Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Tamara L. Doering"'
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Cryptococcus neoformans is an environmentally acquired fungal pathogen that causes over 140,000 deaths per year. Cryptococcal infection occurs when infectious particles are deposited into the lung, where they encounter host phagocytic cells.
Externí odkaz:
https://doaj.org/article/5dff9894c62a4b92b7a622e17b4e46f1
Autor:
Camila Diehl, Camila Figueiredo Pinzan, Patrícia Alves de Castro, Endrews Delbaje, Laura C. García Carnero, Eddy Sánchez-León, Kabir Bhalla, James W. Kronstad, Dong-gyu Kim, Tamara L. Doering, Sondus Alkhazraji, Nagendra N. Mishra, Ashraf S. Ibrahim, Mami Yoshimura, Luis Alberto Vega Isuhuaylas, Lien Thi Kim Pham, Yoko Yashiroda, Charles Boone, Thaila Fernanda dos Reis, Gustavo H. Goldman
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Cryptococcus neoformans causes cryptococcosis, one of the most prevalent fungal diseases, generally characterized by meningitis. There is a limited and not very effective number of drugs available to combat this disease. In this manuscript,
Externí odkaz:
https://doaj.org/article/e7e096fb2e1e45db88ee688644d28cb3
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Ergosterol, the major sterol in fungal membranes, is critical for defining membrane fluidity and regulating cellular processes. Although ergosterol synthesis has been well defined in model yeast, little is known about sterol organization in
Externí odkaz:
https://doaj.org/article/15ce59d610be448b9674d17b3f1ca4f8
Autor:
Daphne Boodwa-Ko, Tamara L. Doering
Publikováno v:
Journal of Fungi, Vol 10, Iss 2, p 114 (2024)
Cryptococcus neoformans is an opportunistic fungal pathogen that can cause severe meningoencephalitis in immunocompromised hosts and is a leading cause of death in HIV/AIDS patients. This pathogenic yeast is surrounded by a polysaccharide capsule tha
Externí odkaz:
https://doaj.org/article/1ae9d20df8d849b7b11c91f3edaf74a7
Autor:
Felipe H. Santiago-Tirado, Thomas Hurtaux, Jennifer Geddes-McAlister, Duy Nguyen, Volkhard Helms, Tamara L. Doering, Karin Römisch
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The fungal pathogen Cryptococcus neoformans is distinguished by a cell-wall-anchored polysaccharide capsule that is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway. Protein secretion begins wi
Externí odkaz:
https://doaj.org/article/7a705d2e57474a73a7dffbac8608fa80
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The authors show that resistance to the antifungal 5-fluorocytosine in Cryptococcus deuterogattii is acquired more frequently in isolates with elevated mutation rate, and is associated with alterations in capsule biosynthesis and nucleotide metabolis
Externí odkaz:
https://doaj.org/article/f7fc4a07b3e44f9382953de7b6a59040
Publikováno v:
Microbial Cell, Vol 8, Iss 5, Pp 108-110 (2021)
The regulation of virulence factor production and deployment is crucial for the establishment of microbial infection and subsequent pathogenesis. If these processes are not properly coordinated, the infecting pathogen is less likely to both survive t
Externí odkaz:
https://doaj.org/article/9465a08cfcec4863bb0a741914e9adb6
Autor:
Tanya R. McKitrick, Margaret E. Ackerman, Robert M. Anthony, Clay S. Bennett, Michael Demetriou, Gregory A. Hudalla, Katharina Ribbeck, Stefan Ruhl, Christina M. Woo, Loretta Yang, Seth J. Zost, Ronald L. Schnaar, Tamara L. Doering
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune responses and glyc
Externí odkaz:
https://doaj.org/article/3000e7b4d667473fbab845be76c82ed3
Autor:
Julia C. V. Reuwsaat, Daniel P. Agustinho, Heryk Motta, Andrew L. Chang, Holly Brown, Michael R. Brent, Livia Kmetzsch, Tamara L. Doering
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
The pathogenic yeast Cryptococcus neoformansC. neoformans
Externí odkaz:
https://doaj.org/article/367b274cf5dc40069dd0cd830bbb946a
Autor:
Ryan Z. Friedman, Stacey R. Gish, Holly Brown, Lindsey Brier, Nicole Howard, Tamara L. Doering, Michael R. Brent
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 3, Pp 815-822 (2018)
Received wisdom in the field of fungal biology holds that the process of editing a genome by transformation and homologous recombination is inherently mutagenic. However, that belief is based on circumstantial evidence. We provide the first direct me
Externí odkaz:
https://doaj.org/article/7d068d646ee04403ba4cbfca5f838b36