Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Tamara Monesmith"'
1
Robust Pre-Clinical Results and Large-Scale Manufacturing Process for Edit-301: An Autologous Cell Therapy for the Potential Treatment of SCD
Autor: Jack Heath, David K. Wood, Harry An, Charles F Albright, Kate Zhang, Edouard De Dreuzy, Sandra Teixeira, Kai-Hsin Chang, Tamara Monesmith, Patricia Sousa, Tusneem Janoudi, Scott Hansen
Publikováno v: Blood. 136:45-46
Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 100,000 individuals in the United States. As fetal hemoglobin (HbF) has been shown to be protective against clinical manifestation of SCD, we are developing EDIT-301, an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f31da9e1c7ad78b878b9a9246ede0847
https://doi.org/10.1182/blood-2020-140073
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2
Dendritic cells for active immunotherapy: Optimizing design and manufacture in order to develop commercially and clinically viable products
Autor: Theresa L. Whiteside, Irina Y. Tcherepanova, Charles A. Nicolette, Donald Healey, Tamara Monesmith, L. H. Finke, F. Miesowicz, P. Whelton, L. Coombs
Publikováno v: Vaccine. 25:B47-B60
Dendritic cell (DC) active immunotherapy is potentially efficacious in a broad array of malignant disease settings. However, challenges remain in optimizing DC-based therapy for maximum clinical efficacy within manufacturing processes that permit qua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b3bf5e885f27085a42a9e1c1d576f3
https://doi.org/10.1016/j.vaccine.2007.06.006
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3
An improved RNA amplification procedure results in increased yield of autologous RNA transfected dendritic cell-based vaccine
Autor: Marcus S. Norris, Jonathan H. Freedman, Tamara Monesmith, Jason Harris, Irina Y. Tcherepanova, Alicia Ubben
Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1724:127-136
Use of antigen encoding RNA transfected Dendritic cells in the field of cancer immunotherapy has been well established. The use of RNA overcomes limitations inherent to other autologous DC-based vaccines as it does not require specific HLA haplotypes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ba4a6802d7ecfe0fb7ccfd624c9392
https://doi.org/10.1016/j.bbagen.2005.03.013
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5
Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
Autor: Kavita M. Dhodapkar, Ranjini K. Sundaram, Natalia Neparidze, Fred Miesowicz, Madhav V. Dhodapkar, Shiny Nair, Tamara Monesmith, Lin Zhang, Joshua Richter
Natural killer T (iNKT) cells can help mediate immune surveillance against tumors in mice. Prior studies targeting human iNKT cells were limited to therapy of advanced cancer and led to only modest activation of innate immunity. Clinical myeloma is p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3783d6002430e43ca10f583893d787
https://europepmc.org/articles/PMC3548165/
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6
Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy
Autor: Mohamed Rachid Boulassel, Oleg Yegorov, Irina Y. Tcherepanova, Rafick Pierre Sekaly, Tamara Monesmith, Don Healey, Claire Landry, Charles A. Nicolette, Bader Yassine-Diab, Renu Jain, L. H. Finke, Jean-Pierre Routy
Publikováno v: Clinical immunology (Orlando, Fla.). 134(2)
Immunogenicity, manufacturing feasibility, and safety of a novel, autologous dendritic cell (DC)-based immunotherapy (AGS-004) was evaluated in ten human immunodeficiency virus type 1 (HIV-1)-infected adults successfully treated with antiretroviral t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2feb58baae9cbf8383c2c52cf513c4
https://pubmed.ncbi.nlm.nih.gov/19889582
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