Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tamara Pfaff"'
Autor:
Alexander Birkmann, Susanne Bonsmann, Dirk Kropeit, Tamara Pfaff, Manickam Rangaraju, Melanie Sumner, Burkhard Timmler, Holger Zimmermann, Helmut Buschmann, Helga Ruebsamen-Schaeff
Publikováno v:
Journal of medicinal chemistry. 65(20)
When the nucleoside analogue acyclovir was introduced in the early 1980s, it presented a game-changing treatment modality for herpes simplex virus infections. Since then, work has been ongoing to improve the weaknesses that have now been identified:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69be1720a16217550c44fc70babd502
https://pubmed.ncbi.nlm.nih.gov/36202389
https://pubmed.ncbi.nlm.nih.gov/36202389
Autor:
Debra C. Quenelle, Thomas Goldner, Alexander Birkmann, Tamara Pfaff, Holger Zimmermann, Terri L. Rice, Mark N. Prichard, Deborah J. Collins, Susanne Bonsmann
Publikováno v:
Antiviral Research. 149:1-6
Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10120bfa283164eed57cc592845c456c
https://doi.org/10.1016/j.antiviral.2017.11.002
https://doi.org/10.1016/j.antiviral.2017.11.002
Autor:
Tamara Pfaff, Schwab Wilfried, Claudiu T. Supuran, Alexander Birkmann, Fabrizio Carta, Holger Zimmermann, Helmut Buschmann, Alfonso Maresca
A series of congeners structurally related to pritelivir, N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide, a helicase-primase inhibitor for the treatment of herpes simplex virus infections, was prepared. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7556a1211b03f00b2455159becadcb18
http://hdl.handle.net/2158/1141163
http://hdl.handle.net/2158/1141163
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:91-103
This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment-free period in control and 30, 60, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f12530ae8e956c1264ec3a0477050d76
https://doi.org/10.1002/bdrb.21046
https://doi.org/10.1002/bdrb.21046
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 98(1)
This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment-free period in control and 30, 60, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e62da0359a932a0c4d924e7f0159c198
https://pubmed.ncbi.nlm.nih.gov/23349029
https://pubmed.ncbi.nlm.nih.gov/23349029
Autor:
Adriaan A. van Bodegraven, Yvette E. Lentferink, Nanne K. H. de Boer, Tim G. J. de Meij, Marc P. van der Schee, Tamara Pfaff
Publikováno v:
Gastroenterology. 144:S-443
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b49b4e9bc59f87c47e418eb09ffb1d8c
https://doi.org/10.1016/s0016-5085(13)61635-2
https://doi.org/10.1016/s0016-5085(13)61635-2