm, Marta Canamero, Jose Duarte, Alexandra-Cristina Nica, Iakov Davydov, Chia-Huey Ooi, Christian Heichinger, Ernesto Guarin, Radoiane Helbaj, Tamara Tanos, Eveline Nueesch, Irene Moreno
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/589c065d6b55460996eb1048ab2ddf88
Autor:
Tamara Tanos, Alberto Maria Saibene, Carlotta Pipolo, Paolo Battaglia, Giovanni Felisati, Alicia Rubio
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181151 (2017)
The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory functio
Externí odkaz:
https://doaj.org/article/1df9a4052fec40e499fdb3361de8f26b
Autor:
Ignacio Melero, Tamara Tanos, Mariana Bustamante, Miguel F. Sanmamed, Emiliano Calvo, Irene Moreno, Victor Moreno, Tatiana Hernandez, Maria Martinez Garcia, Alejo Rodriguez-Vida, Josep Tabernero, Analia Azaro, Mariano Ponz-Sarvisé, Iben Spanggaard, Kristoffer Rohrberg, Ernesto Guarin, Eveline Nüesch, Iakov I. Davydov, Chiahuey Ooi, José Duarte, Evelyne Chesne, Christine McIntyre, Maurizio Ceppi, Marta Cañamero, Oliver Krieter
Publikováno v:
Science Translational Medicine. 15
This first-in-human study evaluated RO7122290, a bispecific fusion protein carrying a split trimeric 4-1BB (CD137) ligand and a fibroblast activation protein α (FAP) binding site that costimulates T cells for improved tumor cell killing in FAP-expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c21d1128067bd586b01f93f4a042a37a
https://doi.org/10.1126/scitranslmed.abp9229
https://doi.org/10.1126/scitranslmed.abp9229
Autor:
Tamara Tanos, Kevin Smart, Valentina Gambardella, Kristoffer Rohrberg, Michael Ong, Maria Esperanza Rodriguez Ruiz, Jean-Pascal Machiels, Miguel Fernández Sanmamed, Josep Tabernero, Anna Spreafico, Daniel Renouf, Stephen Luen, Rachel Galot, Bernard Doger, Emiliano Calvo, Aung Naing, Samira Curdt, Nicolas Staedler, Mike Flores, Enrique Gómez Alcaide, Chiahuey Ooi, Michael Hettich, Sebastian Dziadek, Yuying Xie, Gabriel Schnetzler, Theresa Kolben, Linxinyu Xu, Vaios Karanikas, Christophe Boetsch
Publikováno v:
Cancer Research. 83:CT176-CT176
INTRODUCTION: Activated Tregs in the tumor micro-environment are correlated with poor outcomes, and are considered as key players in tumor immune-escape. So far, Treg depletion has not been successful in patients, either because adequate Treg depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217a7c59c9c441d0bb31a8fa513d8cd9
https://doi.org/10.1158/1538-7445.am2023-ct176
https://doi.org/10.1158/1538-7445.am2023-ct176
Autor:
Alejo Rodriguez-Vida, Analia Azaro, Michael Hettich, Radoiane Helbaj, Christian Heichinger, Ignacio Melero, Tamara Tanos, Ernesto Guarin, Tatiana Hernandez, Iben Spanggaard, Chia-Huey Ooi, Oliver Grimm, Florian Heil, Irene Moreno, Jose Duarte, Josep Tabernero, Marta Cañamero, Christina Claus, Maurizio Ceppi, Maria Martinez Garcia, Eveline Nueesch, Oliver Krieter, Miguel F. Sanmamed, Emiliano Calvo, Alexandra-Cristina Nica, Iakov I. Davydov, Kristoffer Staal Rohrberg, Victor Moreno
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background RO7122290 (RO) is a bispecific antibody-like fusion protein that simultaneously targets FAP, abundantly expressed by cancer-associated fibroblasts in most solid tumors, and 4-1BB, transiently expressed on activated T cells. Pre-clinical ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b239db7d0e4306ec7307270c2461ab41
https://doaj.org/article/589c065d6b55460996eb1048ab2ddf88
https://doaj.org/article/589c065d6b55460996eb1048ab2ddf88
Autor:
Tamara Tanos, Christian Heichinger, Sabine Wilson, Marta Canamero, Mariana Bustamante, Chiahuey Ooi, Irina Klaman, Bruno Gomes, Maurizio Ceppi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundWe previously described the capacity of RO7122290 (RO) - a FAP-targeted 4-1BB bispecific antibody - to induce CD8+ T cell infiltration and activation in the tumor (Moreno V. et al, SITC 2020). Aiming to compare pharmacodynamic (PD) changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037e1da6b9d3b5cdd0ca86ca4545c253
https://doi.org/10.1136/jitc-2021-sitc2021.527
https://doi.org/10.1136/jitc-2021-sitc2021.527