Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tamara J Nicolson"'
Autor:
Jean François Gautier, Tarvinder K. Taneja, Philippe Froguel, Guy A. Rutter, Andrei I. Tarasov, Martine Vaxillaire, Jocelyn M. Baldwin, Guillaume Charpentier, Stephen A. Baldwin, Jean-Pierre Riveline, Tamara J. Nicolson
Publikováno v:
Diabetes. 57:1595-1604
OBJECTIVE— ATP-sensitive K+ channels (KATP channels) link glucose metabolism to the electrical activity of the pancreatic β-cell to regulate insulin secretion. Mutations in either the Kir6.2 or sulfonylurea receptor (SUR) 1 subunit of the channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97763d4083f2800921f01c76c4ced2d2
https://doi.org/10.2337/db07-1547
https://doi.org/10.2337/db07-1547
Publikováno v:
Journal of Drug Metabolism & Toxicology.
Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::701798b320f482d9a2fdcaa7d0ac40bd
https://doi.org/10.4172/2157-7609.1000101
https://doi.org/10.4172/2157-7609.1000101
Publikováno v:
Journal of Drug Metabolism & Toxicology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a551b7644c0afc85416c1f0e653116
https://doi.org/10.4172/2157-7609.1000103
https://doi.org/10.4172/2157-7609.1000103
Publikováno v:
Trends in pharmacological sciences. 31(3)
Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised therapies and the need to prevent drug attrition there is a compelling n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5f4fb691101372e7c8dfb7ce157f85
https://pubmed.ncbi.nlm.nih.gov/20117848
https://pubmed.ncbi.nlm.nih.gov/20117848
Autor:
Guy A. Rutter, Maarten Merkx, Elisa A. Bellomo, Melissa S. T. Koay, Jan L. Vinkenborg, Tamara J. Nicolson
Publikováno v:
Nature Methods, 6(10), 737-740. Nature Publishing Group
We developed genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon Zn(2+) binding, have affinities that span the pico- to nanomolar range and can readily be targeted to subcellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600cc3928bc1298cd6ae0435ff45f593
http://hdl.handle.net/10044/1/22107
http://hdl.handle.net/10044/1/22107
Autor:
Fiona M. Gribble, Andrei I. Tarasov, Merewyn K. Loder, Tarvinder K. Taneja, Helen E. Parker, Nadeeja Wijesekara, Jocelyn M. Baldwin, Myriam Masseboeuf, Raphael Scharfmann, Philippe Froguel, Katrin Kronenberger, Gabriela da Silva Xavier, Volodymir Stetsyuk, Vasilij Koshkin, Frank Reimann, Paul Johnson, Guy A. Rutter, Peter Arvan, Armen V. Gyulkhandanyan, Robert Sladek, Stephen J. Hughes, Sarah Libert, Rémy Burcelin, Ming Liu, Tamara J. Nicolson, Elisa A. Bellomo, Fabrice Chimienti, Philippe Ravassard, Raffaella Carzaniga, Frans Schuit, Stephen A. Baldwin, Michael B. Wheeler, Roberto Lara-Lemus
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2009, 58 (9), pp.2070-2083. ⟨10.2337/db09-0551⟩
Diabetes, American Diabetes Association, 2009, 58 (9), pp.2070-2083. 〈10.2337/db09-0551〉
Diabetes, 2009, 58 (9), pp.2070-2083. ⟨10.2337/db09-0551⟩
Diabetes, American Diabetes Association, 2009, 58 (9), pp.2070-2083. ⟨10.2337/db09-0551⟩
Diabetes, American Diabetes Association, 2009, 58 (9), pp.2070-2083. 〈10.2337/db09-0551〉
Diabetes, 2009, 58 (9), pp.2070-2083. ⟨10.2337/db09-0551⟩
OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdbdf4d3b3ba7b4ef8557d7e5f02747
https://www.hal.inserm.fr/inserm-00410150
https://www.hal.inserm.fr/inserm-00410150
Autor:
George Hammons, Beverly D. Lyn-Cook, Tamara J Nicolson, Stancy Joseph, Beverly Word, Honggang Wang
Publikováno v:
Cancer Research. 74:770-770
Differences in pharmacokinetics and drug metabolism present a major challenge in treatment of diseases, such as cancer, as they contribute to variations that characterizes how well drugs respond. Variation in the expression of major drug metabolizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::396e54bed339bfad41ae7cf87101cd57
https://doi.org/10.1158/1538-7445.am2014-770
https://doi.org/10.1158/1538-7445.am2014-770
Autor:
Tamara J Nicolson, Ruth A. Roberts
Publikováno v:
Toxicology. 278:343
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d28c42d81e8bceaf8ebe759f8ce96708
https://doi.org/10.1016/j.tox.2010.08.085
https://doi.org/10.1016/j.tox.2010.08.085
Autor:
Guy A. Rutter, Philippe Froguel, J.F. Gautier, Guillaume Charpentier, Andrei I. Tarasov, Sylvia Franc, Tamara J. Nicolson, Martine Vaxillaire, J.P. Riveline, L.S. Fetita
Publikováno v:
Diabetes & Metabolism. 34:H88
Introduction Des mutations activatrices des 2 sous-unites du canal KATP de la cellule b sont associees au diabete neonatal. Nous decrivons ici une mutation du gene ABCC8 codant pour SUR1 associee au diabete de type 2. Materiels et methodes Le gene AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927cf6e33514b50dde7489a48cc8610c
https://doi.org/10.1016/s1262-3636(08)73084-2
https://doi.org/10.1016/s1262-3636(08)73084-2
Autor:
Bridgett Green-Knox, Beverly Lyn-Cook, Tamara J Nicolson, Stancy Joseph, George Hammons, Beverly Word
Publikováno v:
Biology of Sex Differences
Background Differences in expression of drug transporters in human kidney contribute to changes in pharmacokinetics and toxicokinetics of a variety of drug compounds. The basal expression levels of genes involved in drug transport processes in the ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c9c0f75f3d777a86b9e8921ed8f928