Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tamara I. King"'
Autor:
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita
Publikováno v:
J Pharmacol Exp Ther
Mitragynine, an opioidergic alkaloid present in Mitragyna speciosa (kratom), is metabolized by cytochrome P450 3A (CYP3A) to 7-hydroxymitragynine, a more potent opioid receptor agonist. The extent to which conversion to 7-hydroxymitragynine mediates
Autor:
Shyam H. Kamble, Erin C. Berthold, Siva Rama Raju Kanumuri, Tamara I. King, Michelle A. Kuntz, Francisco León, Marco Mottinelli, Lance R. McMahon, Christopher R. McCurdy, Abhisheak Sharma
Publikováno v:
The AAPS Journal. 24
Autor:
Shyam H, Kamble, Erin C, Berthold, Siva Rama Raju, Kanumuri, Tamara I, King, Michelle A, Kuntz, Francisco, León, Marco, Mottinelli, Lance R, McMahon, Christopher R, McCurdy, Abhisheak, Sharma
Publikováno v:
The AAPS journal. 24(5)
Speciociliatine, a diastereomer of mitragynine, is an indole-based alkaloid found in kratom (Mitragyna speciosa). Kratom has been widely used for the mitigation of pain and opioid dependence, as a mood enhancer, and/or as an energy booster. Speciocil
Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy
Autor:
Abhisheak Sharma, Christopher R. McCurdy, Carolina Lopera-Londoño, Tamara I. King, Bonnie A. Avery, Shyam H. Kamble, Lance R. McMahon, Francisco León, Aidan J. Hampson, Kanumuri Siva Rama Raju, Erin C. Berthold
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Kratom is widely consumed in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid receptor agonist. 7-Hydroxymitragynine (7-HMG) is a mit
Autor:
Kanumuri Siva Rama Raju, Erin C. Berthold, Elizabeth A. Maxwell, Francisco León, Abhisheak Sharma, Christopher R. McCurdy, Bonnie A. Avery, Tamara I. King, Lance R. McMahon, Shyam H. Kamble
Publikováno v:
Planta Med
Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is often
Autor:
Tamara I, King, Amruta, Indapurkar, Isra, Tariq, Ryan, DePalma, Sabyasachy, Mistry, Claudia, Alvarez-Baron, Omnia A, Ismaiel, Wendy, Wu, Kimberly, Chiu, Vikram, Patel, Rodney, Rouse, David G, Strauss, Murali K, Matta
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 118:107229
ICH S7B recommends screening for hERG channel block using patch clamp recordings to assess a drug's proarrhythmic risk. Block of the hERG channel has been associated with clinical QT
Autor:
Luis F. Restrepo, Erin C. Berthold, Aidan J. Hampson, Avi Patel, Lance R. McMahon, Carolina Lopera-Londoño, Takato Hiranita, Shyam H. Kamble, Samuel Obeng, Abhisheak Sharma, Lea R. Gamez-Jimenez, Francisco León, Clinton E. Canal, Marco Mottinelli, Christopher R. McCurdy, Yiming Chen, Tamara I. King
Publikováno v:
J Med Chem
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b326c3ebef7e4aed6ae82cdd6614a
https://europepmc.org/articles/PMC9235362/
https://europepmc.org/articles/PMC9235362/
Autor:
Francisco León, Tamara I. King, Christopher R. McCurdy, Nelson Jeng Yeou Chear, Bonnie A. Avery, Surash Ramanathan, Abhisheak Sharma, Shyam H. Kamble, Erin C. Berthold
Publikováno v:
Drug Test Anal
Kratom (Mitragyna speciosa) is a psychoactive plant popular in the United States for the self-treatment of pain and opioid addiction. For standardization and quality control of raw and commercial kratom products, an ultra-performance liquid chromatog
Autor:
Raluca Popa, Shyam H. Kamble, Raju S. Kanumuri, Tamara I. King, Erin C. Berthold, Sebastiano Intagliata, Abhisheak Sharma, Christopher R. McCurdy
Publikováno v:
J Chromatogr B Analyt Technol Biomed Life Sci
Sigma-1 receptors are involved in pain modulation, particularly in cases of nerve injury and neuropathic pain. High-affinity ligands with improved pharmacokinetic profiles are needed to further investigate the properties of these receptors and their
Autor:
Abhisheak Sharma, Elizabeth A. Maxwell, Aidan J. Hampson, Francisco León, Kanumuri Siva Rama Raju, Lance R. McMahon, Tamara I. King, Shyam H. Kamble, Erin C. Berthold, Christopher R. McCurdy
Publikováno v:
Eur J Drug Metab Pharmacokinet
BACKGROUND AND OBJECTIVES: 7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial μ-opioid receptor (MOR