Antimicrobial Peptides in 2014

Autor: Guangshun Wang, Biswajit Mishra, Kyle Lau, Tamara Lushnikova, Radha Golla, Xiuqing Wang

Publikováno v: Pharmaceuticals, Vol 8, Iss 1, Pp 123-150 (2015)

This article highlights new members, novel mechanisms of action, new functions, and interesting applications of antimicrobial peptides reported in 2014. As of December 2014, over 100 new peptides were registered into the Antimicrobial Peptide Databas

Externí odkaz: https://doaj.org/article/07644640a14f42b7b4d772f5fa366b83

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

Autor: Xiuqing Wang, Guangshun Wang, Tamara Lushnikova, Jayaram Lakshmaiah Narayana, Biswajit Mishra

Publikováno v: Proceedings of the National Academy of Sciences. 116:13517-13522

As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how AMPs are designed with in vivo efficacy is poorly understood. Our study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01887c4cfc088f7db825a69321f8485
https://doi.org/10.1073/pnas.1821410116

Two distinct amphipathic peptide antibiotics with systemic efficacy

Autor: Santhi Gorantla, Tamara Lushnikova, Daryl J. Murry, Xiangli Dang, Evgeniy S. Salnikov, D. Zarena, Qianhui Wu, Yingxia Zhang, Biswajit Mishra, Jayaram Lakshmaiah Narayana, Burkhard Bechinger, Guangshun Wang, Kirk W. Foster, Yashpal S. Chhonker, Fangyu Wang, Caitlin N. Murphy

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (32), pp.19446-19454. ⟨10.1073/pnas.2005540117⟩
Proc Natl Acad Sci U S A

Antimicrobial peptides are important candidates for developing new classes of antibiotics because of their potency against antibiotic-resistant pathogens. Current research focuses on topical applications and it is unclear how to design peptides with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83307cf5045e8eaec62e07eb682a4dc
https://hal.archives-ouvertes.fr/hal-03011069/document

The π Configuration of the WWW Motif of a Short Trp-Rich Peptide Is Critical for Targeting Bacterial Membranes, Disrupting Preformed Biofilms, and Killing Methicillin-Resistant Staphylococcus aureus

Autor: Biswajit Mishra, D. Zarena, Guangshun Wang, Fangyu Wang, Tamara Lushnikova

Publikováno v: Biochemistry. 56:4039-4043

Tryptophan-rich peptides, being short and suitable for large-scale chemical synthesis, are attractive candidates for developing a new generation of antimicrobials to combat antibiotic-resistant bacteria (superbugs). Although there are numerous pictur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d2eefc280e3c293b315b1657deca0a
https://doi.org/10.1021/acs.biochem.7b00456

Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37

Autor: Guangshun, Wang, Jayaram Lakshmaiah, Narayana, Biswajit, Mishra, Yingxia, Zhang, Fangyu, Wang, Chunfeng, Wang, D, Zarena, Tamara, Lushnikova, Xiuqing, Wang

Publikováno v: Advances in experimental medicine and biology. 1117

The incorporation of the innate immune system into humans is essential for survival and health due to the rapid replication of invading microbes and the delayed action of the adaptive immune system. Antimicrobial peptides are important components of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f1742fd1982b7f046e30e5e78c4716a
https://pubmed.ncbi.nlm.nih.gov/30980360