Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tamara Nyberg"'
Autor:
Tamara Nyberg, Lea Guo, Brian Agnew, Courtenay Hart, Loren G. Fong, Lai N. Chan, Brandon S.J. Davies, Fuyuhiko Tamanoi, Stephen G. Young
Publikováno v:
ELECTROPHORESIS. 30:3598-3606
A recently developed proteomic strategy, the "GG-azide"-labeling approach, is described for the detection and proteomic analysis of geranylgeranylated proteins. This approach involves metabolic incorporation of a synthetic azido-geranylgeranyl analog
Autor:
Bernhard Kuster, Tamara Nyberg, Nadine Sobotzki, Hannes Hahne, Vladimir S. Borodkin, Brian Agnew, Daan M. F. van Aalten, Dominic Helm
Publikováno v:
Journal of proteome research. 12(2)
The post-translational modification of proteins with N-acetylglucosamine (O-GlcNAc) is involved in the regulation of a wide variety of cellular processes and associated with a number of chronic diseases. Despite its emerging biological significance,
Publikováno v:
SPIE Proceedings.
Described herein is an application of the copper(I)-catalyzed Huisgen [3+2] cycloaddition between azides and alkynes, or click chemistry, for the universal two-step detection of biological macromolecules. The first step involves the metabolic incorpo