Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tamara Heintze"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract HepaRG cells are increasingly accepted as model for human drug metabolism and other hepatic functions. We used lentiviral transduction of undifferentiated HepaRG cells to deliver Cas9 and two alternative sgRNAs targeted at NADPH:cytochrome P
Externí odkaz:
https://doaj.org/article/da470472d166433891d6594b177bafae
Autor:
Tamara Heintze, Denise Wilhelm, Thierry Schmidlin, Ute Hofmann, Ulrich M. Zanger, Matthias Schwab, Kathrin Klein
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other steroids as well as in the oxidative metabolism of
Externí odkaz:
https://doaj.org/article/34b2326905204693ab01efe6622b88fe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
HepaRG cells are increasingly accepted as model for human drug metabolism and other hepatic functions. We used lentiviral transduction of undifferentiated HepaRG cells to deliver Cas9 and two alternative sgRNAs targeted at NADPH:cytochrome P450 oxido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38b05a44e8ca257c2b82fa048ea516e
https://doi.org/10.1038/s41598-020-79952-1
https://doi.org/10.1038/s41598-020-79952-1